pI: 4.4971 |
Length (AA): 214 |
MW (Da): 23665 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 211 | 1eq6 (A) | 32 | 218 | 28.00 | 0 | 1 | 1.06 | -0.72 |
14 | 210 | 1eq6 (A) | 36 | 217 | 32.00 | 0.000000012 | 1 | 1.13 | -0.59 |
12 | 210 | 1eq6 (A) | 34 | 217 | 30.00 | 0 | 1 | 1.14861 | -0.5 |
14 | 210 | 1eq6 (A) | 36 | 217 | 32.00 | 0.000000026 | 1 | 1.11846 | -0.5 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_129574)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G69680 | Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein |
Candida albicans | CaO19.3446 | similar to S. cerevisiae MOG1 (YJR074W) guanine nucleotide release factor for Ran GTPase |
Candida albicans | CaO19.10950 | similar to S. cerevisiae MOG1 (YJR074W) guanine nucleotide release factor for Ran GTPase |
Cryptosporidium hominis | Chro.10223 | HSPC236 |
Cryptosporidium parvum | cgd1_1940 | possible RAN guanine nucleotide release factor |
Dictyostelium discoideum | DDB_G0285871 | Mog1 family protein |
Echinococcus granulosus | EgrG_000849800 | ran guanine nucleotide release factor |
Echinococcus multilocularis | EmuJ_000849800 | ran guanine nucleotide release factor |
Homo sapiens | ENSG00000108961 | RAN guanine nucleotide release factor |
Leishmania braziliensis | LbrM.23.1520 | Ran-binding protein, putative |
Leishmania donovani | LdBPK_231660.1 | Ran-binding protein, putative |
Leishmania infantum | LinJ.23.1660 | Ran-binding protein, putative |
Leishmania major | LmjF.23.1400 | Ran-binding protein, putative |
Leishmania mexicana | LmxM.23.1400 | Ran-binding protein, putative |
Mus musculus | ENSMUSG00000032892 | RAN guanine nucleotide release factor |
Neospora caninum | NCLIV_005440 | mog1 protein, putative |
Oryza sativa | 4336045 | Os04g0459600 |
Plasmodium berghei | PBANKA_1359100 | nuclear import protein MOG1, putative |
Plasmodium falciparum | PF3D7_1346200 | nuclear import protein MOG1, putative |
Plasmodium knowlesi | PKNH_1255100 | nuclear import protein MOG1, putative |
Plasmodium vivax | PVX_083210 | nuclear import protein MOG1, putative |
Plasmodium yoelii | PY02511 | Homo sapiens HSPC236, putative |
Saccharomyces cerevisiae | YJR074W | Mog1p |
Schistosoma japonicum | Sjp_0307600 | Ran guanine nucleotide release factor, putative |
Schistosoma mansoni | Smp_048930 | ran-binding protein |
Schmidtea mediterranea | mk4.012938.00 | Ran guanine nucleotide release factor |
Schmidtea mediterranea | mk4.001713.06 | Ran guanine nucleotide release factor |
Trypanosoma brucei gambiense | Tbg972.8.3130 | RNA-binding protein, putative |
Trypanosoma brucei | Tb927.8.3370 | Ran-binding protein, putative |
Trypanosoma cruzi | TcCLB.509769.63 | Ran-binding protein, putative |
Toxoplasma gondii | TGME49_222040 | Ran-interacting Mog1 protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3370 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3370 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3370 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3370 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1359100 | Plasmodium berghei | Essential | plasmo |
TGME49_222040 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.