pI: 6.4584 |
Length (AA): 154 |
MW (Da): 17808 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 154 | 4tql (A) | 49 | 195 | 12.00 | 0.0000066 | 0.18 | 1.07763 | -0.5 |
6 | 124 | 3zhe (C) | 210 | 366 | 31.00 | 0.6 | 0.32 | 0.790127 | -0.05 |
14 | 154 | 4uos (A) | 3 | 136 | 10.00 | 0.17 | 0.14 | 1.01258 | -1.02 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite, Female Gametocyte, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_129950)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G31725 | hypothetical protein |
Arabidopsis thaliana | AT2G43720 | hypothetical protein |
Arabidopsis thaliana | AT1G05730 | hypothetical protein |
Babesia bovis | BBOV_II006450 | YOU2-like small euk. C2C2 zinc finger protein |
Brugia malayi | Bm1_30190 | RIKEN cDNA 2010309E21 |
Caenorhabditis elegans | CELE_ZK637.2 | Protein ZK637.2 |
Drosophila melanogaster | Dmel_CG12661 | CG12661 gene product from transcript CG12661-RB |
Drosophila melanogaster | Dmel_CG5323 | CG5323 gene product from transcript CG5323-RA |
Drosophila melanogaster | Dmel_CG5327 | CG5327 gene product from transcript CG5327-RA |
Echinococcus granulosus | EgrG_000761700 | protein fam136a |
Echinococcus multilocularis | EmuJ_000761700 | protein fam136a |
Homo sapiens | ENSG00000035141 | family with sequence similarity 136, member A |
Homo sapiens | 100287852 | protein FAM136A-like |
Loa Loa (eye worm) | LOAG_02695 | hypothetical protein |
Mus musculus | ENSMUSG00000057497 | family with sequence similarity 136, member A |
Mus musculus | 102643001 | protein FAM136A-like |
Mus musculus | 102632427 | predicted gene, 30502 |
Neospora caninum | NCLIV_010410 | hypothetical protein, conserved |
Oryza sativa | 4350220 | Os11g0256200 |
Onchocerca volvulus | OVOC7941 |
|
Plasmodium berghei | PBANKA_0310600 | conserved protein, unknown function |
Plasmodium falciparum | PF3D7_0213700 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_0407300 | conserved protein, unknown function |
Plasmodium vivax | PVX_002850 | hypothetical protein, conserved |
Plasmodium yoelii | PY03935 | hypothetical protein |
Schistosoma japonicum | Sjp_0005890 | Protein FAM136A, putative |
Schistosoma mansoni | Smp_066610.1 | hypothetical protein |
Toxoplasma gondii | TGME49_319730 | YOU2 family C2C2 zinc finger protein |
Theileria parva | TP02_0610 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_319730 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.