pI: 6.8647 |
Length (AA): 320 |
MW (Da): 35658 |
Paralog Number:
1
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 314 | 3gir (A) | 60 | 371 | 16.00 | 0 | 1 | 0.9325 | 0.43 |
7 | 303 | 3ttg (A) | 21 | 329 | 21.00 | 0 | 1 | 1.02513 | 0.16 |
55 | 103 | 3nqw (A) | 69 | 111 | 49.00 | 0.25 | 0.65 | 0.462925 | 1.04 |
239 | 295 | 3axa (A) | 26 | 84 | 39.00 | 0.5 | 0.87 | 0.579925 | 0.34 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128882)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G12130 | mitochondrial-type protein COG0354 |
Babesia bovis | BBOV_I001650 | conserved hypothetical protein |
Brugia malayi | Bm1_00450 | aminomethyltransferase |
Candida albicans | CaO19.318 | similar to S. cerevisiae CAF17 (YJR122W) putative CCR4 transcriptional complex associated factor |
Candida albicans | CaO19.7950 | similar to S. cerevisiae CAF17 (YJR122W) putative CCR4 transcriptional complex associated factor |
Caenorhabditis elegans | CELE_F39H2.3 | Protein F39H2.3 |
Dictyostelium discoideum | DDB_G0285011 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8043 | CG8043 gene product from transcript CG8043-RA |
Echinococcus granulosus | EgrG_000187600 | protein of unknown function DUF1279 |
Echinococcus multilocularis | EmuJ_000187600 | protein of unknown function DUF1279 |
Homo sapiens | ENSG00000181873 | IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.24.1800 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_241810.1 | folate-binding protein YgfZ, putative |
Leishmania infantum | LinJ.24.1810 | hypothetical protein, conserved |
Leishmania major | LmjF.24.1740 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.24.1740 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_15192 | aminomethyltransferase |
Loa Loa (eye worm) | LOAG_07189 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11663 | hypothetical protein |
Oryza sativa | 4340033 | Os06g0134800 |
Onchocerca volvulus | OVOC7263 | Putative transferase CAF17, mitochondrial |
Saccharomyces cerevisiae | YJR122W | Iba57p |
Schistosoma japonicum | Sjp_0302650 | ko:K06980 Glycine cleavage T protein, putative |
Schistosoma mansoni | Smp_170950 | hypothetical protein |
Schmidtea mediterranea | mk4.000208.00 | Putative transferase CAF17, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.8.6560 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.6480 | folate-binding protein YgfZ, putative |
Trypanosoma cruzi | TcCLB.506801.110 | folate-binding protein YgfZ, putative |
Trypanosoma cruzi | TcCLB.511907.230 | folate-binding protein YgfZ, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0348 | glycine cleavage system protein T |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6480 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6480 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6480 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.6480 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.