Detailed view for PF3D7_0219200

Basic information

TDR Targets ID: 3452
Plasmodium falciparum, 40S ribosomal protein S30
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 12.4479 | Length (AA): 58 | MW (Da): 6488 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04758   Ribosomal protein S30

Gene Ontology

Mouse over links to read term descriptions.
GO:0022627   cytosolic small ribosomal subunit  
GO:0005840   ribosome  
GO:0005739   mitochondrion  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 58 4kzy (e) 75 133 64.00 0 0.76 1.60152 0.18
13 51 3tdu (A) 136 171 36.00 0.12 0.06 1.10491 -1.55
20 50 2px2 (B) 34 76 32.00 0.85 0.14 0.882983 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127269)

Species Accession Gene Product
Arabidopsis thaliana AT4G29390   40S ribosomal protein S30
Arabidopsis thaliana AT5G56670   40S ribosomal protein S30
Arabidopsis thaliana AT2G19750   40S ribosomal protein S30
Babesia bovis BBOV_III002090   40S ribosomal protein S30, putative
Brugia malayi Bm1_53225   40S ribosomal protein S30
Caenorhabditis elegans CELE_C26F1.4   Protein RPS-30
Cryptosporidium parvum cgd6_3710   40S ribosomal protein S30
Dictyostelium discoideum DDB_G0273743   40S ribosomal protein S30
Dictyostelium discoideum DDB_G0273191   40S ribosomal protein S30
Drosophila melanogaster Dmel_CG15697   Ribosomal protein S30
Echinococcus granulosus EgrG_000855200   small subunit ribosomal protein s30e
Echinococcus granulosus EgrG_000855300   small subunit ribosomal protein s30e
Entamoeba histolytica EHI_044550   Ribosomal protein S30, putative
Entamoeba histolytica EHI_182590   Ribosomal protein S30, putative
Entamoeba histolytica EHI_147710   Ribosomal protein S30, putative
Entamoeba histolytica EHI_023400   Ribosomal protein S30, putative
Entamoeba histolytica EHI_088600   Ribosomal protein S30, putative
Echinococcus multilocularis EmuJ_000855200   small subunit ribosomal protein s30e
Echinococcus multilocularis EmuJ_000855300   small subunit ribosomal protein s30e
Homo sapiens 2197   Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
Leishmania braziliensis LbrM.30.0750   40S ribosomal protein S30, putative
Leishmania braziliensis LbrM.30.0770   40S ribosomal protein S30, putative
Leishmania braziliensis LbrM.30.0760   40S ribosomal protein S30, putative
Leishmania donovani LdBPK_300710.1   40S ribosomal protein S30, putative
Leishmania infantum LinJ.30.0690   40S ribosomal protein S30, putative
Leishmania infantum LinJ.30.0700   40S ribosomal protein S30, putative
Leishmania infantum LinJ.30.0710   40S ribosomal protein S30, putative
Leishmania major LmjF.30.0690   40S ribosomal protein S30, putative
Leishmania major LmjF.30.0670   40S ribosomal protein S30, putative
Leishmania major LmjF.30.0680   40S ribosomal protein S30, putative
Leishmania mexicana LmxM.29.0670   40S ribosomal protein S30, putative
Leishmania mexicana LmxM.29.0690   40S ribosomal protein S30, putative
Loa Loa (eye worm) LOAG_06871   hypothetical protein
Mus musculus ENSMUSG00000038274   Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)
Neospora caninum NCLIV_043250   40S ribosomal protein S30, putative
Oryza sativa 9272265   Os02g0804150
Oryza sativa 4340273   Os06g0172600
Plasmodium berghei PBANKA_0315600   40S ribosomal protein S30, putative
Plasmodium falciparum PF3D7_0219200   40S ribosomal protein S30
Plasmodium knowlesi PKNH_0401700   40S ribosomal protein S30, putative
Plasmodium vivax PVX_002590   40S ribosomal protein S30, putative
Saccharomyces cerevisiae YOR182C   ribosomal 40S subunit protein S30B
Saccharomyces cerevisiae YLR287C-A   ribosomal 40S subunit protein S30A
Schistosoma japonicum Sjp_0024040   ko:K02983 small subunit ribosomal protein S30e, putative
Schistosoma mansoni Smp_014650   40S ribosomal protein S30
Schmidtea mediterranea mk4.000670.08   40S ribosomal protein S30
Trypanosoma brucei gambiense Tbg972.6.1840   40S ribosomal protein S30, putative
Trypanosoma brucei gambiense Tbg972.6.1850   40S ribosomal protein S30, putative
Trypanosoma brucei Tb927.6.2100   40S ribosomal protein S30, putative
Trypanosoma brucei Tb927.6.2110   40S ribosomal protein S30, putative
Trypanosoma cruzi TcCLB.507019.83   40S ribosomal protein S30, putative
Trypanosoma cruzi TcCLB.507019.86   40S ribosomal protein S30, putative
Toxoplasma gondii TGME49_291850   ribosomal protein RPS30
Theileria parva TP03_0566   40S ribosomal protein S30, putative
Trichomonas vaginalis TVAG_393330   40S ribosomal protein S30, putative
Trichomonas vaginalis TVAG_264680   40S ribosomal protein S30, putative
Trichomonas vaginalis TVAG_222910   40S ribosomal protein S30, putative
Trichomonas vaginalis TVAG_407700   40S ribosomal protein S30, putative
Trichomonas vaginalis TVAG_393320   ribosomal protein, small subunit protein, putative
Trichomonas vaginalis TVAG_356480   40S ribosomal protein S30, putative
Trichomonas vaginalis TVAG_476770   ribosomal protein, small subunit protein, putative
Trichomonas vaginalis TVAG_264670   ribosomal protein, small subunit protein, putative

Essentiality

PF3D7_0219200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.2100 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.2100 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.2100 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.2100 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C26F1.4 Caenorhabditis elegans larval arrest wormbase
CELE_C26F1.4 Caenorhabditis elegans slow growth wormbase
YOR182C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0315600 Plasmodium berghei Essential plasmo
TGME49_291850 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0219200 (Plasmodium falciparum), 40S ribosomal protein S30
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