pI: 5.4778 |
Length (AA): 71 |
MW (Da): 8264 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 71 | 1l0l (H) | 10 | 78 | 28.00 | 0 | 0.93 | 1.33983 | -0.23 |
6 | 71 | 3cx5 (F) | 74 | 147 | 24.00 | 0 | 0.95 | 1.17858 | -0.42 |
32 | 71 | 3tgu (H) | 40 | 78 | 38.00 | 0.69 | 0.3 | 0.86428 | 0.79 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128457)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G15120 | ubiquinol-cytochrome C reductase hinge protein |
Babesia bovis | BBOV_II002140 | hypothetical protein |
Brugia malayi | Bm1_14750 | Ubiquinol-cytochrome C reductase hinge protein |
Caenorhabditis elegans | CELE_T27E9.2 | Protein T27E9.2 |
Dictyostelium discoideum | DDB_G0271774 | ubiquinol-cytochrome-c reductase hinge protein |
Drosophila melanogaster | Dmel_CG41623 | Ubiquinol-cytochrome C reductase complex 11 kDa protein |
Drosophila melanogaster | Dmel_CG30354 | CG30354 gene product from transcript CG30354-RB |
Echinococcus granulosus | EgrG_000595900 | ubiquinol cytochrome c oxidoreductase subunit 6 |
Echinococcus multilocularis | EmuJ_000595900 | ubiquinol cytochrome c oxidoreductase subunit 6 |
Homo sapiens | ENSG00000173660 | ubiquinol-cytochrome c reductase hinge protein |
Homo sapiens | 440567 | ubiquinol-cytochrome c reductase hinge protein-like |
Leishmania braziliensis | LbrM.31.2920 | ubiquinol-cytochrome-c reductase-like protein |
Leishmania donovani | LdBPK_312650.1 | ubiquinol-cytochrome-c reductase-like protein |
Leishmania infantum | LinJ.31.2650 | ubiquinol-cytochrome-c reductase-like protein |
Leishmania major | LmjF.31.2580 | ubiquinol-cytochrome-c reductase-like protein |
Leishmania mexicana | LmxM.30.2580 | ubiquinol-cytochrome-c reductase-like protein |
Loa Loa (eye worm) | LOAG_06463 | filarial common antigen |
Mus musculus | ENSMUSG00000063882 | ubiquinol-cytochrome c reductase hinge protein |
Neospora caninum | NCLIV_010110 | hypothetical protein |
Oryza sativa | 4349859 | Os11g0162200 |
Plasmodium berghei | PBANKA_1017700 | cytochrome b-c1 complex subunit 6, putative |
Plasmodium falciparum | PF3D7_1426900 | cytochrome b-c1 complex subunit 6, putative |
Plasmodium knowlesi | PKNH_1331800 | cytochrome b-c1 complex subunit 6, putative |
Plasmodium vivax | PVX_085190 | ubiquinol-cytochrome c reductase hinge protein, putative |
Plasmodium yoelii | PY01064 | ubiquinol-cytochrome c reductase complex 7.8 kDa protein |
Saccharomyces cerevisiae | YFR033C | ubiquinol--cytochrome-c reductase subunit 6 |
Schistosoma japonicum | Sjp_0057180 | IPR003422,Ubiquinol-cytochrome C reductase hinge protein,domain-containing |
Schistosoma mansoni | Smp_059930 | hypothetical protein |
Schmidtea mediterranea | mk4.001031.00 | |
Schmidtea mediterranea | mk4.000656.00 | |
Trypanosoma brucei gambiense | Tbg972.4.5170 | ubiquinol-cytochrome c reductase, putative |
Trypanosoma brucei | Tb927.8.7430 | ubiquinol-cytochrome c reductase, putative |
Trypanosoma brucei | Tb927.4.4990 | ubiquinol-cytochrome c reductase, putative |
Trypanosoma cruzi | TcCLB.504575.15 | ubiquinol-cytochrome-C-reductase, putative |
Trypanosoma cruzi | TcCLB.509011.54 | ubiquinol-cytochrome c reductase, putative |
Toxoplasma gondii | TGME49_320140 | ubiquinol-cytochrome c reductase hinge protein, putative |
Theileria parva | TP04_0347 | ubiquinol-cytochrome C reductase hinge protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.4990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.4990 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.4990 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.4990 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T27E9.2 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1017700 | Plasmodium berghei | Essential | plasmo |
TGME49_320140 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | cytochrome b-c1 complex subunit 6, putative | Compounds | References |