Detailed view for TcCLB.503823.160

Basic information

TDR Targets ID: 34909
Trypanosoma cruzi, ubiquinone biosynthesis methyltransferase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.5055 | Length (AA): 290 | MW (Da): 32668 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01209   ubiE/COQ5 methyltransferase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 175 1l3i (A) 22 133 24.00 0.0000066 0.81 0.67 -0.93
47 288 1xxl (A) 2 208 24.00 0 1 0.86 -0.22
24 255 4obx (A) 73 306 49.00 0 1 1.4074 -1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127211)

Species Accession Gene Product
Arabidopsis thaliana AT5G57300   2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Babesia bovis BBOV_III009020   ubiquinone/menaquinone biosynthesis methyltransferases family protein
Brugia malayi Bm1_26350   Ubiquinone biosynthesis methyltransferase ZK652.9, putative
Candida albicans CaO19.3577   putative mitochondrial C-methyltransferase
Candida albicans CaO19.11061   putative mitochondrial C-methyltransferase
Caenorhabditis elegans CELE_ZK652.9   Protein COQ-5
Cryptosporidium hominis Chro.10320   hypothetical protein
Cryptosporidium parvum cgd1_2860   hypothetical protein
Chlamydia trachomatis CT_428   demethylmenaquinone methyltransferase
Dictyostelium discoideum DDB_G0280237   ubiE/COQ5 methyltransferase family protein
Drosophila melanogaster Dmel_CG2453   CG2453 gene product from transcript CG2453-RC
Escherichia coli b3833   bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase/S-adenosylmethionine:2-DMK methyltransferase
Echinococcus granulosus EgrG_000905300   2 methoxy 6 polyprenyl 14 benzoquinol
Echinococcus multilocularis EmuJ_000905300   2 methoxy 6 polyprenyl 1,4 benzoquinol
Homo sapiens ENSG00000110871   coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
Leishmania braziliensis LbrM.35.5610   ubiquinone biosynthesis methyltransferase, putative
Leishmania donovani LdBPK_365590.1   ubiquinone biosynthesis methyltransferase, putative
Leishmania infantum LinJ.36.5590   ubiquinone biosynthesis methyltransferase, putative
Leishmania major LmjF.36.5360   ubiquinone biosynthesis methyltransferase, putative
Leishmania mexicana LmxM.36.5360   ubiquinone biosynthesis methyltransferase, putative
Loa Loa (eye worm) LOAG_00003   ubiquinone biosynthesis methyltransferase
Mycobacterium leprae ML2273   PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase)
Mus musculus ENSMUSG00000041733   coenzyme Q5 homolog, methyltransferase (yeast)
Mycobacterium tuberculosis Rv0558   Probable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone methyltransferase)
Mycobacterium ulcerans MUL_0660   ubiquinone/menaquinone biosynthesis methyltransferase
Mycobacterium ulcerans MUL_0820   methyltransferase
Neospora caninum NCLIV_002130   ubiquinone/menaquinone biosynthesis methyltransferae, putative
Oryza sativa 4324310   Os01g0976600
Plasmodium berghei PBANKA_0302700   methyltransferase, putative
Plasmodium falciparum PF3D7_0204900   ubiE/COQ5 methyltransferase, putative
Plasmodium knowlesi PKNH_0416000   DEAD/DEAH box helicase, putative
Plasmodium vivax PVX_003675   ubiquinone biosynthesis methyltransferase, putative
Plasmodium yoelii PY00901   methlytransferase, UbiE/COQ5 family
Saccharomyces cerevisiae YML110C   2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
Schistosoma japonicum Sjp_0105150   ko:K00599 methyltransferase [EC:2.1.1.-], putative
Schistosoma mansoni Smp_021910   ubiquinone/menaquinone biosynthesis methyltransferase
Schmidtea mediterranea mk4.003844.02   2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Schmidtea mediterranea mk4.003844.01   2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Trypanosoma brucei gambiense Tbg972.11.11780   ubiquinone biosynthesis methyltransferase, putative
Trypanosoma brucei Tb927.11.10510   ubiquinone biosynthesis methyltransferase, putative
Trypanosoma congolense TcIL3000.11.11100   ubiquinone biosynthesis methyltransferase, putative
Trypanosoma congolense TcIL3000_0_52950   ubiquinone biosynthesis methyltransferase, putative
Trypanosoma cruzi TcCLB.503823.160   ubiquinone biosynthesis methyltransferase, putative
Trypanosoma cruzi TcCLB.510285.60   ubiquinone biosynthesis methyltransferase, putative
Toxoplasma gondii TGME49_295690   ubiquinone/menaquinone biosynthesis methyltransferase subfamily protein
Theileria parva TP04_0806   ubiquinone/menaquinone biosynthesis methyltransferase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0202   ubiquinone/menaquinone biosynthesis methylase

Essentiality

TcCLB.503823.160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu566 Mycobacterium tuberculosis essential nmpdr
Tb11.01.2280 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.2280 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.2280 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.2280 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3833 Escherichia coli essential goodall
PBANKA_0302700 Plasmodium berghei Essential plasmo
TGME49_295690 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.503823.160 (Trypanosoma cruzi), ubiquinone biosynthesis methyltransferase, putative
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