Detailed view for PF3D7_0302500

Basic information

TDR Targets ID: 3525
Plasmodium falciparum, cytoadherence linked asexual protein 3.1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.1681 | Length (AA): 1417 | MW (Da): 167242 | Paralog Number: 4

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03805   Cytoadherence-linked asexual protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0050839   cell adhesion molecule binding  
GO:0020035   cytoadherence to microvasculature, mediated by parasite protein  
GO:0020002   host cell plasma membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 225 4tql (A) 23 238 13.00 0.23 0.05 0.189186 -0.16
64 234 4uos (A) 1 175 20.00 0.037 0.41 0.296177 -0.65
98 232 3u9j (A) 19 153 27.00 0.3 0.63 0.179072 0.1
537 712 1a8d (A) 205 372 28.00 0.68 0.02 -0.115994 2.73
41 223 4uos (A) 0 184 19.00 0.072 0.56 0.374641 -1.02
72 818 4ifq (A) 26 920 17.00 0.062 0.92 0.360747 1.02
98 232 3u9j (A) 19 153 28.00 0.15 0.63 0.176353 0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, early schizont, late schizont, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 16 hs, sporozoite, early ring, early trophozoite, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, late ring, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Oocyst, Female Gametocyte, Male Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_138272)

Species Accession Gene Product
Plasmodium berghei PBANKA_0836300   cytoadherence linked asexual protein 9
Plasmodium berghei PBANKA_1400600   cytoadherence linked asexual protein, putative
Plasmodium falciparum PF3D7_0831600   cytoadherence linked asexual protein 8
Plasmodium falciparum PF3D7_0220800   cytoadherence linked asexual protein 2
Plasmodium falciparum PF3D7_0935800   cytoadherence linked asexual protein 9
Plasmodium falciparum PF3D7_0302200   cytoadherence linked asexual protein 3.2
Plasmodium falciparum PF3D7_0302500   cytoadherence linked asexual protein 3.1
Plasmodium knowlesi PKNH_1401300   cytoadherence linked asexual protein, putative
Plasmodium knowlesi PKNH_0734400   cytoadherence linked asexual protein, CLAG, putative
Plasmodium vivax PVX_121885   cytoadherence linked asexual protein, CLAG, putative
Plasmodium vivax PVX_094265   cytoadherence-linked asexual protein (CLAG), putative
Plasmodium yoelii PY04666   PyRhopH1A-related
Plasmodium yoelii PY06117   PyRhopHA1 paralog
Plasmodium yoelii PY02932   PyRhopH1A-related

Essentiality

PF3D7_0302500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0836300 Plasmodium berghei Essential plasmo
PBANKA_1400600 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0302500 (Plasmodium falciparum), cytoadherence linked asexual protein 3.1
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