Detailed view for TcCLB.504411.20

Basic information

TDR Targets ID: 35466
Trypanosoma cruzi, divalent cation tolerance protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.8302 | Length (AA): 105 | MW (Da): 11835 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03091   CutA1 divalent ion tolerance protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0010038   response to metal ion  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 103 1nza (A) 1 103 43.00 0 1 1.66 -1.53
1 103 1nza (A) 1 103 43.00 0 1 1.59165 -0.87
2 103 4iyq (A) 5 106 35.00 0 0.94 1.50283 -1.06
3 101 3gsd (A) 19 117 35.00 0 0.99 1.47856 -0.93
3 103 2zom (A) 11 111 46.00 0 1 1.6066 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128186)

Species Accession Gene Product
Arabidopsis thaliana AT2G33740   copper binding protein CutA
Brugia malayi Bm1_33805   CutA1 divalent ion tolerance protein
Caenorhabditis elegans CELE_F35G12.7   Protein F35G12.7
Cryptosporidium hominis Chro.60280   divalent cation tolerance protein
Cryptosporidium parvum cgd6_2410   possible CutA1 divalent ion tolerance protein
Drosophila melanogaster Dmel_CG11590   CG11590 gene product from transcript CG11590-RA
Escherichia coli b4137   divalent-cation tolerance protein, copper sensitivity
Homo sapiens ENSG00000112514   cutA divalent cation tolerance homolog (E. coli)
Loa Loa (eye worm) LOAG_05021   CutA1 divalent ion tolerance protein
Mus musculus ENSMUSG00000024194   cutA divalent cation tolerance homolog (E. coli)
Mus musculus ENSMUSG00000026870   cutA divalent cation tolerance homolog-like
Neospora caninum NCLIV_047800   hypothetical protein
Oryza sativa 4348499   Os10g0378300
Oryza sativa 9267187   Os03g0186950
Onchocerca volvulus OVOC2794   Protein CutA homolog
Plasmodium berghei PBANKA_1462400   cutA, putative
Plasmodium falciparum PF3D7_1249500   cutA, putative
Plasmodium knowlesi PKNH_1469200   cutA homologue, putative
Plasmodium vivax PVX_101362   cutA, putative
Schistosoma japonicum Sjp_0213110   ko:K03926 periplasmic divalent cation tolerance protein, putative
Schistosoma mansoni Smp_048870   divalent cation tolerance cuta-related
Schmidtea mediterranea mk4.000315.10   Protein CutA
Schmidtea mediterranea mk4.000488.02  
Trypanosoma brucei gambiense Tbg972.4.4410   divalent cation tolerance protein, putative
Trypanosoma brucei Tb927.4.4320   divalent cation tolerance protein, putative
Trypanosoma congolense TcIL3000_8_8220   divalent cation tolerance protein, putative
Trypanosoma congolense TcIL3000_8_8090   divalent cation tolerance protein, putative
Trypanosoma congolense TcIL3000_4_3660   divalent cation tolerance protein, putative
Trypanosoma cruzi TcCLB.504717.10   divalent cation tolerance protein, putative
Trypanosoma cruzi TcCLB.505009.20   divalent cation tolerance protein, putative
Trypanosoma cruzi TcCLB.504411.20   divalent cation tolerance protein, putative
Trypanosoma cruzi TcCLB.506489.59   divalent cation tolerance protein, putative
Toxoplasma gondii TGME49_224910   divalent cation tolerance protein, CutA1 family protein
Wolbachia endosymbiont of Brugia malayi Wbm0766   hypothetical protein

Essentiality

TcCLB.504411.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.4320 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.4320 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.4320 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.4320 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b4137 Escherichia coli non-essential goodall
TGME49_224910 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.504411.20 (Trypanosoma cruzi), divalent cation tolerance protein, putative
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