Detailed view for PF3D7_0305800

Basic information

TDR Targets ID: 3559
Plasmodium falciparum, P-loop containing nucleoside triphosphate hydrolase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.8397 | Length (AA): 1114 | MW (Da): 132198 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05186   Dpy-30 motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0019205   nucleobase, nucleoside, nucleotide kinase activity  
GO:0006139   nucleobase, nucleoside, nucleotide and nucleic acid metabolic process  
GO:0005524   ATP binding  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
532 725 1zak (A) 4 192 19.00 0 0.98 0.28 0.68
534 636 1tev (A) 4 99 29.00 0.55 0.94 0.41506 -0.19
683 824 3fby (A) 350 513 34.00 0.0000092 0.01 0.363069 -0.75
701 866 2ap3 (A) 14 187 25.00 0.084 0.01 0.526613 -1.97
845 1058 4tql (A) 10 229 26.00 0.25 0.5 0.315701 0.16
851 1080 4tql (A) 10 238 21.00 0.00011 0.56 0.422963 -0.19
926 1112 4uos (A) 3 183 20.00 0.042 0.6 0.426364 -1.17
928 1060 4u5a (A) 69 234 35.00 0.74 0.11 0.14199 0.68
1028 1093 4rta (B) 30 101 39.00 0.0018 0.24 0.377846 0.55
661 776 2fkj (A) 117 246 33.00 0.66 0.03 0.405463 -1.27
678 854 2ap3 (A) 5 187 27.00 0.049 0 0.482817 -1.52
843 1072 4tql (A) 14 235 20.00 0.0015 0.67 0.420211 -0.19
912 1100 4uos (A) 2 183 20.00 0.013 0.29 0.404006 -1.18
1016 1081 4rta (B) 30 101 39.00 0.0018 0.24 0.379091 0.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst, Ring. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_130764)

Species Accession Gene Product
Echinococcus granulosus EgrG_000519400   adenylate kinase 7
Echinococcus granulosus EgrG_000707300   adenylate kinase 7
Echinococcus multilocularis EmuJ_000519400   adenylate kinase 7
Echinococcus multilocularis EmuJ_000707300   adenylate kinase 7
Homo sapiens ENSG00000140057   adenylate kinase 7
Leishmania braziliensis LbrM.13.1120   hypothetical protein, conserved
Leishmania donovani LdBPK_131250.1   AAA domain/Dpy-30 motif containing protein, putative
Leishmania infantum LinJ.13.1250   hypothetical protein, conserved
Leishmania major LmjF.13.1350   hypothetical protein, conserved
Leishmania mexicana LmxM.13.1350   hypothetical protein, conserved
Mus musculus ENSMUSG00000041323   adenylate kinase 7
Neospora caninum NCLIV_030980   dpy-30 motif-containing protein, putative
Plasmodium berghei PBANKA_0404300   P-loop containing nucleoside triphosphate hydrolase, putative
Plasmodium falciparum PF3D7_0305800   P-loop containing nucleoside triphosphate hydrolase, putative
Plasmodium knowlesi PKNH_0836900   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_119415   hypothetical protein, conserved
Plasmodium yoelii PY05887   Plasmodium vivax PV1H14210_P
Schistosoma japonicum Sjp_0006240   ko:K00939 adenylate kinase [EC2.7.4.3], putative
Schistosoma mansoni Smp_163660   hypothetical protein
Schmidtea mediterranea mk4.001189.00   Adenylate kinase 7
Trypanosoma brucei gambiense Tbg972.11.3960   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.3500   Dpy-30 motif containing protein, putative
Trypanosoma congolense TcIL3000.11.3440   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507629.30   Dpy-30 motif containing protein, putative
Toxoplasma gondii TGME49_230460   Dpy-30 motif protein
Trichomonas vaginalis TVAG_282000   adenylate kinase, putative
Trichomonas vaginalis TVAG_372350   adenylate kinase, putative

Essentiality

PF3D7_0305800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.0990 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.0990 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.0990 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.0990 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0404300 Plasmodium berghei Dispensable plasmo
TGME49_230460 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0305800 (Plasmodium falciparum), P-loop containing nucleoside triphosphate hydrolase, putative
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