pI: 4.6651 |
Length (AA): 141 |
MW (Da): 15396 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 139 | 1e7k (A) | 4 | 123 | 22.00 | 0 | 0.95 | 1.22 | -0.72 |
11 | 140 | 1xbi (A) | 3 | 116 | 27.00 | 0 | 1 | 1.12 | -0.78 |
15 | 138 | 2aif (A) | 17 | 130 | 19.00 | 0 | 1 | 1.07 | -1.26 |
10 | 141 | 3pla (C) | 7 | 126 | 23.00 | 0 | 1 | 1.23567 | -0.79 |
10 | 141 | 2fc3 (A) | 4 | 123 | 25.00 | 0 | 0.91 | 1.27227 | -1.05 |
13 | 114 | 4bw0 (B) | 7 | 109 | 29.00 | 0.00014 | 0.99 | 1.1115 | -1.18 |
17 | 138 | 4kzy (M) | 10 | 130 | 45.00 | 0 | 1 | 1.37895 | -0.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, late ring, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | merozoite, early schizont, early trophozoite, late trophozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | gametocyte. | PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127261)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G15930 | 40S ribosomal protein S12-1 |
Arabidopsis thaliana | AT2G32060 | 40S ribosomal protein S12-2 |
Babesia bovis | BBOV_III001100 | 40S ribosomal protein S12, putative |
Brugia malayi | Bm1_55385 | 40S ribosomal protein S12 |
Candida albicans | CaO19.14077 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS12 (YOR369C) small subunit protein S12 |
Candida albicans | CaO19.6785 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS12 (YOR369C) small subunit protein S12 |
Caenorhabditis elegans | CELE_F54E7.2 | Protein RPS-12 |
Cryptosporidium hominis | Chro.50479 | ribosomal protein S12 |
Cryptosporidium parvum | cgd5_3740 | 40S ribosomal protein S12. pelota RNA binding domain containing protein |
Dictyostelium discoideum | DDB_G0284237 | 40S ribosomal protein S12 |
Drosophila melanogaster | Dmel_CG11271 | Ribosomal protein S12 |
Echinococcus granulosus | EgrG_000209000 | 40S ribosomal protein S12 |
Entamoeba histolytica | EHI_111760 | 40S ribosomal protein S12, putative |
Entamoeba histolytica | EHI_153330 | 40S ribosomal protein S12, putative |
Echinococcus multilocularis | EmuJ_000209000 | ribosomal protein S12 |
Giardia lamblia | GL50803_33862 | Ribosomal protein S12 |
Homo sapiens | 6206 | ribosomal protein S12 |
Leishmania braziliensis | LbrM.13.0390 | 40S ribosomal protein S12, putative |
Leishmania donovani | LdBPK_130460.1 | 40S ribosomal protein S12, putative |
Leishmania infantum | LinJ.13.0460 | 40S ribosomal protein S12, putative |
Leishmania major | LmjF.13.0570 | 40S ribosomal protein S12, putative |
Leishmania mexicana | LmxM.13.0570 | 40S ribosomal protein S12, putative |
Loa Loa (eye worm) | LOAG_05517 | 40S ribosomal protein S12 |
Mus musculus | 100862223 | predicted gene, 21571 |
Mus musculus | ENSMUSG00000061983 | ribosomal protein S12 |
Neospora caninum | NCLIV_020360 | 40S ribosomal protein S12, related |
Oryza sativa | 4342771 | Os07g0229900 |
Oryza sativa | 4342408 | Os07g0150200 |
Plasmodium berghei | PBANKA_0405400 | 40S ribosomal protein S12, putative |
Plasmodium falciparum | PF3D7_0307100 | 40S ribosomal protein S12, putative |
Plasmodium knowlesi | PKNH_0835600 | 40S ribosomal protein S12, putative |
Plasmodium vivax | PVX_119475 | 40S ribosomal protein S12, putative |
Plasmodium yoelii | PY05755 | 40S ribosomal protein S12 |
Saccharomyces cerevisiae | YOR369C | ribosomal 40S subunit protein S12 |
Schistosoma japonicum | Sjp_0040720 | ko:K02951 small subunit ribosomal protein S12e, putative |
Schistosoma mansoni | Smp_060090.2 | 40S ribosomal protein S12 |
Schmidtea mediterranea | mk4.008691.01 | |
Schmidtea mediterranea | mk4.003775.00 | |
Trypanosoma brucei gambiense | Tbg972.11.4910 | 40S ribosomal protein S12, putative |
Trypanosoma brucei | Tb927.11.4290 | 40S ribosomal protein S12 |
Trypanosoma congolense | TcIL3000.11.4340 | 40S ribosomal protein S12, putative |
Trypanosoma cruzi | TcCLB.503395.50 | 40S ribosomal protein S12, putative |
Trypanosoma cruzi | TcCLB.506181.59 | 40S ribosomal protein S12, putative |
Toxoplasma gondii | TGME49_205340 | ribosomal protein RPS12 |
Theileria parva | TP03_0717 | 40S ribosomal protein S12, putative |
Trichomonas vaginalis | TVAG_464050 | 40S ribosomal protein S12, putative |
Trichomonas vaginalis | TVAG_010250 | 40S ribosomal protein S12, putative |
Trichomonas vaginalis | TVAG_120740 | 40S ribosomal protein S12, putative |
Trichomonas vaginalis | TVAG_120980 | 40S ribosomal protein S12, putative |
Trichomonas vaginalis | TVAG_224610 | 40S ribosomal protein S12, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.1830 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.1830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.1830 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.1830 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F54E7.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54E7.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54E7.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F54E7.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F54E7.2 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0405400 | Plasmodium berghei | Essential | plasmo |
TGME49_205340 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.