Detailed view for PF3D7_0307200

Basic information

TDR Targets ID: 3572
Plasmodium falciparum, 60S ribosomal protein L7, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 11.0063 | Length (AA): 257 | MW (Da): 30523 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00327   Ribosomal protein L30p/L7e
PF08079   Ribosomal L30 N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0015934   large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0030528   transcription regulator activity  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
92 256 1vq8 (W) 1 153 19.00 0 1 0.8 -1.2
4 71 4tql (A) 91 158 22.00 0.19 0 0.592491 -1.17
92 256 1vq8 (W) 1 153 19.00 0.00000021 0.99 0.934923 -1.03
97 256 1vq8 (W) 6 153 19.00 0 1 0.833168 -0.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, merozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile late schizont. PlasmoDB
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_126953)

Species Accession Gene Product
Arabidopsis thaliana AT2G44120   60S ribosomal protein L7-3
Arabidopsis thaliana AT3G13580   60S ribosomal protein L7-4
Babesia bovis BBOV_III000980   60S ribosomal protein L7, putative
Brugia malayi Bm1_24400   60S ribosomal protein L7
Caenorhabditis elegans CELE_F53G12.10   Protein RPL-7
Cryptosporidium hominis Chro.80499   60S ribosomal protein L7
Cryptosporidium parvum cgd8_4350   60S ribosomal protein L7
Dictyostelium discoideum DDB_G0276441   S60 ribosomal protein L7
Drosophila melanogaster Dmel_CG4897   Ribosomal protein L7
Echinococcus granulosus EgrG_001122900   large subunit ribosomal protein l7e
Entamoeba histolytica EHI_146530   60S ribosomal protein L7, putative
Entamoeba histolytica EHI_010650   60S ribosomal protein L7, putative
Entamoeba histolytica EHI_025830   60S ribosomal protein L7, putative
Entamoeba histolytica EHI_192110   60S ribosomal protein L7, putative
Echinococcus multilocularis EmuJ_001122900   large subunit ribosomal protein l7e
Giardia lamblia GL50803_19436   Ribosomal protein L7
Homo sapiens ENSG00000147604   ribosomal protein L7
Leishmania braziliensis LbrM.26.0160   60S ribosomal protein L7, putative
Leishmania braziliensis LbrM.26.0170   60S ribosomal protein L7, putative
Leishmania donovani LdBPK_260160.1   60S ribosomal protein L7, putative
Leishmania infantum LinJ.26.0160   60S ribosomal protein L7, putative
Leishmania infantum LinJ.26.0150   60S ribosomal protein L7, putative
Leishmania major LmjF.26.0180   60S ribosomal protein L7, putative
Leishmania major LmjF.26.0170   60S ribosomal protein L7, putative
Leishmania mexicana LmxM.26.0180   60S ribosomal protein L7, putative
Leishmania mexicana LmxM.26.0170   60S ribosomal protein L7, putative
Loa Loa (eye worm) LOAG_05190   60S ribosomal protein L7
Mus musculus ENSMUSG00000043716   ribosomal protein L7
Neospora caninum NCLIV_057700   hypothetical protein
Oryza sativa 4345009   Os08g0234000
Oryza sativa 4336914   Os04g0605900
Plasmodium berghei PBANKA_0405500   60S ribosomal protein L7, putative
Plasmodium falciparum PF3D7_0307200   60S ribosomal protein L7, putative
Plasmodium knowlesi PKNH_0835500   60S ribosomal protein L7, putative
Plasmodium vivax PVX_119480   60S ribosomal protein L7, putative
Plasmodium yoelii PY05756   putative 60S Ribosomal protein L7
Saccharomyces cerevisiae YPL198W   ribosomal 60S subunit protein L7B
Saccharomyces cerevisiae YGL076C   ribosomal 60S subunit protein L7A
Schistosoma japonicum Sjp_0080800   ko:K02937 large subunit ribosomal protein L7e, putative
Schistosoma mansoni Smp_101450   60S ribosomal protein L7
Schmidtea mediterranea mk4.001722.05   60S ribosomal protein L7
Trypanosoma brucei gambiense Tbg972.7.1740   60S ribosomal protein L7, putative
Trypanosoma brucei gambiense Tbg972.7.1750   60S ribosomal protein L7, putative
Trypanosoma brucei Tb927.7.1750   60S ribosomal protein L7, putative
Trypanosoma brucei Tb927.7.1740   60S ribosomal protein L7, putative
Trypanosoma brucei Tb927.7.1730   60S ribosomal protein L7, putative
Trypanosoma congolense TcIL3000_0_32580   60S ribosomal protein L7, putative
Trypanosoma cruzi TcCLB.507519.110   60S ribosomal protein L7, putative
Trypanosoma cruzi TcCLB.508207.110   60S ribosomal protein L7, putative
Trypanosoma cruzi TcCLB.508207.100   60S ribosomal protein L7, putative
Toxoplasma gondii TGME49_314810   ribosomal protein RPL7
Theileria parva TP03_0744   60S ribosomal protein L7, putative
Trichomonas vaginalis TVAG_054130   60S ribosomal protein L7, putative
Trichomonas vaginalis TVAG_159370   60S ribosomal protein L7, putative
Trichomonas vaginalis TVAG_067980   60S ribosomal protein L7, putative

Essentiality

PF3D7_0307200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.1730 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.1730 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.1730 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.1730 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F53G12.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_F53G12.10 Caenorhabditis elegans larval arrest wormbase
CELE_F53G12.10 Caenorhabditis elegans slow growth wormbase
CELE_F53G12.10 Caenorhabditis elegans sterile wormbase
TGME49_314810 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0307200 (Plasmodium falciparum), 60S ribosomal protein L7, putative
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