Detailed view for TcCLB.504069.120

Basic information

TDR Targets ID: 36066
Trypanosoma cruzi, amino acid permease 24, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.0459 | Length (AA): 476 | MW (Da): 52777 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01490   Transmembrane amino acid transporter protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
71 458 2a65 (A) 10 466 11.00 0.00000000013 0.05 0.93 -2.05
71 417 5j4i (A) 11 375 17.00 0 0.14 0.817792 -0.14
330 407 3p5n (A) 19 102 29.00 0 0.06 0.0866655 1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127000)

Species Accession Gene Product
Arabidopsis thaliana AT4G38250   transmembrane amino acid transporter family protein
Arabidopsis thaliana AT2G42005   transmembrane amino acid transporter family protein
Arabidopsis thaliana AT5G65990   transmembrane amino acid transporter family protein
Brugia malayi Bm1_41420   protein T27A1.5
Candida albicans CaO19.6984   potential second version of transmembrane amino acid transporter that controls efflux of large neutral amino acids in vacuolar-l
Candida albicans CaO19.1142   similar to transmembrane amino acid transporter that controls efflux of large neutral amino acids in vacuolar-like organelles
Candida albicans CaO19.8735   similar to transmembrane amino acid transporter that controls efflux of large neutral amino acids in vacuolar-like organelles
Caenorhabditis elegans CELE_T27A1.5   Protein T27A1.5, isoform B
Caenorhabditis elegans CELE_Y43F4B.7   Protein Y43F4B.7
Cryptosporidium hominis Chro.70533   hypothetical protein
Cryptosporidium parvum cgd7_4800   ABC transporter, amino acid transporter 12 transmembrane spanning subunit
Dictyostelium discoideum DDB_G0293074   hypothetical protein
Drosophila melanogaster Dmel_CG4991   CG4991 gene product from transcript CG4991-RF
Drosophila melanogaster Dmel_CG43693   CG43693 gene product from transcript CG43693-RD
Drosophila melanogaster Dmel_CG13384   CG13384 gene product from transcript CG13384-RD
Echinococcus granulosus EgrG_000983500   Proton coupled amino acid transporter 1
Echinococcus multilocularis EmuJ_000983500   Proton coupled amino acid transporter 1
Homo sapiens ENSG00000123643   solute carrier family 36 (proton/amino acid symporter), member 1
Homo sapiens ENSG00000180773   solute carrier family 36 (proton/amino acid symporter), member 4
Homo sapiens ENSG00000186335   solute carrier family 36 (proton/amino acid symporter), member 2
Leishmania braziliensis LbrM.10.0840   amino acid transporter, putative
Leishmania braziliensis LbrM.35.1500   amino acid transporter
Leishmania donovani LdBPK_100760.1   amino acid permease 24
Leishmania donovani LdBPK_100770.1   amino acid permease 24
Leishmania infantum LinJ.10.0760   amino acid transporter, putative
Leishmania infantum LinJ.10.0770   amino acid transporter, putative
Leishmania major LmjF.10.0720   amino acid transporter, putative
Leishmania major LmjF.10.0715   amino acid transporter, putative
Leishmania major LmjF.10.0710   amino acid transporter, putative
Leishmania mexicana LmxM.10.0720   amino acid transporter, putative
Loa Loa (eye worm) LOAG_05400   hypothetical protein
Mus musculus ENSMUSG00000020264   solute carrier family 36 (proton/amino acid symporter), member 2
Mus musculus ENSMUSG00000020261   solute carrier family 36 (proton/amino acid symporter), member 1
Mus musculus ENSMUSG00000043885   solute carrier family 36 (proton/amino acid symporter), member 4
Neospora caninum NCLIV_045690   hypothetical protein
Neospora caninum NCLIV_045730   hypothetical protein, conserved
Neospora caninum NCLIV_045700   transmembrane amino acid transporter domain- containing protein, putative
Oryza sativa 4342775   Os07g0231400
Oryza sativa 4330274   Os02g0670900
Oryza sativa 4334572   Os03g0817200
Oryza sativa 4336684   Os04g0565500
Onchocerca volvulus OVOC8753  
Saccharomyces cerevisiae YKL146W   Avt3p
Saccharomyces cerevisiae YNL101W   Avt4p
Schistosoma japonicum Sjp_0310360   Proton-coupled amino acid transporter 4, putative
Schistosoma japonicum Sjp_0213090   Proton-coupled amino acid transporter 4, putative
Schistosoma mansoni Smp_029360   amino acid transporter
Schmidtea mediterranea mk4.009229.00   Amino acid transporter, putative
Schmidtea mediterranea mk4.021624.00   Amino acid transporter, putative
Schmidtea mediterranea mk4.028704.00   Amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.10.7020   amino acid tansporter, putative
Trypanosoma brucei gambiense Tbg972.8.5420   amino acid transporter, putative
Trypanosoma brucei Tb927.10.5780   amino acid tansporter, putative
Trypanosoma brucei Tb927.8.5450   amino acid permease 24
Trypanosoma congolense TcIL3000_8_5260   amino acid permease 24, putative
Trypanosoma congolense TcIL3000_10_4830   amino acid tansporter, putative
Trypanosoma cruzi TcCLB.504229.110   amino acid permease 24, putative
Trypanosoma cruzi TcCLB.509733.160   amino acid tansporter, putative
Trypanosoma cruzi TcCLB.504069.120   amino acid permease 24, putative
Toxoplasma gondii TGME49_227570   transmembrane amino acid transporter protein
Toxoplasma gondii TGME49_227580   transmembrane amino acid transporter protein
Toxoplasma gondii TGME49_227430   transmembrane amino acid transporter protein

Essentiality

TcCLB.504069.120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.5450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.5450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.5450 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.5450 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.5780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.5780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.5780 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.5780 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_227570 Toxoplasma gondii Probably non-essential sidik
TGME49_227430 Toxoplasma gondii Probably non-essential sidik
TGME49_227580 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TcCLB.504069.120 (Trypanosoma cruzi), amino acid permease 24, putative
Title for this comment
Comment