Detailed view for Chro.60083

Basic information

TDR Targets ID: 362825
Cryptosporidium hominis, protein kinase domain
Source Database / ID: 

pI: 6.9661 | Length (AA): 222 | MW (Da): 26339 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 219 3war (A) 115 333 63.00 0 1 1.84599 -1.62
1 217 4rlk (A) 115 331 67.00 0 1 1.87398 -1.59
4 219 4jr7 (A) 157 372 59.00 0 1 1.81277 -1.64
184 213 2i6l (A) 290 319 33.00 0 0.25 0.338635 1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126901)

Species Accession Gene Product
Arabidopsis thaliana AT3G50000   casein kinase II, alpha chain 2
Arabidopsis thaliana AT2G23070   casein kinase 2, alpha polypeptide
Arabidopsis thaliana AT5G67380   casein kinase II subunit alpha-1
Arabidopsis thaliana AT2G23080   casein kinase II alpha chain 3
Babesia bovis BBOV_III007790   casein kinase II, alpha chain (CK II)
Brugia malayi Bm1_49830   Casein kinase II, alpha chain
Candida albicans CaO19.11014   Casein kinase II alpha' subunit
Candida albicans CaO19.3530   Casein kinase II alpha' subunit
Candida albicans CaO19.7652   likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II
Caenorhabditis elegans CELE_B0205.7   Protein KIN-3
Cryptosporidium hominis Chro.60083   protein kinase domain
Cryptosporidium parvum cgd6_620   casein kinase II, alpha subunit, putative
Dictyostelium discoideum DDB_G0276885   CK2 family protein kinase
Drosophila melanogaster Dmel_CG17520   casein kinase IIalpha
Echinococcus granulosus EgrG_000457900   casein kinase ii subunit alpha
Entamoeba histolytica EHI_038670   protein kinase domain containing protein
Entamoeba histolytica EHI_006800   casein kinase, putative
Echinococcus multilocularis EmuJ_000457900   casein kinase ii subunit alpha
Giardia lamblia GL50803_27520   Kinase, CMGC CK2
Homo sapiens ENSG00000254598   casein kinase 2, alpha 3 polypeptide
Homo sapiens ENSG00000070770   casein kinase 2, alpha prime polypeptide
Homo sapiens ENSG00000101266   casein kinase 2, alpha 1 polypeptide
Leishmania braziliensis LbrM.34.1630   casein kinase II, putative
Leishmania donovani LdBPK_351720.1   casein kinase II, putative
Leishmania infantum LinJ.35.1720   casein kinase II, putative
Leishmania major LmjF.35.1730   casein kinase II, putative
Leishmania mexicana LmxM.34.1730   casein kinase II, putative
Loa Loa (eye worm) LOAG_03081   CMGC/CK2 protein kinase
Mus musculus ENSMUSG00000046707   casein kinase 2, alpha prime polypeptide
Mus musculus ENSMUSG00000074698   casein kinase 2, alpha 1 polypeptide
Neospora caninum NCLIV_024840   hypothetical protein
Oryza sativa 9271280   Os03g0762000
Oryza sativa 4332003   Os03g0207300
Oryza sativa 4342248   Os07g0114400
Plasmodium berghei PBANKA_0938600   casein kinase 2, alpha subunit
Plasmodium falciparum PF3D7_1108400   casein kinase 2, alpha subunit
Plasmodium knowlesi PKNH_0906000   casein kinase 2, alpha subunit, putative
Plasmodium vivax PVX_091095   casein kinase 2, alpha subunit, putative
Plasmodium vivax PVX_252300   unspecified product
Plasmodium yoelii PY05048   Protein kinase domain
Saccharomyces cerevisiae YIL035C   casein kinase 2 catalytic subunit CKA1
Saccharomyces cerevisiae YOR061W   casein kinase 2 catalytic subunit CKA2
Schistosoma japonicum Sjp_0036170   ko:K03097 casein kinase 2, alpha polypeptide, putative
Schistosoma mansoni Smp_099030   protein kinase
Schmidtea mediterranea mk4.000166.08   Casein kinase II subunit alpha
Schmidtea mediterranea mk4.000424.04   Casein kinase II subunit alpha
Trypanosoma brucei gambiense Tbg972.9.9070   casein kinase II, putative
Trypanosoma brucei Tb927.9.14430   Casein kinase II
Trypanosoma congolense TcIL3000_0_32020   casein kinase II, putative
Trypanosoma cruzi TcCLB.510761.60   casein kinase II, putative
Toxoplasma gondii TGME49_263070   CMGC kinase, CK2 family
Theileria parva TP04_0659   casein kinase II, alpha chain
Trichomonas vaginalis TVAG_305130   CMGC family protein kinase
Trichomonas vaginalis TVAG_544210   CMGC family protein kinase
Trichomonas vaginalis TVAG_485710   CMGC family protein kinase
Trichomonas vaginalis TVAG_064190   CMGC family protein kinase
Trichomonas vaginalis TVAG_172040   CMGC family protein kinase
Trichomonas vaginalis TVAG_340780   CMGC family protein kinase
Trichomonas vaginalis TVAG_135230   CMGC family protein kinase

Essentiality

Chro.60083 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.4890 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.4890 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.4890 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.4890 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0205.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0205.7 Caenorhabditis elegans slow growth wormbase
CELE_B0205.7 Caenorhabditis elegans sterile wormbase
PBANKA_0938600 Plasmodium berghei Essential plasmo
TGME49_263070 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens casein kinase 2, alpha 3 polypeptide Compounds References
Mus musculus casein kinase 2, alpha prime polypeptide Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha Compounds References
Zea mays Casein kinase II alpha Compounds References
Homo sapiens casein kinase 2, alpha prime polypeptide Compounds References
Homo sapiens casein kinase 2, alpha 1 polypeptide Compounds References
Mus musculus casein kinase 2, alpha 1 polypeptide Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Chro.60083 (Cryptosporidium hominis), protein kinase domain
Title for this comment
Comment