Detailed view for Chro.10373

Basic information

TDR Targets ID: 363548
Cryptosporidium hominis, hypothetical protein
Source Database / ID: 

pI: 6.6055 | Length (AA): 174 | MW (Da): 20620 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00134   Cyclin, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 174 1jkw (A) 11 172 28.00 0.000000000018 0.47 1.19069 -0.2
14 171 1jkw (A) 11 169 32.00 0 0.63 1.18705 -0.12
56 170 1zp2 (A) 23 143 18.00 0 0.92 0.91972 -0.63
61 170 1c9b (A) 111 216 12.00 0 0.46 0.829984 -0.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129254)

Species Accession Gene Product
Arabidopsis thaliana AT5G27620   1
Brugia malayi Bm1_13860   Cyclin, N-terminal domain containing protein
Candida albicans CaO19.4542   cyclin
Candida albicans CaO19.12017   cyclin
Caenorhabditis elegans CELE_Y49F6B.1   Protein CYH-1
Cryptosporidium hominis Chro.10373   hypothetical protein
Cryptosporidium parvum cgd1_3310   cyclin domain protein, possible cyclin H
Dictyostelium discoideum DDB_G0292082   hypothetical protein
Dictyostelium discoideum DDB_G0268668   hypothetical protein
Drosophila melanogaster Dmel_CG7405   Cyclin H
Entamoeba histolytica EHI_054710   hypothetical protein
Homo sapiens ENSG00000134480   cyclin H
Loa Loa (eye worm) LOAG_03272   cyclin domain-containing protein
Mus musculus ENSMUSG00000021548   cyclin H
Oryza sativa 4334040   Os03g0737600
Saccharomyces cerevisiae YPR025C   TFIIH complex kinase subunit CCL1
Trichomonas vaginalis TVAG_062000   cyclin H, putative

Essentiality

Chro.10373 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y49F6B.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y49F6B.1 Caenorhabditis elegans larval arrest wormbase
CELE_Y49F6B.1 Caenorhabditis elegans slow growth wormbase
YPR025C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cyclin H Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Chro.10373 (Cryptosporidium hominis), hypothetical protein
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