pI: 6.5134 |
Length (AA): 220 |
MW (Da): 25120 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 153 | 1e69 (A) | 1 | 144 | 32.00 | 0 | 1 | 0.94 | -0.45 |
2 | 167 | 1xew (X) | 3 | 167 | 35.00 | 0 | 1 | 1.03 | 0.05 |
2 | 167 | 1xew (X) | 3 | 167 | 38.00 | 0.000000002 | 1 | 1.08 | -0.09 |
1 | 219 | 3auy (A) | 3 | 849 | 28.00 | 0.000071 | 1 | 1.07125 | 0.46 |
2 | 220 | 4ux3 (A) | 2 | 223 | 47.00 | 0 | 1 | 1.38825 | 0.69 |
2 | 219 | 5xns (A) | 3 | 989 | 34.00 | 0 | 1 | 1.42171 | -0.39 |
153 | 213 | 2fxo (A) | 897 | 963 | 39.00 | 0.11 | 0.12 | 0.685073 | -1.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | epimastigote. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127789)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G27170 | structural maintenance of chromosome 3 |
Babesia bovis | BBOV_III002920 | RecF/RecN/SMC N terminal domain containing protein |
Brugia malayi | Bm1_41400 | SMC proteins Flexible Hinge Domain containing protein |
Candida albicans | CaO19.7895 | potential SMC chromosomal ATPase similar to S. cerevisiae SMC3 (YJL074C) nuclear cohesin complex ATPase |
Caenorhabditis elegans | CELE_Y47D3A.26 | Protein SMC-3, isoform C |
Cryptosporidium parvum | cgd7_2700 | SMC3SMC type chromosomal ABC ATpase |
Dictyostelium discoideum | DDB_G0276101 | structural maintenance of chromosome protein |
Drosophila melanogaster | Dmel_CG9802 | Chromosome-associated protein |
Echinococcus granulosus | EgrG_001062500 | structural maintenance of chromosomes protein 3 |
Entamoeba histolytica | EHI_164820 | hypothetical protein |
Echinococcus multilocularis | EmuJ_001062500 | structural maintenance of chromosomes protein 3 |
Giardia lamblia | GL50803_137745 | SMC3-like protein |
Homo sapiens | ENSG00000108055 | structural maintenance of chromosomes 3 |
Leishmania braziliensis | LbrM.08.0010 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania donovani | LdBPK_080010.1 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania infantum | LinJ.08.0010 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania major | LmjF.08.0010 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Leishmania mexicana | LmxM.08.0010 | adaptor complex protein (AP) 3 delta subunit 1, putative |
Loa Loa (eye worm) | LOAG_02559 | SMC protein Flexible Hinge Domain containing protein |
Mus musculus | ENSMUSG00000024974 | structural maintenance of chromosomes 3 |
Neospora caninum | NCLIV_044540 | structural maintenance of chromosome domain- containing protein, putative |
Oryza sativa | 4328210 | Os02g0133300 |
Oryza sativa | 9269307 | Os02g0133400 |
Plasmodium berghei | PBANKA_0716000 | structural maintenance of chromosomes protein 3, putative |
Plasmodium falciparum | PF3D7_0414000 | structural maintenance of chromosomes protein 3, putative |
Plasmodium knowlesi | PKNH_0505600 | structural maintenance of chromosomes protein 3, putative |
Plasmodium vivax | PVX_089660 | chromosome associated protein, putative |
Plasmodium yoelii | PY00549 | chromosome-associated polypeptide, putative |
Saccharomyces cerevisiae | YJL074C | cohesin subunit SMC3 |
Schistosoma japonicum | Sjp_0311170 | Structural maintenance of chromosomes protein 3, putative |
Schistosoma japonicum | Sjp_0007580 | ko:K06669 structural maintenance of chromosome 3 (chondroitin sulfate, putative |
Schistosoma mansoni | Smp_134850 | Rootletin (Ciliary rootlet coiled-coil protein) |
Schistosoma mansoni | Smp_145260 | structural maintenance of chromosomes smc3 |
Schmidtea mediterranea | mk4.032314.00 | Structural maintenance of chromosomes protein 3 |
Schmidtea mediterranea | mk4.002068.00 | Structural maintenance of chromosomes protein 3 |
Trypanosoma brucei gambiense | Tbg972.5.4900 | structural maintenance of chromosome 3 , putative |
Trypanosoma brucei | Tb927.5.3510 | structural maintenance of chromosome 3 , putative |
Trypanosoma congolense | TcIL3000_0_18230 | structural maintenance of chromosome 3 , putative |
Trypanosoma congolense | TcIL3000_0_00320 | structural maintenance of chromosome 3 , putative |
Trypanosoma cruzi | TcCLB.503531.49 | structural maintenance of chromosome 3, putative |
Trypanosoma cruzi | TcCLB.511649.70 | structural maintenance of chromosome 3 protein, putative |
Toxoplasma gondii | TGME49_306310 | RecF/RecN/SMC N terminal domain-containing protein |
Theileria parva | TP03_0311 | hypothetical protein |
Trichomonas vaginalis | TVAG_333960 | cohesin subunit Smc3 |
Trichomonas vaginalis | TVAG_340870 | cohesin subunit Smc3 |
Trichomonas vaginalis | TVAG_193240 | cohesin subunit Smc3 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3510 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3510 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y47D3A.26 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_Y47D3A.26 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y47D3A.26 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y47D3A.26 | Caenorhabditis elegans | sterile | wormbase |
YJL074C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0716000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_306310 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.