Detailed view for Chro.80544

Basic information

TDR Targets ID: 363845
Cryptosporidium hominis, proteinx0005
Source Database / ID: 

pI: 9.4275 | Length (AA): 194 | MW (Da): 22894 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01648   4'-phosphopantetheinyl transferase superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0008897   holo-[acyl-carrier-protein] synthase activity  
GO:0000287   magnesium ion binding  

Metabolic Pathways

Pantothenate and CoA biosynthesis (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 187 2c43 (A) 63 243 22.00 0 0.73 1.15902 0.51
2 62 1f7l (A) 43 109 18.00 0.00011 0.74 0.491533 -0.2
4 177 2c43 (A) 66 233 33.00 0.000000000036 1 1.15581 0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129301)

Species Accession Gene Product
Arabidopsis thaliana AT2G02770   4'-phosphopantetheinyl transferase domain-containing protein
Arabidopsis thaliana AT3G11470   4'-phosphopantetheinyl transferase superfamily
Brugia malayi Bm1_31065   aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Caenorhabditis elegans CELE_T28H10.1   Protein T28H10.1
Caenorhabditis elegans CELE_T04G9.4   Protein T04G9.4
Cryptosporidium hominis Chro.80544   proteinx0005
Cryptosporidium parvum cgd8_4740   phosphopantetheinyl transferase
Dictyostelium discoideum DDB_G0285927   aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Drosophila melanogaster Dmel_CG32099   ebony activating protein
Echinococcus granulosus EgrG_001025600   L aminoadipate semialdehyde
Echinococcus multilocularis EmuJ_001025600   L aminoadipate semialdehyde
Homo sapiens ENSG00000149313   aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Loa Loa (eye worm) LOAG_05557   hypothetical protein
Mus musculus ENSMUSG00000025894   aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Oryza sativa 4351429   Os12g0133400
Oryza sativa 4349713   Os11g0136500
Oryza sativa 4345046   Os08g0243100
Onchocerca volvulus OVOC3813  
Schistosoma japonicum Sjp_0202010   expressed protein
Schistosoma japonicum Sjp_0011480   ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative
Schistosoma mansoni Smp_063390   aminoadipate-semialdehyde dehydrogenase
Schmidtea mediterranea mk4.032135.00  
Schmidtea mediterranea mk4.004835.03   L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Essentiality

Chro.80544 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T04G9.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_T04G9.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Chro.80544 (Cryptosporidium hominis), proteinx0005
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