Detailed view for Chro.80394

Basic information

TDR Targets ID: 364337
Cryptosporidium hominis, hypothetical protein
Source Database / ID: 

pI: 5.1262 | Length (AA): 324 | MW (Da): 36983 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06325   Ribosomal protein L11 methyltransferase (PrmA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0006479   protein amino acid methylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 318 5dx1 (A) 143 455 34.00 0 1 1.41048 -0.54
5 321 1g6q (1) 21 329 38.00 0 1 1.4589 -0.47
5 291 1g6q (1) 21 300 46.00 0 1 1.4173 -0.28
16 318 3q7e (A) 44 336 39.00 0 1 1.44719 -0.79
30 74 3ccf (A) 26 69 34.00 0 0.8 0.484889 0.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134380)

Species Accession Gene Product
Arabidopsis thaliana AT3G20020   protein arginine N-methyltransferase 6
Cryptosporidium hominis Chro.80394   hypothetical protein
Cryptosporidium parvum cgd8_3420   hypothetical protein
Dictyostelium discoideum DDB_G0276237   hypothetical protein
Homo sapiens ENSG00000198890   protein arginine methyltransferase 6
Mus musculus ENSMUSG00000049300   protein arginine N-methyltransferase 6
Oryza sativa 9268644   Os04g0677066
Oryza sativa 4348964   Os10g0489100
Schmidtea mediterranea mk4.019775.00   Protein arginine N-methyltransferase 6
Schmidtea mediterranea mk4.017465.00   Protein arginine N-methyltransferase 6

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein arginine methyltransferase 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Chro.80394 (Cryptosporidium hominis), hypothetical protein
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