Detailed view for TcCLB.503521.89

Basic information

TDR Targets ID: 36586
Trypanosoma cruzi, gpi mannosyltransferase 2
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.2704 | Length (AA): 529 | MW (Da): 60472 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04188   Mannosyltransferase (PIG-V)

Gene Ontology

Mouse over links to read term descriptions.
GO:0004584   dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity  
GO:0016021   integral to membrane  
GO:0005789   endoplasmic reticulum membrane  
GO:0006506   GPI anchor biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
206 371 1fft (C) 27 202 11.00 0 0 0.37 -0.53
28 264 4he8 (N) 171 405 13.00 0.19 0.06 0.497315 -0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128414)

Species Accession Gene Product
Arabidopsis thaliana AT1G11880   transferases, transferring hexosyl groups
Babesia bovis BBOV_IV007380   conserved hypothetical protein
Brugia malayi Bm1_48915   hypothetical protein
Candida albicans CaO19.8665   similar to S. cerevisiae mitochondrial protein Fmp44p (YBR004C) and to S. pombe SPAC18B11.05
Candida albicans CaO19.1063   similar to S. cerevisiae mitochondrial protein Fmp44p (YBR004C) and to S. pombe SPAC18B11.05
Caenorhabditis elegans CELE_T09B4.1   Protein T09B4.1
Cryptosporidium hominis Chro.60588   multi-pass transmembrane protein
Cryptosporidium parvum cgd6_5100   multi-pass transmembrane protein, putative
Dictyostelium discoideum DDB_G0280891   phosphatidylinositol glycan, class V
Drosophila melanogaster Dmel_CG44239   Phosphatidylinositol glycan anchor biosynthesis, class V ortholog (H. sapiens)
Echinococcus granulosus EgrG_001023900   gpi mannosyltransferase 2
Entamoeba histolytica EHI_068330   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001023900   gpi mannosyltransferase 2
Giardia lamblia GL50803_12174   Hypothetical protein
Homo sapiens ENSG00000060642   phosphatidylinositol glycan anchor biosynthesis, class V
Leishmania braziliensis LbrM.18.1010   mannosyltransferase-II, putative
Leishmania donovani LdBPK_180960.1   mannosyltransferase-II, putative
Leishmania infantum LinJ.18.0960   mannosyltransferase-II, putative
Leishmania major LmjF.18.0960   mannosyltransferase-II, putative
Leishmania mexicana LmxM.18.0960   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_15131   hypothetical protein
Loa Loa (eye worm) LOAG_10750   hypothetical protein
Mus musculus 230801   phosphatidylinositol glycan anchor biosynthesis, class V
Oryza sativa 4352265   Os12g0498700
Onchocerca volvulus OVOC903   GPI mannosyltransferase 2 homolog
Plasmodium berghei PBANKA_1460300   GPI mannosyltransferase 2, putative
Plasmodium falciparum PF3D7_1247300   GPI mannosyltransferase 2, putative
Plasmodium knowlesi PKNH_1467000   GPI mannosyltransferase 2, putative
Plasmodium vivax PVX_101257   GPI mannosyltransferase 2, putative
Saccharomyces cerevisiae YBR004C   Gpi18p
Schistosoma japonicum Sjp_0209170   ko:K07542 phosphatidylinositol glycan, class V, putative
Schistosoma mansoni Smp_177040   hypothetical protein
Schmidtea mediterranea mk4.005807.02   GPI mannosyltransferase 2
Schmidtea mediterranea mk4.003736.03   GPI mannosyltransferase 2
Trypanosoma brucei gambiense Tbg972.10.15910   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.13160   gpi mannosyltransferase 2
Trypanosoma brucei Tb11.v5.0437   Mannosyltransferase (PIG-V)), putative
Trypanosoma congolense TcIL3000_10_11250   mannosyltransferase-II, putative
Trypanosoma congolense TcIL3000_10_11240   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503521.89   gpi mannosyltransferase 2
Theileria parva TP03_0245   hypothetical protein

Essentiality

TcCLB.503521.89 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13160 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13160 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.13160 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T09B4.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T09B4.1 Caenorhabditis elegans larval arrest wormbase
CELE_T09B4.1 Caenorhabditis elegans sterile wormbase
YBR004C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1460300 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TcCLB.503521.89 (Trypanosoma cruzi), gpi mannosyltransferase 2
Title for this comment
Comment