Detailed view for PF3D7_0316800

Basic information

TDR Targets ID: 3665
Plasmodium falciparum, 40S ribosomal protein S15A, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.623 | Length (AA): 130 | MW (Da): 14874 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00410   Ribosomal protein S8

Gene Ontology

Mouse over links to read term descriptions.
GO:0022627   cytosolic small ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 130 1i6u (A) 2 130 43.00 0 1 1.6 -2.02
2 130 4kzy (W) 2 130 73.00 0 1 1.92851 -1.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3JBN:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3JBP:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_126878)

Species Accession Gene Product
Arabidopsis thaliana AT3G46040   40S ribosomal protein S15a-4
Arabidopsis thaliana AT5G59850   40S ribosomal protein S15a-1
Arabidopsis thaliana AT1G07770   40S ribosomal protein S15a-1
Arabidopsis thaliana AT2G39590   40S ribosomal protein S15a-3
Babesia bovis BBOV_III010810   ribosomal protein S8 family protein
Brugia malayi Bm1_48545   40S ribosomal protein S15a
Candida albicans CaO19.6265   likely cytosolic ribosomal protein similar to S. cerevisiae RPS22A (YJL190C) and RPS22B (YLR367W) small subunit protein S22
Candida albicans CaO19.13644   likely cytosolic ribosomal protein similar to S. cerevisiae RPS22A (YJL190C) and RPS22B (YLR367W) small subunit protein S22
Caenorhabditis elegans CELE_F53A3.3   Protein RPS-22, isoform B
Cryptosporidium hominis Chro.80500   ribosomal protein S8
Cryptosporidium parvum cgd8_4360   40S ribosomal protein S15A
Dictyostelium discoideum DDB_G0276457   40S ribosomal protein S15a
Drosophila melanogaster Dmel_CG2033   Ribosomal protein S15Aa
Drosophila melanogaster Dmel_CG12324   Ribosomal protein S15Ab
Echinococcus granulosus EgrG_000955400   ribosomal protein S15Aa
Entamoeba histolytica EHI_073600   40S ribosomal protein S15a, putative
Entamoeba histolytica EHI_167270   40S ribosomal protein S15a, putative
Entamoeba histolytica EHI_105140   40S ribosomal protein S15a, putative
Echinococcus multilocularis EmuJ_000955400   ribosomal protein S15Aa
Giardia lamblia GL50803_15228   Ribosomal protein S15A
Homo sapiens ENSG00000134419   ribosomal protein S15a
Leishmania braziliensis LbrM.11.0990   40S ribosomal protein S15A, putative
Leishmania braziliensis LbrM.31.0190   40S ribosomal protein S15a
Leishmania donovani LdBPK_291920.1   40S ribosomal protein S15A, putative
Leishmania donovani LdBPK_111180.1   40S ribosomal protein S15A, putative
Leishmania infantum LinJ.29.1920   40S ribosomal protein S15A, putative
Leishmania infantum LinJ.11.1180   40S ribosomal protein S15A, putative
Leishmania major LmjF.29.1800   40S ribosomal protein S15A, putative
Leishmania major LmjF.11.1190   40S ribosomal protein S15A, putative
Leishmania mexicana LmxM.11.1190   40S ribosomal protein S15A, putative
Leishmania mexicana LmxM.08_29.1800   40S ribosomal protein S15A, putative
Loa Loa (eye worm) LOAG_03447   ribosomal protein rps15a
Mus musculus ensembl-mmu:ENSMUSG00000008683   ribosomal protein S15A
Neospora caninum NCLIV_049600   30S ribosomal protein S8P, related
Oryza sativa 4329361   Os02g0478600
Oryza sativa 4342697   Os07g0208000
Plasmodium berghei PBANKA_0414600   40S ribosomal protein S15A, putative
Plasmodium falciparum PF3D7_0316800   40S ribosomal protein S15A, putative
Plasmodium knowlesi PKNH_0825000   40S ribosomal protein S15A, putative
Plasmodium vivax PVX_095390   40S ribosomal protein S15Aa, putative
Plasmodium yoelii PY04951   ribosomal protein S8
Saccharomyces cerevisiae YLR367W   ribosomal 40S subunit protein S22B
Saccharomyces cerevisiae YJL190C   ribosomal 40S subunit protein S22A
Schistosoma japonicum Sjp_0217780   ko:K02957 small subunit ribosomal protein S15Ae, putative
Schistosoma mansoni Smp_076740   30S ribosomal protein S8
Schmidtea mediterranea mk4.000065.25   40S ribosomal protein S15a
Trypanosoma brucei gambiense Tbg972.11.6920   40S ribosomal protein S15A, putative
Trypanosoma brucei gambiense Tbg972.3.4760   40S ribosomal protein S15A, putative
Trypanosoma brucei Tb927.3.4360   40S ribosomal protein S15A, putative
Trypanosoma brucei Tb927.11.6140   40S ribosomal protein S15A, putative
Trypanosoma cruzi TcCLB.506297.330   40S ribosomal protein S15A, putative
Trypanosoma cruzi TcCLB.508041.30   40S ribosomal protein S15A, putative
Trypanosoma cruzi TcCLB.509381.20   40S ribosomal protein S15A, putative
Toxoplasma gondii TGME49_234450   ribosomal protein RPS15A
Theileria parva TP02_0064   40S ribosomal protein S15a, putative
Trichomonas vaginalis TVAG_462530   30S ribosomal protein S8, putative
Trichomonas vaginalis TVAG_164700   30S ribosomal protein S8, putative
Trichomonas vaginalis TVAG_006250   30S ribosomal protein S8, putative

Essentiality

PF3D7_0316800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.4000 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.4000 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.4000 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.4000 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F53A3.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F53A3.3 Caenorhabditis elegans larval arrest wormbase
CELE_F53A3.3 Caenorhabditis elegans slow growth wormbase
TGME49_234450 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0316800 (Plasmodium falciparum), 40S ribosomal protein S15A, putative
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