pI: 9.8798 |
Length (AA): 374 |
MW (Da): 43083 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
118 | 237 | 1win (A) | 10 | 138 | 22.00 | 0.000000037 | 0.95 | 0.67 | -1.17 |
118 | 284 | 3bk6 (A) | 63 | 224 | 35.00 | 0.0019 | 1 | 0.903124 | -0.42 |
127 | 225 | 4fvg (A) | 103 | 201 | 36.00 | 0.00000000011 | 1 | 0.878706 | -1.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, early trophozoite, Ring, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | late trophozoite, Female Gametocyte, Male Gametocyte. | PlasmoDB Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_126714)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G27585 | SPFH/Band 7/PHB domain-containing membrane-associated protein |
Arabidopsis thaliana | AT5G54100 | SPFH/Band 7/PHB domain-containing membrane-associated protein |
Babesia bovis | BBOV_I003370 | stomatin-like protein, putative |
Brugia malayi | Bm1_19615 | Mechanosensory protein 2 |
Brugia malayi | Bm1_16790 | SD03319p |
Candida albicans | CaO19.4079 | potential SPFH domain, similar to mouse somatostatin-like protein SLP2 |
Candida albicans | CaO19.11560 | potential SPFH domain, similar to mouse somatostatin-like protein SLP2 |
Candida albicans | CaO19.7296 | similar to fungal and archaebacterial somatostatin-like proteins |
Caenorhabditis elegans | CELE_F32A6.5 | Protein STO-2, isoform A |
Caenorhabditis elegans | CELE_F08C6.4 | Protein STO-1, isoform A |
Caenorhabditis elegans | CELE_F30A10.5 | Protein STL-1, isoform A |
Caenorhabditis elegans | CELE_F14D12.4 | Protein MEC-2, isoform C |
Dictyostelium discoideum | DDB_G0274345 | hypothetical protein |
Dictyostelium discoideum | DDB_G0290995 | hypothetical protein |
Dictyostelium discoideum | DDB_G0270694 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7635 | CG7635 gene product from transcript CG7635-RA |
Drosophila melanogaster | Dmel_CG33253 | CG33253 gene product from transcript CG33253-RA |
Drosophila melanogaster | Dmel_CG2970 | CG2970 gene product from transcript CG2970-RA |
Drosophila melanogaster | Dmel_CG42540 | CG42540 gene product from transcript CG42540-RB |
Escherichia coli | b0489 | PHB domain membrane-anchored putative protease |
Echinococcus granulosus | EgrG_000450500 | MEChanosensory abnormality family member |
Echinococcus granulosus | EgrG_000194700 | stomatin |
Echinococcus granulosus | EgrG_000764700 | mechanosensory protein 2 |
Echinococcus granulosus | EgrG_000469900 | mechanosensory protein 2 |
Echinococcus granulosus | EgrG_000951400 | stomatin protein 2 |
Echinococcus multilocularis | EmuJ_000194700 | stomatin |
Echinococcus multilocularis | EmuJ_000469900 | mechanosensory protein 2 |
Echinococcus multilocularis | EmuJ_000450500 | MEChanosensory abnormality family member |
Echinococcus multilocularis | EmuJ_000764700 | mechanosensory protein 2 |
Echinococcus multilocularis | EmuJ_000951400 | stomatin protein 2 |
Homo sapiens | ENSG00000165283 | stomatin (EPB72)-like 2 |
Homo sapiens | ENSG00000148175 | stomatin |
Homo sapiens | ENSG00000133115 | stomatin (EPB72)-like 3 |
Leishmania braziliensis | LbrM.05.1040 | stomatin-like protein |
Leishmania donovani | LdBPK_051040.1 | stomatin-like protein |
Leishmania infantum | LinJ.05.1040 | stomatin-like protein |
Leishmania major | LmjF.05.1040 | stomatin-like protein |
Leishmania mexicana | LmxM.05.1040 | stomatin-like protein |
Loa Loa (eye worm) | LOAG_06519 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07695 | stomatin-like protein 2 |
Loa Loa (eye worm) | LOAG_03876 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08946 | mechanosensory protein 2 |
Mycobacterium leprae | ML1802c | POSSIBLE EXPORTED CONSERVED PROTEIN |
Mus musculus | 229277 | stomatin (Epb7.2)-like 3 |
Mus musculus | ENSMUSG00000028455 | stomatin (Epb7.2)-like 2 |
Mus musculus | ENSMUSG00000026880 | stomatin |
Mycobacterium tuberculosis | Rv1488 | Possible exported conserved protein |
Neospora caninum | NCLIV_005610 | Membrane protein, related |
Oryza sativa | 4344707 | Os08g0158500 |
Onchocerca volvulus | OVOC1865 | Mechanosensory protein 2 homolog |
Onchocerca volvulus | OVOC2280 |
|
Plasmodium berghei | PBANKA_0807100 | stomatin-like protein |
Plasmodium falciparum | PF3D7_0318100 | stomatin-like protein |
Plasmodium knowlesi | PKNH_0823700 | stomatin-like protein |
Plasmodium vivax | PVX_095325 | stomatin-like protein |
Plasmodium yoelii | PY03188 | SPFH domain / Band 7 family, putative |
Schistosoma japonicum | Sjp_0030930 | Erythrocyte band 7 integral membrane protein, putative |
Schistosoma japonicum | Sjp_0056460 | Mechanosensory protein 2, putative |
Schistosoma japonicum | Sjp_0066860 | Mechanosensory protein 2, putative |
Schistosoma japonicum | Sjp_0302870 | Stomatin-like protein 2, putative |
Schistosoma mansoni | Smp_122810 | stomatin-related |
Schistosoma mansoni | Smp_066520 | stomatin-related |
Schistosoma mansoni | Smp_072640 | stomatin-related |
Schmidtea mediterranea | mk4.024732.00 | Stomatin-2 |
Schmidtea mediterranea | mk4.014996.00 | SPFH domain / Band 7 family protein,putative |
Schmidtea mediterranea | mk4.022912.00 | |
Schmidtea mediterranea | mk4.006318.00 | SPFH domain / Band 7 family protein,putative |
Schmidtea mediterranea | mk4.000339.01 | SPFH domain / Band 7 family protein,putative |
Schmidtea mediterranea | mk4.000241.00 | Stomatin-like protein 2, mitochondrial |
Schmidtea mediterranea | mk4.011666.00 | |
Schmidtea mediterranea | mk4.007362.00 | Podocin |
Schmidtea mediterranea | mk4.021161.00 | SPFH domain / Band 7 family protein,putative |
Schmidtea mediterranea | mk4.012803.00 | |
Schmidtea mediterranea | mk4.005777.00 | SPFH domain / Band 7 family protein,putative |
Schmidtea mediterranea | mk4.014634.00 | |
Schmidtea mediterranea | mk4.006350.02 | Stomatin-3 |
Schmidtea mediterranea | mk4.016769.01 | Stomatin-2 |
Schmidtea mediterranea | mk4.002400.02 | SPFH domain / Band 7 family protein,putative |
Trypanosoma brucei gambiense | Tbg972.5.540 | stomatin-like protein, putative |
Trypanosoma brucei | Tb927.5.520 | stomatin-like protein, putative |
Trypanosoma congolense | TcIL3000_5_200 | stomatin-like protein, putative |
Trypanosoma cruzi | TcCLB.508397.30 | SPFH domain / Band 7 family protein, putative |
Trypanosoma cruzi | TcCLB.509885.30 | SPFH domain / Band 7 family protein, putative |
Toxoplasma gondii | TGME49_222210 | SPFH domain / Band 7 family protein |
Theileria parva | TP03_0186 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.520 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.520 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.520 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.5.520 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0489 | Escherichia coli | non-essential | goodall |
CELE_F30A10.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F30A10.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F30A10.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F30A10.5 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0807100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_222210 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.