pI: 5.7455 |
Length (AA): 567 |
MW (Da): 61547 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 557 | 4b2t (a) | 1005 | 1533 | 61.00 | 0 | 1 | 0.889054 | 2.17 |
10 | 557 | 4b2t (A) | 6 | 533 | 61.00 | 0 | 1 | 1.51559 | -0.03 |
215 | 374 | 1ass (A) | 1 | 152 | 37.00 | 0 | 1 | 0.780987 | -1.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127998)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G20050 | T-complex protein 1 subunit alpha |
Babesia bovis | BBOV_I003340 | t-complex protein 1, alpha subunit, putative |
Brugia malayi | Bm1_43680 | T-complex protein 1, alpha subunit |
Candida albicans | CaO19.401 | similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Candida albicans | CaO19.8031 | similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Caenorhabditis elegans | CELE_T05C12.7 | Protein CCT-1 |
Cryptosporidium hominis | Chro.20068 | t-complex protein 1, alpha subunit |
Cryptosporidium parvum | cgd2_600 | t-complex protein 1, alpha subunit |
Chlamydia trachomatis | CT_604 | chaperonin GroEL |
Dictyostelium discoideum | DDB_G0269190 | chaperonin containing TCP1 alpha subunit |
Drosophila melanogaster | Dmel_CG5374 | Tcp1-like |
Echinococcus granulosus | EgrG_000826700 | T complex protein 1 subunit alpha |
Entamoeba histolytica | EHI_155220 | T-complex protein 1, alpha subunit, putative |
Echinococcus multilocularis | EmuJ_000826700 | T complex protein 1 subunit alpha |
Giardia lamblia | GL50803_91919 | TCP-1 chaperonin subunit alpha |
Homo sapiens | ENSG00000120438 | t-complex 1 |
Leishmania braziliensis | LbrM.32.3560 | chaperonin alpha subunit, putative |
Leishmania donovani | LdBPK_323470.1 | chaperonin alpha subunit, putative |
Leishmania infantum | LinJ.32.3470 | chaperonin alpha subunit, putative |
Leishmania major | LmjF.32.3270 | chaperonin alpha subunit, putative |
Leishmania mexicana | LmxM.31.3270 | chaperonin alpha subunit, putative |
Loa Loa (eye worm) | LOAG_03598 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03164 | T-complex protein 1 |
Mus musculus | ENSMUSG00000068039 | t-complex protein 1 |
Neospora caninum | NCLIV_030660 | TCP-1/cpn60 family chaperonin, putative |
Oryza sativa | 4336600 | Os04g0551800 |
Plasmodium berghei | PBANKA_0916200 | T-complex protein 1 subunit alpha, putative |
Plasmodium falciparum | PF3D7_1132200 | T-complex protein 1 subunit alpha |
Plasmodium knowlesi | PKNH_0930400 | T-complex protein 1 subunit alpha, putative |
Plasmodium vivax | PVX_092215 | T-complex protein 1 subunit alpha, putative |
Plasmodium yoelii | PY03629 | t-complex protein 1, alpha subunit |
Saccharomyces cerevisiae | YDR212W | chaperonin-containing T-complex alpha subunit TCP1 |
Schistosoma japonicum | Sjp_0082530 | ko:K09493 T-complex protein 1 subunit alpha, putative |
Schistosoma mansoni | Smp_017360 | T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) |
Schmidtea mediterranea | mk4.003845.01 | T-complex protein 1 subunit alpha |
Schmidtea mediterranea | mk4.002735.04 | T-complex protein 1 subunit alpha |
Schmidtea mediterranea | mk4.017724.00 | T-complex protein 1 subunit alpha |
Schmidtea mediterranea | mk4.004933.01 | T-complex protein 1 subunit alpha |
Schmidtea mediterranea | mk4.004933.00 | T-complex protein 1 subunit alpha |
Trypanosoma brucei gambiense | Tbg972.11.18900 | T-complex protein 1, alpha subunit, putative |
Trypanosoma brucei | Tb427tmp.01.8510 | T-complex protein 1, alpha subunit, putative |
Trypanosoma brucei | Tb927.11.16760 | T-complex protein 1, alpha subunit, putative |
Trypanosoma congolense | TcIL3000.11.16670 | T-complex protein 1, alpha subunit, putative |
Trypanosoma cruzi | TcCLB.511531.40 | chaperonin alpha subunit, putative |
Trypanosoma cruzi | TcCLB.511025.70 | chaperonin alpha subunit, putative |
Toxoplasma gondii | TGME49_229990 | T-complex protein 1 subunit alpha, putative |
Theileria parva | TP03_0183 | T-complex protein 1, alpha subunit , putative |
Trichomonas vaginalis | TVAG_364270 | chaperonin containing t-complex protein 1, beta subunit, tcpb, putative |
Trichomonas vaginalis | TVAG_350510 | chaperonin containing t-complex protein 1, eta subunit, tcph, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.8510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.8510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.8510 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.8510 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T05C12.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05C12.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T05C12.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T05C12.7 | Caenorhabditis elegans | sterile | wormbase |
YDR212W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_229990 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaaca fascicularis | T-complex protein 1 subunit beta | 535 aa | 33.1% | 544 aa | Compounds | References |