Detailed view for TcCLB.503721.30

Basic information

TDR Targets ID: 38210
Trypanosoma cruzi, conserved protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0261 | Length (AA): 1715 | MW (Da): 189115 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12738   twin BRCT domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 15 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1352 1493 2etx (A) 1912 2037 19.00 0.0000042 1 0.15 0.75
2 96 1l7b (A) 7 75 29.00 0 0.66 -0.0595064 0.69
3 96 3pd7 (A) 905 975 21.00 0 0.71 -0.11209 -0.04
3 96 2d8m (A) 23 90 29.00 0 1 0.0369105 0.06
3 96 2cou (A) 13 80 19.00 0 0.33 -0.13109 0.07
37 97 2ebu (A) 416 477 18.00 0 0.81 0.262669 -0.04
44 184 3olc (X) 121 280 21.00 0 0.78 0.234816 -0.18
129 248 3wad (A) 184 295 34.00 0.85 0.04 0.0561708 2.1
1087 1206 2co7 (B) 28 145 30.00 0.46 0.34 0.192171 0.44
1322 1426 3ii6 (X) 656 759 14.00 0.36 0.13 0.196824 -0.26
1325 1547 4igk (A) 1647 1851 13.00 0 0.99 0.0976292 0.48
1330 1559 1gzh (D) 1734 1970 18.00 0 0.14 0.0917108 0.73
1331 1432 2d8m (A) 29 128 12.00 0.00031 0.18 0.118075 0.16
1356 1539 3l41 (A) 690 861 15.00 0 0.81 0.258389 -0.12
1365 1481 3al2 (A) 1307 1422 30.00 0.036 0.78 0.246422 0.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_148732)

Species Accession Gene Product
Leishmania braziliensis LbrM.26.1250   hypothetical protein, conserved
Leishmania donovani LdBPK_261210.1   hypothetical protein, conserved
Leishmania infantum LinJ.26.1210   hypothetical protein, conserved
Leishmania major LmjF.26.1230   hypothetical protein, conserved
Leishmania mexicana LmxM.26.1230   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.7.650   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.720   conserved protein
Trypanosoma congolense TcIL3000_0_55920   conserved protein
Trypanosoma cruzi TcCLB.506135.20   conserved protein
Trypanosoma cruzi TcCLB.503721.30   conserved protein

Essentiality

TcCLB.503721.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.720 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.720 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.720 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.720 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.503721.30 (Trypanosoma cruzi), conserved protein
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