pI: 7.1003 |
Length (AA): 1010 |
MW (Da): 120659 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
697 | 1002 | 1zdz (A) | 17 | 285 | 16.00 | 0 | 0.42 | 0.39 | -0.99 |
702 | 1007 | 1iy9 (A) | 5 | 274 | 17.00 | 0 | 0.99 | 0.3 | -0.76 |
54 | 179 | 3ccf (A) | 24 | 143 | 10.00 | 0.2 | 0.11 | 0.167952 | 0.06 |
487 | 923 | 3hvd (C) | 271 | 721 | 22.00 | 0.96 | 1 | 0.394173 | 1.56 |
716 | 919 | 2hte (B) | 21 | 215 | 30.00 | 0.5 | 0.96 | 0.17448 | 1.11 |
765 | 999 | 3gjy (A) | 59 | 280 | 14.00 | 0.0000000014 | 0.88 | 0.357873 | -0.79 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, sporozoite, early ring, early trophozoite, late ring, late trophozoite. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, gametocyte, merozoite, early schizont, Ring, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 48 hs, Oocyst, Female Gametocyte, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127173)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G60910 | S-adenosyl-L-methionine-dependent methyltransferase-like protein |
Arabidopsis thaliana | AT2G31740 | S-adenosylmethionine-dependent methyltransferase domain-containing protein |
Arabidopsis thaliana | AT4G34360 | S-adenosyl-L-methionine-dependent methyltransferase-like protein |
Arabidopsis thaliana | AT3G17365 | S-adenosyl-L-methionine-dependent methyltransferase-like protein |
Babesia bovis | BBOV_IV005270 | membrane protein, putative |
Babesia bovis | BBOV_II003780 | hypothetical protein |
Brugia malayi | Bm1_00410 | hypothetical protein |
Brugia malayi | Bm1_54620 | Spermine/spermidine synthase family protein |
Caenorhabditis elegans | CELE_C17E4.11 | Protein C17E4.11 |
Caenorhabditis elegans | CELE_C01B10.8 | Protein C01B10.8 |
Cryptosporidium hominis | Chro.30168 | P0700D12.13 |
Cryptosporidium hominis | Chro.60327 | CG2614 protein |
Cryptosporidium parvum | cgd6_2820 | 2 SAM dependent methyltransferase; S-adenosyl-L-methionine-dependent methyltransferases + spermidine synthase (SAM dependent met |
Cryptosporidium parvum | cgd3_1360 | methylase |
Dictyostelium discoideum | DDB_G0280123 | hypothetical protein |
Dictyostelium discoideum | DDB_G0282393 | hypothetical protein |
Drosophila melanogaster | Dmel_CG2614 | CG2614 gene product from transcript CG2614-RA |
Echinococcus granulosus | EgrG_000121700 | methyltransferase protein 13 |
Entamoeba histolytica | EHI_092620 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000121700 | methyltransferase protein 13 |
Giardia lamblia | GL50803_4349 | Endothelin-converting enzyme 2 |
Homo sapiens | ENSG00000010165 | methyltransferase like 13 |
Leishmania braziliensis | LbrM.05.1100 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_051100.1 | methyltransferase domain containing protein, putative |
Leishmania infantum | LinJ.05.1100 | hypothetical protein, conserved |
Leishmania major | LmjF.05.1100 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.05.1100 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_13262 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11489 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12643 | hypothetical protein |
Mus musculus | ENSMUSG00000022842 | endothelin converting enzyme 2 |
Mus musculus | 71449 | methyltransferase like 13 |
Neospora caninum | NCLIV_005320 | hypothetical protein |
Neospora caninum | NCLIV_054190 | hypothetical protein |
Neospora caninum | NCLIV_013470 | Spermine/spermidine synthase family protein, related |
Oryza sativa | 4350724 | Os11g0557700 |
Oryza sativa | 4346041 | Os08g0517600 |
Oryza sativa | 4335621 | Os04g0379300 |
Onchocerca volvulus | OVOC3395 |
|
Plasmodium berghei | PBANKA_1006900 | conserved Plasmodium protein, unknown function |
Plasmodium berghei | PBANKA_1318900 | methyltransferase, putative |
Plasmodium falciparum | PF3D7_0409300 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_1455200 | methyltransferase, putative, unspecified product |
Plasmodium knowlesi | PKNH_1226800 | methyltransferase, putative |
Plasmodium knowlesi | PKNH_0307400 | S-adenosyl-L-methionine-dependent methyltransferase, putative |
Plasmodium vivax | PVX_000780 | hypothetical protein, conserved |
Plasmodium yoelii | PY04095 | hypothetical protein |
Plasmodium yoelii | PY00864 | unknown protein-related |
Schmidtea mediterranea | mk4.000217.15 | |
Trypanosoma brucei gambiense | Tbg972.7.8060 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.6890 | methyltransferase domain containing protein, putative |
Trypanosoma congolense | TcIL3000_7_5550 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508389.10 | methyltransferase domain containing protein, putative |
Trypanosoma cruzi | TcCLB.506789.120 | methyltransferase domain containing protein, putative |
Toxoplasma gondii | TGME49_213740 | hypothetical protein |
Toxoplasma gondii | TGME49_310070 | methyltransferase, putative |
Toxoplasma gondii | TGME49_221818 | hypothetical protein |
Theileria parva | TP01_0211 | hypothetical protein |
Theileria parva | TP04_0198 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_365940 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_093950 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_376050 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_TEG_DS113583_1_26 | Maverick transposable element conserved hypothetical protein |
Trichomonas vaginalis | TVAG_309010 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_081710 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_255110 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_040100 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.6890 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.6890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.6890 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.6890 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C17E4.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_1006900 | Plasmodium berghei | Dispensable | plasmo |
TGME49_213740 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_221818 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_310070 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_213740 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_221818 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_310070 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.