pI: 10.5484 |
Length (AA): 194 |
MW (Da): 23407 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
72 | 143 | 2rsm (A) | 41 | 109 | 42.00 | 0.00000073 | 0.99 | 0.849734 | -0.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | sporozoite, late schizont, Sporozoite. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, early trophozoite, late trophozoite, Oocyst, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Ring, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 8 hs. | Otto TD |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_129206)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV005260 | conserved hypothetical protein |
Brugia malayi | Bm1_08890 | hypothetical protein |
Candida albicans | CaO19.5488 | similar to S. cerevisiae YLR281C |
Candida albicans | CaO19.12943 | similar to S. cerevisiae YLR281C |
Caenorhabditis elegans | CELE_T23B5.4 | Protein T23B5.4, isoform B |
Drosophila melanogaster | Dmel_CG30100 | CG30100 gene product from transcript CG30100-RA |
Echinococcus granulosus | EgrG_000185900 | peptide chain release factor corf |
Echinococcus multilocularis | EmuJ_000185900 | peptide chain release factor corf mitochondrial polypeptide chain release factor |
Homo sapiens | ENSG00000130921 | chromosome 12 open reading frame 65 |
Leishmania braziliensis | LbrM.30.3570 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_303600.1 | RF-1 domain containing protein, putative |
Leishmania infantum | LinJ.30.3600 | hypothetical protein, conserved |
Leishmania major | LmjF.30.3540 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.29.3540 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_08838 | hypothetical protein |
Mus musculus | ENSMUSG00000047635 | RIKEN cDNA 2810006K23 gene |
Onchocerca volvulus | OVOC3962 | Putative peptide chain release factor C12orf65, mitochondrial |
Plasmodium berghei | PBANKA_1007300 | peptide chain release factor 2, putative |
Plasmodium falciparum | PF3D7_0409700 | peptide chain release factor 2 |
Plasmodium knowlesi | PKNH_0307800 | peptide chain release factor 2, putative |
Plasmodium vivax | PVX_000760 | hypothetical protein, conserved |
Plasmodium yoelii | PY04089 | hypothetical protein |
Saccharomyces cerevisiae | YLR281C | hypothetical protein |
Schistosoma japonicum | Sjp_0213390 | similar to Uncharacterized protein C12orf65, putative |
Schistosoma mansoni | Smp_079810 | hypothetical protein |
Schmidtea mediterranea | mk4.000724.04 | Probable peptide chain release factor C12orf65, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.6.4740 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.4940 | RF-1 domain containing protein, putative |
Trypanosoma congolense | TcIL3000_6_4360 | RF-1 domain containing protein, putative |
Trypanosoma cruzi | TcCLB.506945.180 | RF-1 domain containing protein, putative |
Toxoplasma gondii | TGME49_206360 | peptidyl-tRNA hydrolase domain-containing protein |
Theileria parva | TP01_0213 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4940 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4940 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4940 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.6.4940 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1007300 | Plasmodium berghei | Dispensable | plasmo |
TGME49_206360 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.