pI: 9.4177 |
Length (AA): 575 |
MW (Da): 68533 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
328 | 571 | 4u0r (A) | 179 | 488 | 22.00 | 0.0039 | 0.17 | 0.538848 | -0.19 |
394 | 570 | 4wat (A) | 225 | 454 | 31.00 | 0.89 | 0.08 | 0.221726 | 0.85 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Sporozoite. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 32 hs, merozoite, sporozoite, early ring, early trophozoite, late ring, late schizont, Ring, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | early schizont, late trophozoite, Male Gametocyte. | PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | gametocyte. | PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127615)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G24500 | zinc finger domain protein REI1-LIKE 2 |
Arabidopsis thaliana | AT4G31420 | protein REI1-LIKE 1 |
Babesia bovis | BBOV_III010450 | hypothetical protein |
Brugia malayi | Bm1_41325 | Zinc finger, C2H2 type family protein |
Candida albicans | CaO19.59 | potential Zn finger orf similar to S. cerevisiae YBR267W |
Candida albicans | CaO19.7720 | potential Zn finger orf similar to S. cerevisiae YBR267W |
Candida albicans | CaO19.6407 | potential zinc finger protein similar to S. cerevisiae YLR387C |
Candida albicans | CaO19.13765 | potential zinc finger protein similar to S. cerevisiae YLR387C |
Caenorhabditis elegans | CELE_C16A3.4 | Protein C16A3.4 |
Cryptosporidium hominis | Chro.80183 | hypothetical protein |
Cryptosporidium parvum | cgd8_1550 | S. cerevisiae YLR387c-like protein with 2x C2H2 like zinc fingers conserved across eukaryotes plus an apicomplexan-specific glob |
Dictyostelium discoideum | DDB_G0290029 | C2H2-type zinc finger-containing protein |
Drosophila melanogaster | Dmel_CG6769 | CG6769 gene product from transcript CG6769-RB |
Echinococcus granulosus | EgrG_000377550 | zinc finger protein 622 |
Entamoeba histolytica | EHI_154230 | zinc finger protein 622, putative |
Echinococcus multilocularis | EmuJ_000377550 | zinc finger protein 622 |
Giardia lamblia | GL50803_13007 | Zinc finger domain |
Homo sapiens | ENSG00000173545 | zinc finger protein 622 |
Leishmania braziliensis | LbrM.30.2200 | zinc-finger protein, conserved |
Leishmania donovani | LdBPK_302260.1 | zinc-finger protein, conserved |
Leishmania infantum | LinJ.30.2260 | zinc-finger protein, conserved |
Leishmania major | LmjF.30.2250 | zinc-finger protein, conserved |
Leishmania mexicana | LmxM.29.2250 | zinc-finger protein, conserved |
Loa Loa (eye worm) | LOAG_08093 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09469 | zinc finger protein |
Mus musculus | ENSMUSG00000052253 | zinc finger protein 622 |
Neospora caninum | NCLIV_068940 | hypothetical protein |
Oryza sativa | 4341920 | Os06g0693500 |
Onchocerca volvulus | OVOC8723 | Zinc finger protein 622 homolog |
Plasmodium berghei | PBANKA_1007400 | zinc finger protein, putative |
Plasmodium falciparum | PF3D7_0409800 | zinc finger protein, putative |
Plasmodium knowlesi | PKNH_0307900 | zinc finger protein, putative |
Plasmodium vivax | PVX_000755 | zinc finger protein, putative |
Plasmodium yoelii | PY04088 | hypothetical protein |
Saccharomyces cerevisiae | YLR387C | Reh1p |
Saccharomyces cerevisiae | YBR267W | Rei1p |
Schistosoma japonicum | Sjp_0103440 | Zinc finger protein 622, putative |
Schistosoma mansoni | Smp_163430 | hypothetical protein |
Schmidtea mediterranea | mk4.009222.01 | |
Trypanosoma brucei gambiense | Tbg972.6.3300 | zinc-finger protein, conserved |
Trypanosoma brucei | Tb927.6.3540 | zinc-finger protein, conserved |
Trypanosoma congolense | TcIL3000_6_3120 | zinc-finger protein, conserved, putative |
Trypanosoma cruzi | TcCLB.506941.50 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511511.50 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_239070 | hypothetical protein |
Theileria parva | TP02_0101 | hypothetical protein |
Trichomonas vaginalis | TVAG_388070 | 45.8 kD protein in shm1-mrpl37 intergenic region, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.3540 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3540 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.3540 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C16A3.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C16A3.4 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_239070 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.