Detailed view for PF3D7_0410300

Basic information

TDR Targets ID: 3879
Plasmodium falciparum, protein phosphatase PPM1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.9461 | Length (AA): 906 | MW (Da): 105199 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00481   Protein phosphatase 2C

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0004721   phosphoprotein phosphatase activity  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 15 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
554 905 1a6q () 6 329 26.00 0 1 0.41 -0.22
615 870 1a6q () 36 296 32.00 0 1 0.69 -0.87
27 466 2vkh (A) 46 425 28.00 0.35 1 0.406451 1.56
202 398 2qkw (B) 57 251 11.00 0.02 0.03 0.00403929 1.03
239 398 4u5a (A) 48 231 18.00 0.3 0.04 0.3329 -0.66
427 542 1k28 (A) 428 544 33.00 0.054 0.04 0.156835 1.22
563 870 3rt0 (A) 182 506 24.00 0 1 0.397256 0.19
612 815 2irm (A) 44 287 27.00 0.014 0.87 0.225966 1.13
626 862 4yzg (A) 78 345 33.00 0 1 0.526389 -0.38
631 865 2iq1 (A) 117 346 35.00 0 1 0.624182 -0.48
715 903 3d8k (A) 242 429 25.00 0.0011 0.96 0.348909 0.92
564 871 3rt0 (A) 182 506 24.00 0 1 0.433781 -0.18
602 868 3nmv (B) 113 413 24.00 0 1 0.602577 -0.72
609 882 4rag (A) 27 307 27.00 0 1 0.608295 -0.4
627 863 4yzg (A) 78 345 33.00 0 1 0.525701 -0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Oocyst, Ring, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Female Gametocyte. Otto TD Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_149969)

Species Accession Gene Product
Arabidopsis thaliana AT1G48040   putative protein phosphatase 2C 13
Arabidopsis thaliana AT3G17250   putative protein phosphatase 2C 43
Arabidopsis thaliana AT3G62260   putative protein phosphatase 2C 49
Oryza sativa 4326717   Os01g0295700
Oryza sativa 4337723   Os05g0134200
Plasmodium falciparum PF3D7_0410300   protein phosphatase PPM1, putative
Plasmodium knowlesi PKNH_0308400   protein phosphatase PPM1, putative
Plasmodium vivax PVX_000735   protein phosphatase PPM1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Calcineurin (3.1.3.16 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

25 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0410300 (Plasmodium falciparum), protein phosphatase PPM1, putative
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