pI: 7.3782 |
Length (AA): 392 |
MW (Da): 44666 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 389 | 1e32 (A) | 44 | 454 | 30.00 | 0 | 1 | 1.28 | -0.03 |
130 | 377 | 1ixz (A) | 148 | 393 | 42.00 | 0 | 1 | 1.26 | -1.79 |
1 | 390 | 3cf3 (A) | 344 | 758 | 31.00 | 0.049 | 1 | 1.2912 | 0.31 |
127 | 384 | 3h4m (A) | 159 | 416 | 57.00 | 0.000023 | 1 | 1.44736 | -1.33 |
310 | 381 | 3aji (B) | 337 | 408 | 60.00 | 0 | 1 | 1.02567 | -1.49 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Sporozoite, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Male Gametocyte. | PlasmoDB Lasonder E |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127831)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G58290 | regulatory particle triple-A ATPase 3 |
Babesia bovis | BBOV_II004930 | 26s proteasome aaa-ATPase subunit Rpt3, putative |
Brugia malayi | Bm1_46680 | 26S proteasome subunit P45 family protein |
Candida albicans | CaO19.13215 | likely ATPase similar to S. cerevisiae RPT3 (YDR394W) ATPase subunit of the 19S regulatory particle of the 26S proteasome |
Candida albicans | CaO19.5793 | likely ATPase similar to S. cerevisiae RPT3 (YDR394W) ATPase subunit of the 19S regulatory particle of the 26S proteasome |
Caenorhabditis elegans | CELE_F23F12.6 | Protein RPT-3 |
Cryptosporidium hominis | Chro.40284 | 26S proteasome AAA-ATPase subunit RPT3 |
Cryptosporidium parvum | cgd4_2540 | 26S proteasome regulatory subunit 26b like AAA ATpase |
Dictyostelium discoideum | DDB_G0289003 | 26S protease regulatory subunit 6B |
Drosophila melanogaster | Dmel_CG16916 | Regulatory particle triple-A ATPase 3 |
Drosophila melanogaster | Dmel_CG9475 | Regulatory particle triple-A ATPase 3-related |
Echinococcus granulosus | EgrG_000223000 | 26S proteasome regulatory subunit T3 |
Entamoeba histolytica | EHI_177320 | 26S protease regulatory subunit, putative |
Echinococcus multilocularis | EmuJ_000223000 | 26S proteasome regulatory subunit T3 |
Giardia lamblia | GL50803_7950 | 26S protease regulatory subunit 6B |
Homo sapiens | ENSG00000013275 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 |
Leishmania braziliensis | LbrM.12.0230 | proteasome regulatory ATPase subunittcc1l8.3, putative |
Leishmania donovani | LdBPK_120190.1 | proteasome regulatory ATPase subunittcc1l8.3, putative |
Leishmania infantum | LinJ.12.0190 | proteasome regulatory ATPase subunittcc1l8.3, putative |
Leishmania major | LmjF.12.0210 | proteasome regulatory ATPase subunittcc1l8.3, putative |
Leishmania mexicana | LmxM.12.0210 | proteasome regulatory ATPase subunittcc1l8.3, putative |
Loa Loa (eye worm) | LOAG_02032 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02033 | hypothetical protein |
Mus musculus | ENSMUSG00000030603 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 |
Neospora caninum | NCLIV_030650 | 26S protease regulatory subunit 6b, putative |
Oryza sativa | 4329182 | Os02g0325100 |
Onchocerca volvulus | OVOC9841 |
|
Onchocerca volvulus | OVOC9840 |
|
Plasmodium berghei | PBANKA_0715600 | 26S protease regulatory subunit 6B, putative |
Plasmodium falciparum | PF3D7_0413600 | 26S protease regulatory subunit 6B, putative |
Plasmodium knowlesi | PKNH_0505200 | 26S protease regulatory subunit 6B, putative |
Plasmodium vivax | PVX_089640 | 26S proteasome AAA-ATPase subunit RPT3, putative |
Plasmodium yoelii | PY00544 | 26S proteasome ATPase |
Saccharomyces cerevisiae | YDR394W | proteasome regulatory particle base subunit RPT3 |
Schistosoma japonicum | Sjp_0044260 | ko:K03063 26S proteasome regulatory subunit T3, putative |
Schistosoma mansoni | Smp_072340 | 26S protease regulatory subunit 6b |
Schmidtea mediterranea | mk4.001221.01 | Probable 26S protease regulatory subunit 6B |
Schmidtea mediterranea | mk4.011994.00 | Probable 26S protease regulatory subunit 6B |
Schmidtea mediterranea | mk4.036310.00 | Probable 26S protease regulatory subunit 6B |
Schmidtea mediterranea | mk4.012227.01 | Probable 26S protease regulatory subunit 6B |
Schmidtea mediterranea | mk4.001192.11 | Probable 26S protease regulatory subunit 6B |
Schmidtea mediterranea | mk4.001674.04 | Probable 26S protease regulatory subunit 6B |
Schmidtea mediterranea | mk4.037323.01 | Probable 26S protease regulatory subunit 6B |
Schmidtea mediterranea | mk4.002262.02 | |
Schmidtea mediterranea | mk4.001406.00 | Probable 26S protease regulatory subunit 6B |
Trypanosoma brucei gambiense | Tbg972.6.790 | proteasome regulatory ATPase subunit 3, putative |
Trypanosoma brucei | Tb927.6.1090 | proteasome regulatory ATPase subunit 3 |
Trypanosoma congolense | TcIL3000_6_560 | proteasome regulatory ATPase subunit 3, putative |
Trypanosoma congolense | TcIL3000_0_16770 | proteasome regulatory ATPase subunit 3 |
Trypanosoma cruzi | TcCLB.509429.270 | proteasome regulatory ATPase subunit 3, putative |
Trypanosoma cruzi | TcCLB.507603.200 | proteasome regulatory ATPase subunit 3, putative |
Toxoplasma gondii | TGME49_229950 | 26S proteasome regulatory subunit 6b, putative |
Theileria parva | TP04_0031 | 26S proteasome aaa-ATPase subunit Rpt3, putative |
Trichomonas vaginalis | TVAG_433230 | 26S protease regulatory subunit, putative |
Trichomonas vaginalis | TVAG_135700 | 26S protease regulatory subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.1090 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.1090 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.1090 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.1090 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F23F12.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F23F12.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F23F12.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F23F12.6 | Caenorhabditis elegans | sterile | wormbase |
YDR394W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0715600 | Plasmodium berghei | Slow | plasmo |
TGME49_229950 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | Compounds | References |