pI: 9.6274 |
Length (AA): 112 |
MW (Da): 13208 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 16 hs, Oocyst, Ring, Sporozoite, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, Male Gametocyte. | Otto TD Lasonder E |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_130486)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G29020 | Rab5-interacting-like protein |
Arabidopsis thaliana | AT5G59410 | Rab5-interacting family protein |
Brugia malayi | Bm1_21665 | rab5-interacting protein |
Caenorhabditis elegans | CELE_F44E7.9 | Protein F44E7.9 |
Cryptosporidium parvum | cgd1_1770 | putative Rab5-interacting protein |
Dictyostelium discoideum | DDB_G0289011 | hypothetical protein |
Drosophila melanogaster | Dmel_CG12107 | CG12107 gene product from transcript CG12107-RA |
Echinococcus granulosus | EgrG_000075100 | Rab5 interacting |
Echinococcus granulosus | EgrG_000075200 | peptidyl prolyl cis trans isomerase FKBP5 |
Entamoeba histolytica | EHI_196950 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000075100 | Rab5 interacting |
Homo sapiens | ENSG00000101084 | chromosome 20 open reading frame 24 |
Homo sapiens | ENSG00000259399 | TGIF2-C20orf24 readthrough |
Loa Loa (eye worm) | LOAG_11502 | rab5-interacting protein |
Mus musculus | ENSMUSG00000027637 | RIKEN cDNA 1110008F13 gene |
Neospora caninum | NCLIV_005490 | hypothetical protein, conserved |
Oryza sativa | 4337590 | Os05g0110600 |
Onchocerca volvulus | OVOC5865 |
|
Plasmodium berghei | PBANKA_0716300 | Rab5-interacting protein, putative |
Plasmodium falciparum | PF3D7_0414300 | Rab5-interacting protein, putative |
Plasmodium knowlesi | PKNH_0505900 | Rab5-interacting protein, putative |
Plasmodium vivax | PVX_089670 | Rab5-interacting protein, putative |
Schistosoma japonicum | Sjp_0205750 | IPR013105,Tetratricopeptide TPR_2,domain-containing |
Schistosoma japonicum | Sjp_0307510 | similar to Uncharacterized protein C20orf24, putative |
Schistosoma mansoni | Smp_160270 | hypothetical protein |
Schistosoma mansoni | Smp_160260 | hypothetical protein |
Schmidtea mediterranea | mk4.000056.23 | |
Toxoplasma gondii | TGME49_222090 | hypothetical protein |
Trichomonas vaginalis | TVAG_402250 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0716300 | Plasmodium berghei | Dispensable | plasmo |
TGME49_222090 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.