Detailed view for TcCLB.506363.60

Basic information

TDR Targets ID: 39258
Trypanosoma cruzi, f-actin capping protein beta subunit, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.1669 | Length (AA): 485 | MW (Da): 54901 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00397   WW domain
PF01115   F-actin capping protein, beta subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0051016   barbed-end actin filament capping  
GO:0008290   F-actin capping protein complex  
GO:0005737   cytoplasm  
GO:0005515   protein binding  
GO:0003779   actin binding  
GO:0030036   actin cytoskeleton organization and biogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 311 1izn (B) 2 260 29.00 0 0.98 0.69 0.3
370 398 1zr7 (A) 10 38 48.00 0.0000019 0.97 0.75 -1.4
423 455 1wr7 (A) 9 41 9.00 0.000000023 0.02 0.23 -0.95
14 308 1izn (B) 8 257 31.00 0 1 0.781547 0.4
358 397 1wr4 (A) 3 34 37.00 0 0.41 0.316774 -0.9
366 397 1e0l (A) 2 33 50.00 0.0014 0.6 0.617479 0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128870)

Species Accession Gene Product
Arabidopsis thaliana AT1G71790   probable F-actin-capping protein subunit beta
Brugia malayi Bm1_47000   F-actin capping protein beta subunit
Candida albicans CaO19.12066   F-actin capping protein beta subunit
Candida albicans CaO19.4597   F-actin capping protein beta subunit
Caenorhabditis elegans CELE_M106.5   Protein CAP-2
Dictyostelium discoideum DDB_G0267374   subunit of heterodimeric actin capping protein cap32/34
Drosophila melanogaster Dmel_CG17158   capping protein beta
Echinococcus granulosus EgrG_000772300   F actin capping protein subunit beta
Echinococcus granulosus EgrG_000257920   F actin capping protein subunit beta
Entamoeba histolytica EHI_005020   F-actin capping protein beta subunit, putative
Echinococcus multilocularis EmuJ_000257920   F actin capping protein, beta subunit
Echinococcus multilocularis EmuJ_000772300   F actin capping protein subunit beta
Homo sapiens ENSG00000077549   capping protein (actin filament) muscle Z-line, beta
Loa Loa (eye worm) LOAG_04611   F-actin capping protein beta subunit
Mus musculus ENSMUSG00000028745   capping protein (actin filament) muscle Z-line, beta
Neospora caninum NCLIV_061190   f-actin capping protein beta subunit, putative
Oryza sativa 4332978   Os03g0381200
Plasmodium berghei PBANKA_1232400   F-actin-capping protein subunit beta
Plasmodium falciparum PF3D7_0517600   F-actin-capping protein subunit beta, putative
Plasmodium knowlesi PKNH_1015700   F-actin-capping protein subunit beta, putative
Plasmodium vivax PVX_080370   F-actin-capping protein subunit beta, putative
Plasmodium yoelii PY03888   F-actin capping protein, beta subunit
Saccharomyces cerevisiae YIL034C   F-actin-capping protein subunit beta
Schistosoma japonicum Sjp_0005140   ko:K10365 capping protein (actin filament) muscle Z-line, beta, putative
Schistosoma mansoni Smp_186650   f-actin capping protein beta subunit
Schmidtea mediterranea mk4.001101.02   F-actin-capping protein subunit beta
Trypanosoma cruzi TcCLB.506363.60   f-actin capping protein beta subunit, putative
Trypanosoma cruzi TcCLB.506975.49   f-actin capping protein beta subunit, putative
Toxoplasma gondii TGME49_219290   F-actin-capping protein subunit beta, putative
Trichomonas vaginalis TVAG_398750   f-actin capping protein beta subunit, putative
Trichomonas vaginalis TVAG_261590   f-actin capping protein beta subunit, putative
Trichomonas vaginalis TVAG_271840   f-actin capping protein beta subunit, putative
Trichomonas vaginalis TVAG_094060   f-actin capping protein beta subunit, putative
Trichomonas vaginalis TVAG_396060   f-actin capping protein beta subunit, putative

Essentiality

TcCLB.506363.60 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_M106.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_M106.5 Caenorhabditis elegans larval arrest wormbase
CELE_M106.5 Caenorhabditis elegans larval lethal wormbase
CELE_M106.5 Caenorhabditis elegans slow growth wormbase
CELE_M106.5 Caenorhabditis elegans sterile wormbase
PBANKA_1232400 Plasmodium berghei Dispensable plasmo
TGME49_219290 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.506363.60 (Trypanosoma cruzi), f-actin capping protein beta subunit, putative
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