Detailed view for TcCLB.506979.50

Basic information

TDR Targets ID: 39360
Trypanosoma cruzi, UNC119
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.7622 | Length (AA): 196 | MW (Da): 23097 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05351   GMP-PDE, delta subunit

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 187 1ksh (B) 14 149 29.00 0 0.69 0.9 -0.81
40 149 1ksh (B) 22 120 41.00 0.0000000023 0.71 0.78 0.55
4 189 3gqq (B) 57 238 51.00 0 1 1.56728 -0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_129841)

Species Accession Gene Product
Brugia malayi Bm1_16980   hypothetical protein
Caenorhabditis elegans CELE_M142.1   Protein UNC-119, isoform B
Drosophila melanogaster Dmel_CG1659   CG1659 gene product from transcript CG1659-RC
Giardia lamblia GL50803_27147   Hypothetical protein
Homo sapiens ENSG00000175970   unc-119 homolog B (C. elegans)
Homo sapiens ENSG00000109103   unc-119 homolog (C. elegans)
Leishmania braziliensis LbrM.27.2180   hypothetical protein, conserved
Leishmania donovani LdBPK_271920.1   GMP-PDE, delta subunit, putative
Leishmania infantum LinJ.27.1920   hypothetical protein, conserved
Leishmania major LmjF.27.2000   hypothetical protein, conserved
Leishmania mexicana LmxM.27.2000   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_12785   hypothetical protein
Mus musculus ENSMUSG00000002058   unc-119 homolog (C. elegans)
Mus musculus ENSMUSG00000046562   unc-119 homolog B (C. elegans)
Schmidtea mediterranea mk4.000457.07  
Trypanosoma brucei gambiense Tbg.972.2.2640   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.4580   UNC119
Trypanosoma congolense TcIL3000_2_920   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506979.50   UNC119
Trypanosoma cruzi TcCLB.503499.10   UNC119

Essentiality

TcCLB.506979.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.4580 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.4580 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.4580 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.4580 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506979.50 (Trypanosoma cruzi), UNC119
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