Detailed view for PF3D7_0419200

Basic information

TDR Targets ID: 3964
Plasmodium falciparum, protein transport protein GOT1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.2911 | Length (AA): 136 | MW (Da): 15890 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04178   Got1/Sft2-like family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016192   vesicle-mediated transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 33 4tlm (A) 798 827 23.00 0 0.01 -0.0850059 3.83
12 78 3rko (M) 118 194 33.00 0.07 0.04 0.348347 2.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, early schizont, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, gametocyte, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst. Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127881)

Species Accession Gene Product
Arabidopsis thaliana AT3G03180   Got1/Sft2-like vescicle transport protein
Arabidopsis thaliana AT5G01430   Got1/Sft2-like vescicle transport protein
Arabidopsis thaliana AT1G05785   Got1/Sft2-like vescicle transport protein
Arabidopsis thaliana AT3G49420   Got1/Sft2-like vescicle transport-like protein
Babesia bovis BBOV_II003950   CGI-141 protein-like protein, putative
Babesia bovis BBOV_II003960   membrane protein, putative
Brugia malayi Bm1_54185   UPF0198 protein CGI-141 homolog
Candida albicans CaO19.3972   Golgi transport
Candida albicans CaO19.11455   Golgi transport
Caenorhabditis elegans CELE_F41C3.4   Protein F41C3.4
Cryptosporidium hominis Chro.20025   CGI-141 protein
Cryptosporidium parvum cgd2_190   conserved hypothetical protein
Dictyostelium discoideum DDB_G0292868   golgi transport protein 1
Drosophila melanogaster Dmel_CG32576   CG32576 gene product from transcript CG32576-RB
Echinococcus granulosus EgrG_000999400   vesicle transport protein got1b
Entamoeba histolytica EHI_177450   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000999400   vesicle transport protein got1b
Homo sapiens ENSG00000111711   golgi transport 1B
Leishmania braziliensis LbrM.18.1650   hypothetical protein, conserved
Leishmania donovani LdBPK_181610.1   Got1/Sft2-like family, putative
Leishmania infantum LinJ.18.1610   hypothetical protein, conserved
Leishmania major LmjF.18.1620   hypothetical protein, conserved
Leishmania mexicana LmxM.18.1620   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_09368   hypothetical protein
Mus musculus ENSMUSG00000030245   golgi transport 1 homolog B (S. cerevisiae)
Neospora caninum NCLIV_002290   hypothetical protein
Oryza sativa 4329905   Os02g0602800
Oryza sativa 4343788   Os07g0593400
Oryza sativa 9271603   Os10g0337600
Oryza sativa 4332016   Os03g0209400
Onchocerca volvulus OVOC10905   Putative Golgi transport protein 1
Plasmodium berghei PBANKA_0721300   protein transport protein GOT1, putative
Plasmodium falciparum PF3D7_0419200   protein transport protein GOT1, putative
Plasmodium knowlesi PKNH_0511900   protein transport protein GOT1, putative
Plasmodium vivax PVX_090050   Got1 domain containing protein
Plasmodium yoelii PY07464   hypothetical protein
Saccharomyces cerevisiae YMR292W   Got1p
Schistosoma japonicum Sjp_0083930   Vesicle transport protein GOT1B, putative
Schistosoma mansoni Smp_166120   hypothetical protein
Schmidtea mediterranea mk4.002413.01   Probable Golgi transport protein 1
Trypanosoma brucei gambiense Tbg972.10.14960   predicted S. cerevisiae Got1 homologue
Trypanosoma brucei Tb927.10.12420   predicted S. cerevisiae Got1 homologue
Trypanosoma congolense TcIL3000_10_10640   predicted to be involved in ER-Golgi transport, putative
Trypanosoma cruzi TcCLB.507787.30   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507625.160   hypothetical protein, conserved
Toxoplasma gondii TGME49_295460   Got1 family protein
Theileria parva TP04_0155   hypothetical protein
Trichomonas vaginalis TVAG_375340   Vesicle transport protein GOT1B, putative
Trichomonas vaginalis TVAG_177460   conserved hypothetical protein
Trichomonas vaginalis TVAG_200610   Vesicle transport protein GOT1B, putative

Essentiality

PF3D7_0419200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.12420 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.12420 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.12420 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.12420 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F41C3.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_F41C3.4 Caenorhabditis elegans larval arrest wormbase
CELE_F41C3.4 Caenorhabditis elegans larval lethal wormbase
CELE_F41C3.4 Caenorhabditis elegans sterile wormbase
TGME49_295460 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0419200 (Plasmodium falciparum), protein transport protein GOT1, putative
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