Detailed view for TcCLB.509505.50

Basic information

TDR Targets ID: 39721
Trypanosoma cruzi, 10 kDa heat shock protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.7592 | Length (AA): 180 | MW (Da): 20098 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00166   Chaperonin 10 Kd subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0005524   ATP binding  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
88 179 1p3h (A) 1 98 34.00 0 0.98 0.84 -0.36
88 178 4pj1 (O) 5 100 42.00 0 1 0.926356 0.29
92 178 3nx6 (A) 3 94 42.00 0.00087 0.94 0.755133 0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126769)

Species Accession Gene Product
Arabidopsis thaliana AT1G14980   chaperonin 10
Arabidopsis thaliana AT5G20720   chaperonin 20
Arabidopsis thaliana AT1G23100   GroES-like protein
Babesia bovis BBOV_I004480   chaperonin, 10 kDa domain containing protein
Babesia bovis BBOV_III006630   chaperonin, 10 kDa family protein
Brugia malayi Bm1_56470   chaperonin-10 kDa
Caenorhabditis elegans CELE_Y22D7AL.10   Protein Y22D7AL.10
Cryptosporidium hominis Chro.70275   hypothetical protein
Cryptosporidium parvum cgd7_2400   chaperonin 10 Kd subunit, putative
Chlamydia trachomatis CT_111   co-chaperonin GroES
Dictyostelium discoideum DDB_G0287811   chaperonin 10
Dictyostelium discoideum DDB_G0288265   chaperonin 10
Drosophila melanogaster Dmel_CG9920   CG9920 gene product from transcript CG9920-RA
Drosophila melanogaster Dmel_CG11267   CG11267 gene product from transcript CG11267-RA
Escherichia coli b4142   Cpn10 chaperonin GroES, small subunit of GroESL
Echinococcus granulosus EgrG_000320800   heat shock 10 kDa protein 1
Entamoeba histolytica EHI_188880   Chaperonin 10 Kd subunit, putative
Echinococcus multilocularis EmuJ_000320800   heat shock 10 kDa protein 1
Homo sapiens ENSG00000115541   heat shock 10kDa protein 1
Leishmania braziliensis LbrM.26.0630   10 kDa heat shock protein, putative
Leishmania braziliensis LbrM.26.0650   10 kDa heat shock protein, putative
Leishmania donovani LdBPK_260610.1   10 kDa heat shock protein, putative
Leishmania infantum LinJ.26.0610   10 kDa heat shock protein, putative
Leishmania infantum LinJ.26.0590   10 kDa heat shock protein, putative
Leishmania major LmjF.26.0620   10 kDa heat shock protein, putative
Leishmania major LmjF.26.0640   10 kDa heat shock protein, putative
Leishmania mexicana LmxM.26.0620   10 kDa heat shock protein, putative
Mycobacterium leprae ML0380   10 kD chaperonin GroES (Protein Cpn10) (groES protein) (BCG-A heat shock protein) (10 kDa antigen)
Mus musculus ENSMUSG00000073676   heat shock protein 1 (chaperonin 10)
Mus musculus 623924   predicted gene 6462
Mus musculus 102635299   predicted gene, 32676
Mycobacterium tuberculosis Rv3418c   10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen)
Mycobacterium ulcerans MUL_0885   co-chaperonin GroES
Neospora caninum NCLIV_033780   YALI0B05610p, related
Neospora caninum NCLIV_024410   10 kDa chaperonin, related
Oryza sativa 4347161   Os09g0438700
Oryza sativa 4344071   Os07g0641700
Oryza sativa 4332912   Os03g0366000
Oryza sativa 4330925   Os02g0781400
Oryza sativa 4340394   Os06g0196900
Onchocerca volvulus OVOC9330   10 kDa heat shock protein, mitochondrial homolog
Plasmodium berghei PBANKA_1347800   20 kDa chaperonin, putative
Plasmodium berghei PBANKA_1431050   10 kDa chaperonin, putative
Plasmodium falciparum PF3D7_1215300   10 kDa chaperonin
Plasmodium falciparum PF3D7_1333000   20 kDa chaperonin
Plasmodium knowlesi PKNH_1267600   20 kDa chaperonin, putative
Plasmodium knowlesi PKNH_1434800   10 kDa chaperonin, putative
Plasmodium vivax PVX_123450   10 kDa chaperonin, putative
Plasmodium vivax PVX_082580   20 kDa chaperonin, putative
Plasmodium yoelii PY01850   chaperonin, 10 kDa
Plasmodium yoelii PY02750   chaperonin, 10 kDa
Saccharomyces cerevisiae YOR020C   Hsp10p
Schistosoma japonicum Sjp_0307410   ko:K04078 chaperonin GroES, putative
Schistosoma mansoni Smp_097380   groes chaperonin
Schmidtea mediterranea mk4.000007.08   10 kDa heat shock protein, mitochondrial
Trypanosoma brucei gambiense Tbg972.7.1300   10 kDa heat shock protein, putative
Trypanosoma brucei gambiense Tbg972.7.1280   10 kDa heat shock protein, putative
Trypanosoma brucei Tb927.7.1320   10 kDa heat shock protein, putative
Trypanosoma brucei Tb927.7.1340   10 kDa heat shock protein, putative
Trypanosoma congolense TcIL3000_7_940   10 kDa heat shock protein, putative
Trypanosoma cruzi TcCLB.509505.70   10 kDa heat shock protein, putative
Trypanosoma cruzi TcCLB.509505.50   10 kDa heat shock protein, putative
Trypanosoma cruzi TcCLB.508209.90   10 kDa heat shock protein, putative
Trypanosoma cruzi TcCLB.508209.100   10 kDa heat shock protein, putative
Trypanosoma cruzi TcCLB.508209.120   10 kDa heat shock protein, putative
Trypanosoma cruzi TcCLB.509505.30   10 kDa heat shock protein, putative
Toxoplasma gondii TGME49_263530   chaperonin, putative
Toxoplasma gondii TGME49_273960   chaperonin GroS protein
Treponema pallidum TP1013   co-chaperonin GroES
Theileria parva TP02_0311   chaperonin 20 precursor, putative
Theileria parva TP01_0190   chaperonin 10 kDa, putative
Trichomonas vaginalis TVAG_392320   groes chaperonin, putative
Trichomonas vaginalis TVAG_445730   groes chaperonin, putative
Trichomonas vaginalis TVAG_041340   groes chaperonin, putative
Trichomonas vaginalis TVAG_191660   groes chaperonin, putative
Wolbachia endosymbiont of Brugia malayi Wbm0349   co-chaperonin GroES

Essentiality

TcCLB.509505.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.1320 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.1320 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.1320 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.1320 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b4142 Escherichia coli essential goodall
CELE_Y22D7AL.10 Caenorhabditis elegans embryonic lethal wormbase
YOR020C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1347800 Plasmodium berghei Essential plasmo
TGME49_273960 Toxoplasma gondii Probably essential sidik
TGME49_263530 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Reagent:
  • Target Type Source Notes
    TcCLB.509505.50 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Trypanosoma cruzi ( 1 )

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.509505.50 (Trypanosoma cruzi), 10 kDa heat shock protein, putative
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