Detailed view for TcCLB.506297.160

Basic information

TDR Targets ID: 39892
Trypanosoma cruzi, 40S ribosomal protein S5, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.943 | Length (AA): 190 | MW (Da): 21253 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00177   Ribosomal protein S7p/S5e

Gene Ontology

Mouse over links to read term descriptions.
GO:0015935   small ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003723   RNA binding  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 190 1iqv (A) 19 218 39.00 0 1 1.27 -0.48
48 189 1rss () 16 153 31.00 0 1 1.05 -0.71
6 190 4kzy (F) 17 204 69.00 0 1 1.78908 -0.41
96 187 5cwl (A) 74 169 20.00 0.11 0.16 0.765611 -1.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 5OPT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127064)

Species Accession Gene Product
Arabidopsis thaliana AT3G11940   40S ribosomal protein S5A
Arabidopsis thaliana AT2G37270   40S ribosomal protein S5-1
Babesia bovis BBOV_I000230   40S ribosomal protein S5, putative
Brugia malayi Bm1_27835   40S ribosomal protein S5
Candida albicans CaO19.11812   likely cytosolic ribosomal protein similar to S. cerevisiae RPS5 (YJR123W) small subunit protein S5
Candida albicans CaO19.4336   likely cytosolic ribosomal protein similar to S. cerevisiae RPS5 (YJR123W) small subunit protein S5
Caenorhabditis elegans CELE_T05E11.1   Protein RPS-5
Cryptosporidium hominis Chro.60495   ribosomal protein S5
Cryptosporidium parvum cgd6_4320   40S ribosomal protein S5
Dictyostelium discoideum DDB_G0286075   40S ribosomal protein S5
Drosophila melanogaster Dmel_CG8922   Ribosomal protein S5a
Drosophila melanogaster Dmel_CG7014   Ribosomal protein S5b
Echinococcus granulosus EgrG_000228600   ribosomal protein
Entamoeba histolytica EHI_126110   40S ribosomal protein S5
Entamoeba histolytica EHI_200850   40S ribosomal protein S5
Entamoeba histolytica EHI_137870   40S ribosomal protein S5
Entamoeba histolytica EHI_044590   40S ribosomal protein S5
Echinococcus multilocularis EmuJ_000228600   ribosomal protein
Giardia lamblia GL50803_12981   Ribosomal protein S5
Homo sapiens ENSG00000083845   ribosomal protein S5
Leishmania braziliensis LbrM.11.0760   40S ribosomal protein S5
Leishmania infantum LinJ.11.0960   40S ribosomal protein S5
Leishmania major LmjF.11.0960   40S ribosomal protein S5
Leishmania major LmjF.11.0970   40S ribosomal protein S5
Leishmania mexicana LmxM.11.0970   40S ribosomal protein S5
Leishmania mexicana LmxM.11.0960   40S ribosomal protein S5
Loa Loa (eye worm) LOAG_02133   40S ribosomal protein S5
Mus musculus ENSMUSG00000012848   ribosomal protein S5
Neospora caninum NCLIV_017500   hypothetical protein
Oryza sativa 4350516   Os11g0482000
Oryza sativa 4326457   Os01g0100700
Plasmodium berghei PBANKA_0619100   40S ribosomal protein S5, putative
Plasmodium falciparum PF3D7_0721600   40S ribosomal protein S5, putative
Plasmodium knowlesi PKNH_0317000   40S ribosomal protein S5, putative
Plasmodium vivax PVX_096265   40S ribosomal protein S5, putative
Plasmodium yoelii PY06068   ribosomal protein S7
Saccharomyces cerevisiae YJR123W   ribosomal 40S subunit protein S5
Schistosoma japonicum Sjp_0025220   ko:K02989 small subunit ribosomal protein S5e, putative
Schistosoma mansoni Smp_093440   40S ribosomal protein S5
Schmidtea mediterranea mk4.007539.00   40S ribosomal protein S5
Schmidtea mediterranea mk4.003201.00   40S ribosomal protein S5
Trypanosoma brucei gambiense Tbg972.11.7110   40S ribosomal protein S5, putative
Trypanosoma brucei gambiense Tbg972.11.7100   40S ribosomal protein S5, putative
Trypanosoma brucei Tb927.11.6300   40S ribosomal protein S5, putative
Trypanosoma congolense TcIL3000.11.6840   40S ribosomal protein S5, putative
Trypanosoma congolense TcIL3000.11.6850   40S ribosomal protein S5, putative
Trypanosoma congolense TcIL3000_0_41060   40S ribosomal protein S5, putative
Trypanosoma cruzi TcCLB.510101.170   40S ribosomal protein S5, putative
Trypanosoma cruzi TcCLB.510101.180   40S ribosomal protein S5, putative
Trypanosoma cruzi TcCLB.506297.150   40S ribosomal protein S5, putative
Trypanosoma cruzi TcCLB.506297.160   40S ribosomal protein S5, putative
Toxoplasma gondii TGME49_242330   ribosomal protein RPS5
Theileria parva TP03_0860   40S ribosomal protein S5, putative
Trichomonas vaginalis TVAG_163450   30S ribosomal protein S7p, putative
Trichomonas vaginalis TVAG_471390   40S ribosomal protein S5, putative
Trichomonas vaginalis TVAG_163210   40S ribosomal protein S5, putative
Trichomonas vaginalis TVAG_163440   40S ribosomal protein S5, putative
Trichomonas vaginalis TVAG_246200   ribosomal protein S7, putative
Trichomonas vaginalis TVAG_163180   40S ribosomal protein S5, putative

Essentiality

TcCLB.506297.160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.4170 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.4170 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.4170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.4170 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T05E11.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05E11.1 Caenorhabditis elegans larval arrest wormbase
CELE_T05E11.1 Caenorhabditis elegans slow growth wormbase
CELE_T05E11.1 Caenorhabditis elegans sterile wormbase
YJR123W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0619100 Plasmodium berghei Essential plasmo
TGME49_242330 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506297.160 (Trypanosoma cruzi), 40S ribosomal protein S5, putative
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