Detailed view for TcCLB.508851.150

Basic information

TDR Targets ID: 40037
Trypanosoma cruzi, CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.8475 | Length (AA): 349 | MW (Da): 38734 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02492   CobW/HypB/UreG, nucleotide-binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 224 2hf9 (A) 17 217 19.00 0 0.55 0.68 -0.79
16 344 1nij (A) 2 318 27.00 0 1 1.14 -0.62
18 339 1nij (A) 4 313 33.00 0 1 1.27 -0.66
1 116 4xc8 (A) 184 314 34.00 0.069 0.7 0.494878 0.41
12 217 2hf9 (A) 27 210 22.00 0 0.92 0.740158 -0.18
16 339 1nij (A) 2 313 24.00 0.000000025 0.96 1.20667 0.06
17 339 1nij (A) 3 313 29.00 0 1 1.1864 0

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127264)

Species Accession Gene Product
Arabidopsis thaliana AT1G26520   Cobalamin biosynthesis CobW-like protein
Arabidopsis thaliana AT1G80480   protein plastid transcriptionally active 17
Arabidopsis thaliana AT1G15730   Cobalamin biosynthesis CobW-like protein
Babesia bovis BBOV_III001990   CobW/P47K domain containing protein
Candida albicans CaO19_5165   hypothetical protein
Candida albicans CaO19.12632   similar to S. cerevisiae YNR029C
Candida albicans CaO19.5165   similar to S. cerevisiae YNR029C
Cryptosporidium hominis Chro.80108   cobW protein
Cryptosporidium parvum cgd8_890   CobW/nitrile hydratase activator like P-loop ATpase
Dictyostelium discoideum DDB_G0281589   COBW domain-containing protein
Escherichia coli b4352   GTP-binding protein, putative GTPase
Echinococcus granulosus EgrG_000613500   Cobalamin vitamin B12 biosynthesis CobW
Echinococcus multilocularis EmuJ_000613500   Cobalamin (vitamin B12) biosynthesis CobW
Homo sapiens ENSG00000147996   COBW domain containing 5
Homo sapiens 101060578   putative COBW domain-containing protein 7-like
Homo sapiens ENSG00000215126   COBW domain containing 6
Homo sapiens ENSG00000136682   COBW domain containing 2
Homo sapiens ENSG00000196873   COBW domain containing 3
Homo sapiens ENSG00000172785   COBW domain containing 1
Leishmania braziliensis LbrM.35.3390   hypothetical protein, conserved
Leishmania donovani LdBPK_363320.1   CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
Leishmania infantum LinJ.36.3320   hypothetical protein, conserved
Leishmania major LmjF.36.3170   hypothetical protein, conserved
Leishmania mexicana LmxM.36.3170   hypothetical protein, conserved
Mus musculus ENSMUSG00000024878   COBW domain containing 1
Neospora caninum NCLIV_033750   hypothetical protein
Oryza sativa 4343807   Os07g0598900
Oryza sativa 4331034   Os02g0800000
Plasmodium berghei PBANKA_1036700   COBW domain-containing protein 1, putative
Plasmodium falciparum PF3D7_1405500   COBW domain-containing protein 1, putative
Plasmodium knowlesi PKNH_1352600   COBW domain-containing protein 1, putative
Plasmodium vivax PVX_086160   COBW domain-containing protein 1, putative
Plasmodium yoelii PY03672   Homo sapiens HCOBP
Saccharomyces cerevisiae YNR029C   hypothetical protein
Schistosoma japonicum Sjp_0303110   COBW domain-containing protein 1, putative
Schistosoma mansoni Smp_036570   hypothetical protein
Schmidtea mediterranea mk4.000881.00  
Trypanosoma brucei gambiense Tbg972.11.10650   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.9490   CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
Trypanosoma congolense TcIL3000.11.9960   CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
Trypanosoma cruzi TcCLB.508851.150   CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
Trypanosoma cruzi TcCLB.511589.90   CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
Toxoplasma gondii TGME49_273990   CobW/P47K family protein
Theileria parva TP03_0601   hypothetical protein, conserved

Essentiality

TcCLB.508851.150 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.1250 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.1250 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.1250 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.1250 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b4352 Escherichia coli non-essential goodall
TGME49_273990 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.508851.150 (Trypanosoma cruzi), CobW/HypB/UreG, nucleotide-binding domain containing protein, putative
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