Detailed view for PF3D7_0502800

Basic information

TDR Targets ID: 4058
Plasmodium falciparum, DnaJ protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.2305 | Length (AA): 137 | MW (Da): 16408 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00226   DnaJ domain
PF05207   CSL zinc finger

Gene Ontology

Mouse over links to read term descriptions.
GO:0031072   heat shock protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 77 2cug (A) 15 82 35.00 0 0.88 1 -1.4
2 82 2ctr (A) 6 78 30.00 0 1 0.96 -1.2
4 73 1fpo (A) 2 71 16.00 0 0.23 0.77 -1.65
79 136 1yop (A) 1 58 29.00 0.00000000011 1 0.92 -1.18
84 136 1wge (A) 13 65 28.00 0 1 0.87 -1.31
2 69 2ys8 (A) 26 85 33.00 0.59 1 0.85765 -0.71
2 136 2l6l (A) 9 146 19.00 0 0.82 1.1554 0.63
4 66 2y4t (A) 394 451 40.00 0.066 0.95 0.923154 -0.58
5 74 2och (A) 7 66 27.00 0.00054 0.79 0.848949 -1.58
82 136 2jr7 (A) 4 58 27.00 0.000000013 0.98 0.74346 0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Female Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 48 hs, Oocyst, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_129180)

Species Accession Gene Product
Arabidopsis thaliana AT4G10130   DNAJ heat shock N-terminal domain-containing protein
Candida albicans CaO19.9568   DnaJ-like protein with potential CSL zinc finger domain similar to S. cerevisiae JJJ3 (YJR097W)
Candida albicans CaO19.2018   DnaJ-like protein with potential CSL zinc finger domain similar to S. cerevisiae JJJ3 (YJR097W)
Cryptosporidium hominis Chro.30124   hypothetical protein
Cryptosporidium parvum cgd3_930   DnaJ domain, possible zf-CSL following
Dictyostelium discoideum DDB_G0292980   DNAJ heat shock N-terminal domain-containing protein
Drosophila melanogaster Dmel_CG2911   CG2911 gene product from transcript CG2911-RB
Echinococcus granulosus EgrG_000255600   Heat shock protein DnaJ
Echinococcus multilocularis EmuJ_000255600   Heat shock protein DnaJ
Homo sapiens ENSG00000170946   DnaJ (Hsp40) homolog, subfamily C, member 24
Leishmania braziliensis LbrM.18.1530   chaperone protein DNAj, putative
Leishmania donovani LdBPK_181470.1   chaperone protein DnaJ, putative
Leishmania infantum LinJ.18.1470   chaperone protein DNAj, putative
Leishmania major LmjF.18.1490   chaperone protein DNAj, putative
Leishmania mexicana LmxM.18.1490   chaperone protein DNAj, putative
Mus musculus ENSMUSG00000027166   DnaJ (Hsp40) homolog, subfamily C, member 24
Oryza sativa 4347281   Os09g0460000
Oryza sativa 4345818   Os08g0474600
Onchocerca volvulus OVOC12585  
Plasmodium berghei PBANKA_1102500   DnaJ protein, putative
Plasmodium falciparum PF3D7_0502800   DnaJ protein, putative
Plasmodium knowlesi PKNH_1031100   DnaJ protein, putative
Plasmodium vivax PVX_097645   hypothetical protein, conserved
Plasmodium yoelii PY04661   hypothetical protein
Saccharomyces cerevisiae YJR097W   Jjj3p
Schmidtea mediterranea mk4.001448.01   DnaJ homolog subfamily C member 24
Trypanosoma brucei gambiense Tbg972.10.15090   chaperone protein DNAj, putative
Trypanosoma brucei Tb927.10.12530   chaperone protein DnaJ, putative
Trypanosoma congolense TcIL3000_10_11150   chaperone protein DnaJ, putative
Trypanosoma cruzi TcCLB.511261.20   chaperone DNAJ protein, putative
Trypanosoma cruzi TcCLB.509809.20   chaperone DNAJ protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0502800 (Plasmodium falciparum), DnaJ protein, putative
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