Detailed view for PF3D7_0504900

Basic information

TDR Targets ID: 4079
Plasmodium falciparum, conserved protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.5889 | Length (AA): 172 | MW (Da): 20093 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05608   Protein of unknown function (DUF778)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, early schizont, late schizont, late trophozoite, Oocyst, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile sporozoite, early ring, early trophozoite, late ring, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs. Otto TD
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_128960)

Species Accession Gene Product
Arabidopsis thaliana AT3G51040   RTE1-like protein
Arabidopsis thaliana AT2G26070   protein REVERSION-TO-ETHYLENE SENSITIVITY 1
Brugia malayi Bm1_15855   D4Ertd196e protein
Caenorhabditis elegans CELE_H20J04.6   Protein H20J04.6
Drosophila melanogaster Dmel_CG8372   CG8372 gene product from transcript CG8372-RA
Echinococcus granulosus EgrG_000547900   transmembrane protein 222
Entamoeba histolytica EHI_045240   hypothetical protein, conserved
Entamoeba histolytica EHI_045010   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000547900   transmembrane protein 222
Giardia lamblia GL50803_3636   D4Ertd196e protein-like protein
Homo sapiens ENSG00000186501   transmembrane protein 222
Leishmania braziliensis LbrM.27.0980   hypothetical protein, conserved
Leishmania donovani LdBPK_270760.1   Protein of unknown function (DUF778), putative
Leishmania infantum LinJ.27.0760   hypothetical protein, conserved
Leishmania major LmjF.27.0900   hypothetical protein, conserved
Leishmania mexicana LmxM.27.0900   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05923   D4Ertd196e protein
Mus musculus ENSMUSG00000028857   transmembrane protein 222
Neospora caninum NCLIV_031120   hypothetical protein
Oryza sativa 4339461   Os05g0539800
Oryza sativa 4334443   Os03g0799500
Oryza sativa 4325934   Os01g0711600
Onchocerca volvulus OVOC11521   Transmembrane protein 222 homolog
Plasmodium berghei PBANKA_1104500   conserved protein, unknown function
Plasmodium falciparum PF3D7_0504900   conserved protein, unknown function
Plasmodium knowlesi PKNH_1028700   conserved protein, unknown function
Plasmodium vivax PVX_097805   hypothetical protein, conserved
Plasmodium yoelii PY04879   hypothetical protein
Schistosoma japonicum Sjp_0059490   similar to Uncharacterized protein C1orf160, putative
Schistosoma mansoni Smp_055420.1   hypothetical protein
Schistosoma mansoni Smp_055420.2   hypothetical protein
Schmidtea mediterranea mk4.023977.00   Transmembrane protein 222
Schmidtea mediterranea mk4.002320.01   Transmembrane protein 222
Trypanosoma brucei gambiense Tbg972.10.6960   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.5740   Protein of unknown function (DUF778), putative
Trypanosoma cruzi TcCLB.509733.190   Protein of unknown function (DUF778), putative
Trypanosoma cruzi TcCLB.509645.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509645.19   hypothetical protein, conserved
Toxoplasma gondii TGME49_230610   transmembrane protein TMEM222
Trichomonas vaginalis TVAG_199110   conserved hypothetical protein
Trichomonas vaginalis TVAG_405720   conserved hypothetical protein

Essentiality

PF3D7_0504900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5740 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.5740 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.5740 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.5740 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_230610 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0504900 (Plasmodium falciparum), conserved protein, unknown function
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