pI: 8.8465 |
Length (AA): 336 |
MW (Da): 37052 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
142 | 319 | 1okc (A) | 5 | 196 | 33.00 | 0 | 0.61 | 0.8 | -0.12 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128339)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G46800 | mitochondrial carnitine/acylcarnitine carrier-like protein |
Brugia malayi | Bm1_36285 | Protein dif-1 |
Candida albicans | CaO19.10130 | likely mitochondrial carnitine transport protein similar to S. cerevisiae CRC1 (YOR100C) |
Candida albicans | CaO19.2599 | likely mitochondrial carnitine transport protein similar to S. cerevisiae CRC1 (YOR100C) |
Caenorhabditis elegans | CELE_F49E8.5 | Protein DIF-1 |
Dictyostelium discoideum | DDB_G0293556 | mitochondrial carnitine/acylcarnitine carrier protein |
Dictyostelium discoideum | DDB_G0290913 | mitochondrial substrate carrier family protein |
Drosophila melanogaster | Dmel_CG3057 | congested-like trachea |
Drosophila melanogaster | Dmel_CG3476 | CG3476 gene product from transcript CG3476-RA |
Echinococcus granulosus | EgrG_000775200 | mitochondrial carnitine:acylcarnitine carrier |
Echinococcus multilocularis | EmuJ_000775200 | mitochondrial carnitine:acylcarnitine carrier |
Homo sapiens | ENSG00000178537 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 |
Leishmania braziliensis | LbrM.16.0210 | mitochondrial ornithine carrier protein-like protein |
Leishmania donovani | LdBPK_160210.1 | mitochondrial ornithine carrier protein-like protein |
Leishmania infantum | LinJ.16.0210 | mitochondrial ornithine carrier protein-like protein |
Leishmania major | LmjF.16.0200 | mitochondrial ornithine carrier protein-like protein |
Leishmania mexicana | LmxM.16.0200 | mitochondrial ornithine carrier protein-like protein |
Loa Loa (eye worm) | LOAG_03066 | dif-1 |
Mus musculus | ENSMUSG00000032602 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 |
Oryza sativa | 4349476 | Os10g0573800 |
Oryza sativa | 4349475 | Os10g0573700 |
Saccharomyces cerevisiae | YOR100C | Crc1p |
Schistosoma japonicum | Sjp_0052160 | ko:K03454 mitochondrial carrier protein, MC family, putative |
Schistosoma mansoni | Smp_064150 | mitochondrial carnitine/acylcarnitine carrier protein-related |
Schmidtea mediterranea | mk4.000566.03 | Mitochondrial carnitine/acylcarnitine carrier protein |
Schmidtea mediterranea | mk4.002387.00 | Mitochondrial carnitine/acylcarnitine carrier protein CACL |
Trypanosoma brucei gambiense | Tbg972.8.5810 | mitochondrial carrier protein, putative,mitochondrial carnitine/acylcarnitine carrier protein |
Trypanosoma brucei gambiense | Tbg972.11.5970 | mitochondrial carrier protein, putative |
Trypanosoma brucei | Tb927.11.5290 | mitochondrial carrier protein |
Trypanosoma brucei | Tb927.8.5810 | mitochondrial carrier protein |
Trypanosoma congolense | TcIL3000.11.5540 | mitochondrial carrier protein |
Trypanosoma congolense | TcIL3000_8_5610 | mitochondrial carrier protein |
Trypanosoma congolense | TcIL3000_0_57240 | mitochondrial carrier protein |
Trypanosoma congolense | TcIL3000.11.5530 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.509109.114 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.504217.19 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.506221.40 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.504131.190 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.510603.90 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.504125.50 | mitochondrial carrier protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.2960 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2960 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2960 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.2960 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.8.5810 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5810 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5810 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.8.5810 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F49E8.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 | Compounds | References |