Detailed view for TcCLB.510719.30

Basic information

TDR Targets ID: 41360
Trypanosoma cruzi, ribosomal protein L29, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 12.8836 | Length (AA): 71 | MW (Da): 8259 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01779   Ribosomal L29e protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127199)

Species Accession Gene Product
Arabidopsis thaliana AT3G06700   60S ribosomal protein L29-1
Arabidopsis thaliana AT3G06680   60S ribosomal protein L29-2
Babesia bovis BBOV_III010620   ribosomal L29e protein family protein
Brugia malayi Bm1_19125   60S ribosomal protein L29
Caenorhabditis elegans CELE_B0513.3   Protein RPL-29, isoform B
Cryptosporidium parvum cgd2_120   ribosomal protein L29
Dictyostelium discoideum DDB_G0281469   S60 ribosomal protein L29
Drosophila melanogaster Dmel_CG10071   Ribosomal protein L29
Entamoeba histolytica EHI_023220   hypothetical protein
Giardia lamblia GL50803_14457   Ripening regulated protein DDTFR19
Homo sapiens ENSG00000162244   ribosomal protein L29
Leishmania braziliensis LbrM.35.3620   ribosomal protein L29, putative
Leishmania braziliensis LbrM.35.3630   ribosomal protein L29, putative
Leishmania donovani LdBPK_363560.1   ribosomal protein L29, putative
Leishmania donovani LdBPK_363550.1   ribosomal protein L29, putative
Leishmania infantum LinJ.36.3560   ribosomal protein L29, putative
Leishmania infantum LinJ.36.3550   ribosomal protein L29, putative
Leishmania major LmjF.36.3400   ribosomal protein L29, putative
Leishmania major LmjF.36.3390   ribosomal protein L29, putative
Leishmania mexicana LmxM.36.3390   ribosomal protein L29, putative
Leishmania mexicana LmxM.36.3400   ribosomal protein L29, putative
Loa Loa (eye worm) LOAG_10081   60S ribosomal protein L29
Mus musculus 102642233   60S ribosomal protein L29-like
Mus musculus 102640205   60S ribosomal protein L29-like
Mus musculus 102632402   60S ribosomal protein L29-like
Mus musculus 102642274   60S ribosomal protein L29-like
Mus musculus 666389   predicted gene 12447
Mus musculus ENSMUSG00000048758   ribosomal protein L29
Mus musculus 102641055   60S ribosomal protein L29-like
Mus musculus 545683   predicted gene 13213
Mus musculus 102642738   60S ribosomal protein L29-like
Mus musculus 102640679   60S ribosomal protein L29-like
Mus musculus 102639915   60S ribosomal protein L29-like
Mus musculus 102642766   60S ribosomal protein L29-like
Mus musculus 670211   predicted gene 12508
Mus musculus 383770   predicted gene 11449
Mus musculus 102634483   60S ribosomal protein L29-like
Mus musculus 100503055   60S ribosomal protein L29-like
Neospora caninum NCLIV_042250   Ribosomal protein L29, related
Oryza sativa 4338517   Os05g0355500
Plasmodium berghei PBANKA_1324000   60S ribosomal protein L29, putative
Plasmodium falciparum PF3D7_1460300   60S ribosomal protein L29, putative
Plasmodium knowlesi PKNH_1221400   60S ribosomal protein L29, putative
Plasmodium vivax PVX_117440   60S ribosomal protein L29, putative
Saccharomyces cerevisiae YFR032C-A   ribosomal 60S subunit protein L29
Schistosoma japonicum Sjp_0001920   ko:K02905 large subunit ribosomal protein L29e, putative
Schistosoma mansoni Smp_066940   60S ribosomal protein L29
Trypanosoma brucei gambiense Tbg972.11.11270   60S ribosomal protein L29, putative
Trypanosoma brucei gambiense Tbg972.11.11260   60S ribosomal protein L29, putative
Trypanosoma brucei Tb927.11.10030   60S ribosomal protein L29, putative
Trypanosoma cruzi TcCLB.509749.33   ribosomal protein L29, putative
Trypanosoma cruzi TcCLB.510719.35   ribosomal protein L29, putative
Trypanosoma cruzi TcCLB.510719.30   ribosomal protein L29, putative
Trypanosoma cruzi TcCLB.509749.36   ribosomal protein L29, putative
Toxoplasma gondii TGME49_234550   ribosomal protein RPL29
Theileria parva TP02_0080   60S ribosomal protein L29e, putative
Trichomonas vaginalis TVAG_413370   conserved hypothetical protein
Trichomonas vaginalis TVAG_021190   conserved hypothetical protein
Trichomonas vaginalis TVAG_158840   conserved hypothetical protein
Trichomonas vaginalis TVAG_451230   conserved hypothetical protein
Trichomonas vaginalis TVAG_083040   conserved hypothetical protein

Essentiality

TcCLB.510719.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1324000 Plasmodium berghei Slow plasmo
TGME49_234550 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.510719.30 (Trypanosoma cruzi), ribosomal protein L29, putative
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