Detailed view for PF3D7_0511000

Basic information

TDR Targets ID: 4141
Plasmodium falciparum, translationally-controlled tumor protein homolog
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.3088 | Length (AA): 171 | MW (Da): 19979 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00838   Translationally controlled tumour protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 171 1txj (A) 1 171 85.00 0 1 1.97 -1.49
1 171 1h6q (A) 1 168 39.00 0 1 1.46 -0.26
1 171 3p3k (A) 5 175 99.99 0 1 2.0858 -1.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1TXJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3P3K:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127617)

Species Accession Gene Product
Arabidopsis thaliana AT3G05540   methionine sulfoxide reductase 4-like protein
Arabidopsis thaliana AT3G16640   translationally-controlled tumor protein-like protein
Babesia bovis BBOV_IV004730   histamine-releasing factor, putative
Brugia malayi Bm1_31480   Translationally controlled tumor protein
Candida albicans CaO19.10778   similar to Human tumor protein
Candida albicans CaO19.3268   similar to Human tumor protein
Caenorhabditis elegans CELE_F25H2.11   Protein TCT-1
Cryptosporidium hominis Chro.30228   histamine-releasing factor
Cryptosporidium parvum cgd3_1940   conserved hypothetical protein
Dictyostelium discoideum DDB_G0282853   hypothetical protein
Drosophila melanogaster Dmel_CG4800   Translationally controlled tumor protein ortholog (H. sapiens)
Echinococcus granulosus EgrG_000058000   translationally controlled tumor protein
Entamoeba histolytica EHI_021360   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000058000   translationally controlled tumor protein
Giardia lamblia GL50803_6242   Translationally controlled tumor protein-like protein
Homo sapiens 392490   TPT1-like protein
Homo sapiens ENSG00000133112   tumor protein, translationally-controlled 1
Leishmania braziliensis LbrM.24.1350   IgE-dependent histamine-releasing factor, putative
Leishmania donovani LdBPK_241560.1   IgE-dependent histamine-releasing factor, putative
Leishmania infantum LinJ.24.1560   IgE-dependent histamine-releasing factor, putative
Leishmania infantum LinJ.24.1570   IgE-dependent histamine-releasing factor, putative
Leishmania major LmjF.24.1500   IgE-dependent histamine-releasing factor, putative
Leishmania major LmjF.24.1510   IgE-dependent histamine-releasing factor, putative
Leishmania mexicana LmxM.24.1500   IgE-dependent histamine-releasing factor, putative
Leishmania mexicana LmxM.24.1500a  
Loa Loa (eye worm) LOAG_00385   translationally controlled tumor protein
Mus musculus 22070   tumor protein, translationally-controlled 1
Neospora caninum NCLIV_066760   Translationally-controlled tumor protein, related
Oryza sativa 4351061   Os11g0660500
Plasmodium berghei PBANKA_1110500   translationally-controlled tumor protein homolog
Plasmodium falciparum PF3D7_0511000   translationally-controlled tumor protein homolog
Plasmodium knowlesi PKNH_1022600   translationally-controlled tumor protein homolog, putative
Plasmodium vivax PVX_080685   translationally-controlled tumor protein homolog, putative
Plasmodium yoelii PY04896   translationally controlled tumor protein
Saccharomyces cerevisiae YKL056C   Tma19p
Schistosoma japonicum Sjp_0075160   Translationally-controlled tumor protein homolog, putative
Schistosoma mansoni Smp_054240   Translationally-controlled tumor protein homolog (TCTP) (Histamine-releasing factor)
Schmidtea mediterranea mk4.021870.00   Translationally-controlled tumor protein homolog
Schmidtea mediterranea mk4.024463.00   Translationally-controlled tumor protein homolog
Schmidtea mediterranea mk4.003250.02   Translationally-controlled tumor protein homolog
Schmidtea mediterranea mk4.003250.00   Translationally-controlled tumor protein homolog
Schmidtea mediterranea mk4.010385.00   Translationally-controlled tumor protein homolog
Trypanosoma brucei gambiense Tbg972.8.6940   IgE-dependent histamine-releasing factor, putative
Trypanosoma brucei gambiense Tbg972.8.6930   translationally controlled tumor protein (TCTP), putative,IgE-dependent histamine-releasing factor, putative
Trypanosoma brucei Tb927.8.6750   translationally controlled tumor protein (TCTP), putative
Trypanosoma brucei Tb927.8.6760   translationally-controlled tumor protein homolog, putative
Trypanosoma congolense TcIL3000_8_6640   translationally controlled tumor protein (TCTP), putative
Trypanosoma congolense TcIL3000_8_6650   translationally controlled tumor protein (TCTP), putative
Trypanosoma cruzi TcCLB.510065.30   translationally controlled tumor protein (TCTP), putative
Trypanosoma cruzi TcCLB.506207.50   translationally controlled tumor protein (TCTP), putative
Toxoplasma gondii TGME49_251680   histamine-releasing factor, putative
Theileria parva TP01_0276   translationally controlled tumor protein, putative
Trichomonas vaginalis TVAG_180840   conserved hypothetical protein
Trichomonas vaginalis TVAG_102670   conserved hypothetical protein

Essentiality

PF3D7_0511000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.6750 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.6750 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.6750 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F25H2.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_F25H2.11 Caenorhabditis elegans larval arrest wormbase
CELE_F25H2.11 Caenorhabditis elegans slow growth wormbase
CELE_F25H2.11 Caenorhabditis elegans sterile wormbase
PBANKA_1110500 Plasmodium berghei Slow plasmo
TGME49_251680 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0511000 (Plasmodium falciparum), translationally-controlled tumor protein homolog
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