pI: 8.4482 |
Length (AA): 472 |
MW (Da): 52437 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 472 | 1k3p (A) | 3 | 423 | 23.00 | 0 | 1 | 1.06 | -0.04 |
23 | 467 | 1csc () | 1 | 432 | 50.00 | 0 | 1 | 1.54 | -1.4 |
23 | 470 | 3enj (A) | 4 | 435 | 51.00 | 0 | 1 | 1.55885 | -0.67 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | metacyclic. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127570)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G44350 | citrate synthase 4 |
Arabidopsis thaliana | AT3G60100 | citrate synthase 5 |
Babesia bovis | BBOV_II006920 | citrate synthase |
Brugia malayi | Bm1_19445 | Probable citrate synthase, mitochondrial precursor, putative |
Candida albicans | CaO19.4393 | nuclear citrate synthase |
Candida albicans | CaO19.11871 | nuclear citrate synthase |
Caenorhabditis elegans | CELE_T20G5.2 | Protein CTS-1 |
Dictyostelium discoideum | DDB_G0275311 | citrate synthase, mitochondrial |
Drosophila melanogaster | Dmel_CG3861 | knockdown |
Echinococcus granulosus | EgrG_001028500 | citrate synthase |
Echinococcus multilocularis | EmuJ_001028500 | citrate synthase |
Homo sapiens | ENSG00000257727 | canopy FGF signaling regulator 2 |
Homo sapiens | ENSG00000062485 | citrate synthase |
Leishmania braziliensis | LbrM.18.0760 | citrate synthase, putative |
Leishmania braziliensis | LbrM.18.0770 | citrate synthase, putative |
Leishmania infantum | LinJ.18.0700 | citrate synthase, putative |
Leishmania infantum | LinJ.18.0690 | citrate synthase, putative |
Leishmania major | LmjF.18.0680 | citrate synthase, putative |
Leishmania major | LmjF.18.0670 | citrate synthase, putative |
Leishmania mexicana | LmxM.18.0680 | citrate synthase, putative |
Leishmania mexicana | LmxM.18.0670 | citrate synthase, putative |
Loa Loa (eye worm) | LOAG_03295 | citrate synthase |
Mus musculus | ENSMUSG00000046934 | citrate synthase like |
Mus musculus | ENSMUSG00000005683 | citrate synthase |
Neospora caninum | NCLIV_037460 | hypothetical protein |
Oryza sativa | 4350660 | Os11g0538900 |
Oryza sativa | 4328598 | Os02g0194100 |
Plasmodium berghei | PBANKA_0506700 | citrate synthase, mitochondrial, putative |
Plasmodium falciparum | PF3D7_1022500 | citrate synthase, mitochondrial, putative |
Plasmodium knowlesi | PKNH_0606800 | citrate synthase, mitochondrial, putative |
Plasmodium vivax | PVX_224290 | unspecified product |
Plasmodium vivax | PVX_111595 | citrate synthase, mitochondrial precursor, putative |
Plasmodium vivax | PVX_228290 | unspecified product |
Plasmodium yoelii | PY01660 | probable citrate synthase, mitochondrial precursor |
Saccharomyces cerevisiae | YNR001C | citrate (Si)-synthase CIT1 |
Saccharomyces cerevisiae | YCR005C | citrate (Si)-synthase CIT2 |
Saccharomyces cerevisiae | YPR001W | citrate (Si)-synthase CIT3 |
Schistosoma japonicum | Sjp_0037110 | ko:K01647 citrate synthase [EC2.3.3.1], putative |
Trypanosoma brucei gambiense | Tbg972.10.16220 | citrate synthase, putative |
Trypanosoma brucei | Tb927.10.13430 | citrate synthase, putative |
Trypanosoma congolense | TcIL3000_10_11540 | citrate synthase, putative |
Trypanosoma cruzi | TcCLB.511277.110 | citrate synthase, putative |
Trypanosoma cruzi | TcCLB.509801.30 | citrate synthase, putative |
Toxoplasma gondii | TGME49_268890 | citrate synthase I |
Theileria parva | TP02_0666 | citrate synthase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.13430 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.13430 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.13430 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.13430 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T20G5.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T20G5.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T20G5.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T20G5.2 | Caenorhabditis elegans | sterile | wormbase |
TGME49_268890 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Saccharomyces cerevisiae | citrate (Si)-synthase CIT2 | Compounds | References |