Detailed view for PF3D7_0514300

Basic information

TDR Targets ID: 4175
Plasmodium falciparum, aspartate--tRNA ligase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.2083 | Length (AA): 1128 | MW (Da): 134776 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00152   tRNA synthetases class II (D, K and N)

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0005737   cytoplasm  
GO:0004815   aspartate-tRNA ligase activity  
GO:0004812   aminoacyl-tRNA ligase activity  
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  
GO:0016874   ligase activity  
GO:0005524   ATP binding  
GO:0006422   aspartyl-tRNA aminoacylation  
GO:0006418   tRNA aminoacylation for protein translation  
GO:0006412   translation  

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
370 1125 1l0w (A) 16 546 16.00 0 0.92 0.33 1.23
886 1124 1b8a (A) 219 426 25.00 0.0000000000047 0.86 0.39 -0.25
579 930 4n5c (E) 39 404 22.00 0.59 0.75 0.352857 0.64
609 660 4o2d (B) 185 235 47.00 0.2 0.13 0.371899 0.87
691 1038 2vk9 (A) 159 503 25.00 0.54 0.98 0.141311 1.55
972 1125 1eov (A) 419 546 32.00 0.0000000072 0.94 0.244325 0.96
973 1124 1wyd (A) 298 417 36.00 0.00024 0.36 0.0365518 1.94
313 890 3vuo (A) 181 808 22.00 0.12 1 0.559386 1.18
548 674 1c0a (A) 131 260 24.00 0.000074 0.36 0.331901 -0.05
567 920 4n5c (E) 39 397 22.00 0.9 0.53 0.319489 0.7
584 685 3nem (A) 167 270 33.00 0.00000084 0.11 0.25748 1.54
880 1112 1eov (A) 327 546 23.00 0.00000000042 0.92 0.240169 0.62
930 1109 3kfu (A) 259 408 29.00 0.0000026 0.93 0.240435 0.91
960 1111 1wyd (A) 298 417 36.00 0.00025 0.36 0.0373229 1.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, early trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, gametocyte. Otto TD PlasmoDB
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_167278)

Species Accession Gene Product
Plasmodium berghei PBANKA_1114000   aspartate--tRNA ligase, putative
Plasmodium falciparum PF3D7_0514300   aspartate--tRNA ligase, putative
Plasmodium knowlesi PKNH_1018800   aspartate--tRNA ligase, putative
Plasmodium vivax PVX_080525   aspartate--tRNA ligase, putative
Plasmodium yoelii PY01996   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0514300 (Plasmodium falciparum), aspartate--tRNA ligase, putative
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