Detailed view for TcCLB.511285.50

Basic information

TDR Targets ID: 41772
Trypanosoma cruzi, root hair defective 3 GTP-binding protein (RHD3), putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.6529 | Length (AA): 877 | MW (Da): 99185 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05879   Root hair defective 3 GTP-binding protein (RHD3)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 682 5ca9 (A) 29 686 19.00 0.00028 1 0.891768 0.7
15 661 5ca8 (A) 31 674 23.00 0 1 0.918642 0.14
48 654 5ca8 (A) 54 667 29.00 0 1 0.883132 0.63
571 731 4uos (A) 7 176 5.00 0.024 0 0.15838 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128997)

Species Accession Gene Product
Arabidopsis thaliana AT5G45160   Root hair defective 3 GTP-binding protein (RHD3)
Arabidopsis thaliana AT1G72960   Root hair defective 3 GTP-binding protein (RHD3)
Arabidopsis thaliana AT3G13870   protein ROOT HAIR DEFECTIVE 3
Babesia bovis BBOV_II001090   root hair defective 3 GTP binding protein, putative
Candida albicans CaO19.2151   similar to S. cerevisiae SEY1 involved in vesicular traffic in stressed cells
Candida albicans CaO19.9698   similar to S. cerevisiae SEY1 involved in vesicular traffic in stressed cells
Cryptosporidium hominis Chro.80282   hypothetical protein
Cryptosporidium parvum cgd8_2410   Sey1p like P-loop GTpase of the RHD3 subfamily with a transmembrane domain near C-terminus
Dictyostelium discoideum DDB_G0279823   hypothetical protein
Entamoeba histolytica EHI_054180   GTP-binding protein, putative
Entamoeba histolytica EHI_012280   hypothetical protein, conserved
Giardia lamblia GL50803_32509   Hypothetical protein
Leishmania braziliensis LbrM.32.0440   hypothetical protein, conserved
Leishmania donovani LdBPK_320380.1   root hair defective 3 GTP-binding protein (RHD3), putative
Leishmania infantum LinJ.32.0380   hypothetical protein, conserved
Leishmania major LmjF.32.0370   hypothetical protein, conserved
Leishmania mexicana LmxM.31.0370   hypothetical protein, conserved
Neospora caninum NCLIV_057820   hypothetical protein
Oryza sativa 4326314   Os01g0575000
Oryza sativa 4350788   Os11g0582300
Oryza sativa 4352733   Os12g0604600
Plasmodium berghei PBANKA_1026600   protein SEY1, putative
Plasmodium falciparum PF3D7_1416100   protein SEY1, putative
Plasmodium knowlesi PKNH_1342000   protein SEY1, putative
Plasmodium vivax PVX_085645   hypothetical protein, conserved
Plasmodium yoelii PY06299   hypothetical protein
Plasmodium yoelii PY06298   hypothetical protein
Saccharomyces cerevisiae YOR165W   dynamin-like GTPase SEY1
Trypanosoma brucei gambiense Tbg972.10.17650   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.14510   root hair defective 3 GTP-binding protein (RHD3), putative
Trypanosoma congolense TcIL3000_10_12410   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.398345.10   root hair defective 3 GTP-binding protein (RHD3), putative
Trypanosoma cruzi TcCLB.511285.50   root hair defective 3 GTP-binding protein (RHD3), putative
Trypanosoma cruzi TcCLB.509649.59   root hair defective 3 GTP-binding protein (RHD3), putative
Toxoplasma gondii TGME49_314970   root hair defective 3 gtp-binding protein (rhd3) protein
Theileria parva TP04_0477   hypothetical protein, conserved
Theileria parva TP04_0476   hypothetical protein
Trichomonas vaginalis TVAG_100140   protein SEY1, putative
Trichomonas vaginalis TVAG_273580   protein sey1, putative
Trichomonas vaginalis TVAG_204380   protein sey1, putative

Essentiality

TcCLB.511285.50 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14510 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.14510 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_314970 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TcCLB.511285.50 (Trypanosoma cruzi), root hair defective 3 GTP-binding protein (RHD3), putative
Title for this comment
Comment