pI: 8.1567 |
Length (AA): 144 |
MW (Da): 15164 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 143 | 2gel (A) | 1 | 120 | 18.00 | 0 | 0.62 | 1.06 | -0.78 |
7 | 144 | 3wuh (A) | 31 | 176 | 31.00 | 0 | 1 | 1.32163 | -0.33 |
8 | 144 | 3en9 (A) | 0 | 133 | 47.00 | 0 | 1 | 1.52669 | -0.35 |
9 | 144 | 2ivn (A) | 1 | 133 | 47.00 | 0 | 1 | 1.54684 | -0.61 |
50 | 116 | 2gel (A) | 31 | 93 | 30.00 | 0.02 | 0.99 | 0.813678 | -0.18 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126710)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G22720 | Actin-like ATPase superfamily protein |
Arabidopsis thaliana | AT2G45270 | glycoprotease 1 |
Babesia bovis | BBOV_II003000 | glycoprotease family protein |
Babesia bovis | BBOV_III009430 | glycoprotease family protein |
Brugia malayi | Bm1_18960 | Probable O-sialoglycoprotein endopeptidase |
Brugia malayi | Bm1_52875 | Glycoprotease family protein |
Candida albicans | CaO19.11636 | likely glycoprotease similar to S. cerevisiae QRI7 |
Candida albicans | CaO19.4160 | likely glycoprotease similar to S. cerevisiae QRI7 |
Candida albicans | CaO19.11267 | similar to S. cerevisiae Kinase-Associated Endopeptidase 1 |
Candida albicans | CaO19.3787 | similar to S. cerevisiae Kinase-Associated Endopeptidase 1 |
Caenorhabditis elegans | CELE_C01G10.10 | Protein C01G10.10 |
Caenorhabditis elegans | CELE_Y71H2AM.1 | Protein Y71H2AM.1 |
Cryptosporidium hominis | Chro.60410 | endopeptidase |
Cryptosporidium parvum | cgd6_3550 | endopeptidase, putative |
Chlamydia trachomatis | CT_197 | metal dependent protease |
Dictyostelium discoideum | DDB_G0267512 | hypothetical protein |
Dictyostelium discoideum | DDB_G0291299 | hypothetical protein |
Drosophila melanogaster | Dmel_CG14231 | CG14231 gene product from transcript CG14231-RB |
Drosophila melanogaster | Dmel_CG4933 | CG4933 gene product from transcript CG4933-RA |
Escherichia coli | b3064 | tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein |
Echinococcus granulosus | EgrG_000968400 | tRNA threonylcarbamoyladenosine |
Echinococcus granulosus | EgrG_000105300 | tRNA threonylcarbamoyladenosine |
Entamoeba histolytica | EHI_024630 | glycoprotein endopeptidase, putative |
Echinococcus multilocularis | EmuJ_000105300 | tRNA threonylcarbamoyladenosine |
Echinococcus multilocularis | EmuJ_000968400 | tRNA threonylcarbamoyladenosine |
Giardia lamblia | GL50803_17420 | O-sialoglycoprotein endopeptidase |
Homo sapiens | ENSG00000128694 | O-sialoglycoprotein endopeptidase-like 1 |
Homo sapiens | ENSG00000092094 | O-sialoglycoprotein endopeptidase |
Leishmania braziliensis | LbrM.31.0100 | O-sialoglycoprotein endopeptidase, putative,metallo-peptidase, Clan MK, Family M67 |
Leishmania donovani | LdBPK_310110.1 | O-sialoglycoprotein endopeptidase, putative |
Leishmania infantum | LinJ.31.0110 | O-sialoglycoprotein endopeptidase, putative,metallo-peptidase, Clan MK, Family M67 |
Leishmania major | LmjF.31.0100 | O-sialoglycoprotein endopeptidase, putative,metallo-peptidase, Clan MK, Family M67 |
Leishmania mexicana | LmxM.30.0100 | O-sialoglycoprotein endopeptidase, putative,metallo-peptidase, Clan MK, Family M67 |
Loa Loa (eye worm) | LOAG_10294 | glycoprotease |
Loa Loa (eye worm) | LOAG_02821 | osgep-prov protein |
Mycobacterium leprae | ML0379 | Probable O-sialoglycoprotein endopeptidase Gcp (Glycoprotease) |
Mus musculus | 66246 | O-sialoglycoprotein endopeptidase |
Mus musculus | ENSMUSG00000026096 | O-sialoglycoprotein endopeptidase-like 1 |
Mycobacterium tuberculosis | Rv3419c | Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) |
Mycobacterium ulcerans | MUL_0884 | putative DNA-binding/iron metalloprotein/AP endonuclease |
Neospora caninum | NCLIV_022600 | glycoprotease family domain-containing protein, putative |
Oryza sativa | 9270395 | Os12g0485000 |
Oryza sativa | 4338033 | Os05g0194600 |
Oryza sativa | 4326718 | Os01g0295900 |
Plasmodium berghei | PBANKA_0514600 | tRNA N6-adenosine threonylcarbamoyltransferase, putative |
Plasmodium falciparum | PF3D7_1030600 | tRNA N6-adenosine threonylcarbamoyltransferase |
Plasmodium knowlesi | PKNH_0615300 | tRNA N6-adenosine threonylcarbamoyltransferase, putative |
Plasmodium vivax | PVX_111195 | tRNA N6-adenosine threonylcarbamoyltransferase, putative |
Plasmodium yoelii | PY00526 | O-sialoglycoprotease-related |
Saccharomyces cerevisiae | YDL104C | Qri7p |
Saccharomyces cerevisiae | YKR038C | Kae1p |
Schistosoma japonicum | Sjp_0304730 | ko:K01409 O-sialoglycoprotein endopeptidase [EC3.4.24.57], putative |
Schistosoma japonicum | Sjp_0109990 | Probable O-sialoglycoprotein endopeptidase, putative |
Schistosoma japonicum | Sjp_0311990 | ko:K01409 O-sialoglycoprotein endopeptidase [EC3.4.24.57], putative |
Schistosoma mansoni | Smp_125030 | peptidase |
Schistosoma mansoni | Smp_012450 | Kae1 peptidase (M22 family) |
Schmidtea mediterranea | mk4.000023.21 | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial |
Schmidtea mediterranea | mk4.054239.01 | |
Trypanosoma brucei gambiense | Tbg972.7.7480 | O-sialoglycoprotein endopeptidase, putative,metallo-peptidase, Clan MK, Family M67 |
Trypanosoma brucei | Tb927.7.6470 | metallo-peptidase, Clan MK, Family M67 |
Trypanosoma congolense | TcIL3000_7_5370 | metallo-peptidase, Clan MK, Family M67, putative |
Trypanosoma cruzi | TcCLB.506515.20 | O-sialoglycoprotein endopeptidase, putative |
Trypanosoma cruzi | TcCLB.508913.39 | O-sialoglycoprotein endopeptidase, putative |
Trypanosoma cruzi | TcCLB.511321.4 | O-sialoglycoprotein endopeptidase, putative |
Toxoplasma gondii | TGME49_202310 | O-sialoglycoprotein endopeptidase |
Treponema pallidum | TP0680 | DNA-binding/iron metalloprotein/AP endonuclease |
Theileria parva | TP04_0853 | hypothetical protein |
Theileria parva | TP04_0852 | glycoprotein endopeptidase, putative |
Theileria parva | TP04_0293 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_185400 | Clan MK, familly M22, sialoglycoprotein endopeptidase-like metallopeptidase |
Wolbachia endosymbiont of Brugia malayi | Wbm0217 | DNA-binding/iron metalloprotein/AP endonuclease |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3480 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.7.6470 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.6470 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.6470 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.6470 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3064 | Escherichia coli | essential | goodall |
YKR038C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_202310 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.