pI: 8.2052 |
Length (AA): 716 |
MW (Da): 84057 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
70 | 146 | 2d9p (A) | 292 | 375 | 21.00 | 0.0000087 | 0.48 | 0.26 | -0.27 |
179 | 586 | 1l0q (A) | 5 | 389 | 10.00 | 0 | 1 | 0.32 | 0.2 |
43 | 134 | 2fy1 (A) | 2 | 78 | 35.00 | 0.97 | 0.97 | 0.347092 | 0.28 |
166 | 615 | 4u1f (A) | 150 | 625 | 30.00 | 0 | 1 | 0.780092 | 0.38 |
176 | 615 | 4nox (A) | 168 | 636 | 30.00 | 0 | 1 | 0.863125 | -0.19 |
657 | 714 | 1lq7 (A) | 3 | 64 | 28.00 | 0.75 | 0.35 | 0.444406 | -1.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Female Gametocyte, Male Gametocyte. | Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Sporozoite. | Zanghi G |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_128215)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G27640 | translation initiation factor 3 subunit B |
Arabidopsis thaliana | AT5G25780 | eukaryotic translation initiation factor 3B-2 |
Babesia bovis | BBOV_II003250 | eukaryotic translation initiation factor 3 subunit, putative |
Brugia malayi | Bm1_55275 | Eif3s9 protein |
Candida albicans | CaO19.13937 | translation initiation factor eIF3 subunit |
Candida albicans | CaO19_6584 | hypothetical protein |
Candida albicans | CaO19.6584 | translation initiation factor eIF3 subunit |
Caenorhabditis elegans | CELE_Y54E2A.11 | Protein EIF-3.B, isoform B |
Cryptosporidium hominis | Chro.20043 | hypothetical protein |
Cryptosporidium parvum | cgd2_360 | prtip-like IF39 eukaryotic translation initiation factor 3 |
Dictyostelium discoideum | DDB_G0283597 | RNA recognition motif-containing protein RRM |
Drosophila melanogaster | Dmel_CG4878 | CG4878 gene product from transcript CG4878-RB |
Echinococcus granulosus | EgrG_000445000 | eukaryotic translation initiation factor 3 |
Entamoeba histolytica | EHI_189410 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_051580 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000445000 | eukaryotic translation initiation factor 3 |
Homo sapiens | ENSG00000106263 | eukaryotic translation initiation factor 3, subunit B |
Leishmania braziliensis | LbrM.17.1450 | translation initiation factor, putative |
Leishmania donovani | LdBPK_171390.1 | eukaryotic translation initiation factor 3 subunit b |
Leishmania infantum | LinJ.17.1390 | translation initiation factor, putative |
Leishmania major | LmjF.17.1290 | translation initiation factor, putative |
Leishmania mexicana | LmxM.17.1290 | translation initiation factor, putative |
Loa Loa (eye worm) | LOAG_06233 | Eif3s9 protein |
Mus musculus | ENSMUSG00000056076 | eukaryotic translation initiation factor 3, subunit B |
Neospora caninum | NCLIV_005900 | TRANSLATION INITIATION FACTOR 3 SUBUNIT 9-like protein, related |
Oryza sativa | 4349446 | Os10g0569200 |
Plasmodium berghei | PBANKA_1232500 | eukaryotic translation initiation factor 3 subunit B, putative |
Plasmodium falciparum | PF3D7_0517700 | eukaryotic translation initiation factor 3 subunit B, putative |
Plasmodium knowlesi | PKNH_1015600 | eukaryotic translation initiation factor 3 subunit B, putative |
Plasmodium vivax | PVX_080365 | Eukaryotic translation initiation factor 3 subunit 9, putative |
Plasmodium yoelii | PY01620 | hypothetical protein |
Saccharomyces cerevisiae | YOR361C | Prt1p |
Schistosoma japonicum | Sjp_0217830 | ko:K03253 translation initiation factor eIF-3 subunit 9, putative |
Schistosoma japonicum | Sjp_0128900 | IPR011400,Translation initiation factor eIF-3b,domain-containing |
Schistosoma mansoni | Smp_058460 | eukaryotic translation initiation factor 3 (eif3)-related |
Schmidtea mediterranea | mk4.000551.02 | Eukaryotic translation initiation factor 3 subunit B |
Trypanosoma brucei gambiense | Tbg972.5.3620 | translation initiation factor, putative |
Trypanosoma brucei | Tb927.5.2570 | eukaryotic translation initiation factor 3 subunit b |
Trypanosoma congolense | TcIL3000_5_2520 | eukaryotic translation initiation factor 3 subunit b |
Trypanosoma cruzi | TcCLB.511303.60 | eukaryotic translation initiation factor 3 subunit b |
Toxoplasma gondii | TGME49_222860 | eukaryotic translation initiation factor, putative |
Theileria parva | TP04_0268 | hypothetical protein |
Trichomonas vaginalis | TVAG_333940 | eukaryotic translation initiation factor 3 subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.2570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.2570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.2570 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.5.2570 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y54E2A.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y54E2A.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y54E2A.11 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y54E2A.11 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y54E2A.11 | Caenorhabditis elegans | sterile | wormbase |
YOR361C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1232500 | Plasmodium berghei | Essential | plasmo |
TGME49_222860 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.