Detailed view for TcCLB.506239.30

Basic information

TDR Targets ID: 42091
Trypanosoma cruzi, lectin, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.3379 | Length (AA): 550 | MW (Da): 64016 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03388   Legume-like lectin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
45 271 1gv9 (A) 50 270 28.00 0 1 0.83 -1.33
54 282 1sbf () 5 234 16.00 0 1 0.48 -0.39
30 269 1r1z (A) 32 268 28.00 0 1 0.794864 -1.2
46 269 2dur (A) 51 269 35.00 0 1 0.911573 -1.32
71 274 2a6z (A) 30 221 26.00 0.0035 0.92 0.553209 -0.18
311 350 4rwt (D) 316 396 48.00 0.077 0.65 0.299027 0.21
408 515 5hmo (A) 808 909 22.00 0.77 0.14 0.498664 -1.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128947)

Species Accession Gene Product
Brugia malayi Bm1_54385   Legume-like lectin family protein
Candida albicans CaO19.2200   similar to S. cerevisiae YKR044W
Candida albicans CaO19.9746   similar to S. cerevisiae YKR044W
Caenorhabditis elegans CELE_T04G9.3   Protein ILE-2
Drosophila melanogaster Dmel_CG5510   CG5510 gene product from transcript CG5510-RA
Echinococcus granulosus EgrG_000903900   vesicular integral membrane protein vip36
Entamoeba histolytica EHI_162550   vesicular integral membrane protein VIP36, putative
Entamoeba histolytica EHI_104370   Legume-like lectin family protein, membrane-bound
Echinococcus multilocularis EmuJ_000903900   vesicular integral membrane protein vip36
Homo sapiens ENSG00000114988   lectin, mannose-binding 2-like
Homo sapiens ENSG00000169223   lectin, mannose-binding 2
Leishmania braziliensis LbrM.13.0490   lectin, putative
Loa Loa (eye worm) LOAG_00673   hypothetical protein
Mus musculus ENSMUSG00000021484   lectin, mannose-binding 2
Mus musculus ENSMUSG00000001143   lectin, mannose-binding 2-like
Schistosoma japonicum Sjp_0216930   ko:K10082 lectin, mannose-binding 2, putative
Schistosoma mansoni Smp_174580   vesicular integral-membrane protein vip36 (mannose-binding lectin 2)-related
Schmidtea mediterranea mk4.005415.02  
Schmidtea mediterranea mk4.010279.03  
Trypanosoma cruzi TcCLB.506177.20   lectin, putative
Trypanosoma cruzi TcCLB.506239.30   lectin, putative
Trichomonas vaginalis TVAG_371590   Submandibular gland secretory Glx-rich protein CA precursor, putative

Essentiality

TcCLB.506239.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T04G9.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506239.30 (Trypanosoma cruzi), lectin, putative
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