pI: 7.785 |
Length (AA): 640 |
MW (Da): 71221 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 13 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
64 | 510 | 1qcf (A) | 89 | 531 | 19.00 | 0 | 1 | 0.62 | 0.36 |
141 | 558 | 2etr (A) | 12 | 404 | 20.00 | 0 | 1 | 0.63 | 0.24 |
426 | 507 | 1yoj (A) | 445 | 531 | 23.00 | 0.0000065 | 0.59 | 0.45 | -1.23 |
81 | 506 | 2fo0 (A) | 92 | 524 | 19.00 | 0 | 1 | 0.575025 | 0.7 |
160 | 529 | 4lqq (A) | 303 | 707 | 25.00 | 0 | 1 | 0.395525 | 1.62 |
179 | 544 | 3war (A) | 3 | 329 | 25.00 | 0 | 1 | 0.601275 | 0.5 |
209 | 527 | 2a2a (A) | 4 | 289 | 29.00 | 0 | 1 | 0.577838 | 0.1 |
213 | 373 | 3cok (A) | 6 | 154 | 23.00 | 0 | 0.94 | 0.444663 | 0.35 |
216 | 532 | 4neu (A) | 15 | 313 | 32.00 | 0 | 1 | 0.643013 | 0.44 |
217 | 529 | 3w32 (A) | 711 | 1008 | 22.00 | 0 | 1 | 0.606462 | -0.18 |
219 | 639 | 4e3c (A) | 16 | 480 | 21.00 | 0 | 1 | 0.531213 | 1.06 |
327 | 373 | 4o1p (A) | 451 | 501 | 45.00 | 0.017 | 0.72 | 0.408138 | 0.89 |
403 | 497 | 2j0k (A) | 565 | 679 | 22.00 | 0 | 0.59 | 0.428537 | -0.69 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | metacyclic. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | epimastigote. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_142576)
Species | Accession | Gene Product |
---|---|---|
Leishmania braziliensis | LbrM.19.0070 | protein kinase |
Leishmania donovani | LdBPK_110250.1 | serine/threonine protein kinase, putative |
Leishmania infantum | LinJ.11.0250 | protein kinase, putative,serine/threonine protein kinase, putative |
Leishmania major | LmjF.11.0250 | protein kinase, putative,serine/threonine protein kinase, putative |
Leishmania mexicana | LmxM.11.0250 | protein kinase, putative,serine/threonine protein kinase, putative |
Trypanosoma brucei gambiense | Tbg972.11.7920 | protein kinase, putative,serine/threonine protein kinase, putative |
Trypanosoma brucei | Tb927.11.6990 | Calcium/calmodulin-dependent protein kinase kinase, putative |
Trypanosoma congolense | TcIL3000.11.7610 | serine/threonine protein kinase, putative |
Trypanosoma cruzi | TcCLB.511165.100 | Calcium/calmodulin-dependent protein kinase kinase, putative |
Trypanosoma cruzi | TcCLB.506775.190 | Calcium/calmodulin-dependent protein kinase kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4830 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4830 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 25.0% | 256 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 25.8% | 314 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 27.3% | 242 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 27.9% | 258 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 23.4% | 278 aa | Compounds | References |
21 literature references were collected for this gene.