Detailed view for TcCLB.507645.20

Basic information

TDR Targets ID: 42194
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0459 | Length (AA): 278 | MW (Da): 30880 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05008   Vesicle transport v-SNARE protein N-terminus
PF12352   Snare region anchored in the vesicle membrane C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0006886   intracellular protein transport  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 109 1vcs (A) 8 97 20.00 0.0000015 0.72 0.5 -0.45
154 213 1gl2 (C) 139 198 27.00 0.000095 0.05 0.56 -1.14
2 102 2qyw (A) 8 95 20.00 0 0.88 0.627509 -1.48
2 106 1vcs (A) 4 94 18.00 0 0.93 0.467898 -0.69
143 219 2nps (C) 114 190 29.00 0 0.03 0.620178 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127758)

Species Accession Gene Product
Arabidopsis thaliana AT1G26670   vesicle transport v-SNARE 12
Arabidopsis thaliana AT5G39510   vesicle transport v-SNARE 11
Candida albicans CaO19.7970   v-SNARE
Candida albicans CaO19.337   similar to v-SNARE/docking protein
Caenorhabditis elegans CELE_Y57G11C.4   Protein VTI-1
Cryptosporidium hominis Chro.30027   hypothetical protein
Cryptosporidium parvum cgd3_180   domain KOG1666, V-SNARE (intracellular trafficking, secretion, and vesicular transport)
Dictyostelium discoideum DDB_G0292974   v-SNARE family protein
Drosophila melanogaster Dmel_CG3279   VTI1 ortholog (S. cerevisiae)
Echinococcus granulosus EgrG_000477100   vesicle transport through interaction with
Entamoeba histolytica EHI_068480   hypothetical protein
Entamoeba histolytica EHI_117250   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000477100   vesicle transport through interaction with
Homo sapiens ENSG00000151532   vesicle transport through interaction with t-SNAREs 1A
Homo sapiens 10490   vesicle transport through interaction with t-SNAREs 1B
Leishmania braziliensis LbrM.23.1650   hypothetical protein, conserved
Leishmania donovani LdBPK_231800.1   hypothetical protein, conserved
Leishmania infantum LinJ.23.1800   hypothetical protein, conserved
Leishmania major LmjF.23.1750   Qb-SNARE protein, putative
Leishmania mexicana LmxM.23.1750   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02464   hypothetical protein
Mus musculus ENSMUSG00000024983   vesicle transport through interaction with t-SNAREs 1A
Mus musculus ENSMUSG00000021124   vesicle transport through interaction with t-SNAREs 1B
Neospora caninum NCLIV_067830   hypothetical protein
Neospora caninum NCLIV_017380   Vesicle transport v-SNARE domain-containing protein, related
Oryza sativa 9271687   Os01g0560350
Oryza sativa 4324687   Os01g0560200
Oryza sativa 4327678   Os01g0707300
Saccharomyces cerevisiae YMR197C   Vti1p
Schistosoma japonicum Sjp_0304890   ko:K08493 vesicle transport through interaction with t-SNAREs 1, putative
Schistosoma mansoni Smp_068480   vesicle transport V-snare protein vti1a
Schmidtea mediterranea mk4.000578.04   Putative vesicle transport V-snare protein vti1a
Trypanosoma cruzi TcCLB.509767.210   vesicle transport v-SNARE 11, putative
Trypanosoma cruzi TcCLB.507645.20   hypothetical protein, conserved
Toxoplasma gondii TGME49_242080   hypothetical protein
Toxoplasma gondii TGME49_278160   vesicle transport v-snare protein

Essentiality

TcCLB.507645.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YMR197C Saccharomyces cerevisiae inviable yeastgenome
TGME49_278160 Toxoplasma gondii Essentiality uncertain sidik
TGME49_242080 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.507645.20 (Trypanosoma cruzi), hypothetical protein, conserved
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