pI: 6.697 |
Length (AA): 357 |
MW (Da): 40198 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 355 | 2j1q (A) | 1 | 355 | 99.00 | 0 | 1 | 2.1863 | -1.51 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Ortholog group members (OG5_128330)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_37040 | ATP:guanido phosphotransferase, C-terminal catalytic domain containing protein |
Brugia malayi | Bm1_23610 | arginine kinase |
Caenorhabditis elegans | CELE_W10C8.5 | Protein W10C8.5 |
Caenorhabditis elegans | CELE_F32B5.1 | Protein F32B5.1 |
Caenorhabditis elegans | CELE_F46H5.3 | Protein F46H5.3, isoform B |
Caenorhabditis elegans | CELE_F44G3.2 | Protein F44G3.2 |
Caenorhabditis elegans | CELE_ZC434.8 | Protein ZC434.8 |
Chlamydia trachomatis | CT_675 | arginine kinase |
Drosophila melanogaster | Dmel_CG32031 | Arginine kinase |
Homo sapiens | ENSG00000104879 | creatine kinase, muscle |
Homo sapiens | ENSG00000166165 | creatine kinase, brain |
Loa Loa (eye worm) | LOAG_10519 | arginine kinase |
Loa Loa (eye worm) | LOAG_13628 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07634 | ATP:guanido phosphotransferase |
Mus musculus | ENSMUSG00000001270 | creatine kinase, brain |
Mus musculus | ENSMUSG00000030399 | creatine kinase, muscle |
Onchocerca volvulus | OVOC4467 |
|
Onchocerca volvulus | OVOC2321 |
|
Schistosoma japonicum | Sjp_0200590 | ko:K00933 creatine kinase [EC2.7.3.2], putative |
Schistosoma japonicum | Sjp_0124500 | ATP:guanidino kinase SMC74, putative |
Schistosoma mansoni | Smp_194770 | ATP:guanidino kinase (Smc74) |
Schmidtea mediterranea | mk4.004791.03 | |
Schmidtea mediterranea | mk4.018687.00 | |
Schmidtea mediterranea | mk4.002159.01 | |
Schmidtea mediterranea | mk4.008532.00 | |
Schmidtea mediterranea | mk4.001156.04 | |
Schmidtea mediterranea | mk4.000513.00 | |
Schmidtea mediterranea | mk4.007131.02 | |
Schmidtea mediterranea | mk4.007502.01 | |
Trypanosoma brucei gambiense | Tbg972.9.3300 | arginine kinase |
Trypanosoma brucei gambiense | Tbg972.9.3260 | arginine kinase |
Trypanosoma brucei gambiense | Tbg972.9.3280 | arginine kinase |
Trypanosoma brucei gambiense | Tbg972.9.3250 | arginine kinase |
Trypanosoma brucei | Tb927.9.6210 | arginine kinase |
Trypanosoma brucei | Tb927.9.6250 | arginine kinase |
Trypanosoma brucei | Tb927.9.6290 | arginine kinase |
Trypanosoma congolense | TcIL3000_0_36630 | arginine kinase |
Trypanosoma congolense | TcIL3000_9_2150 | arginine kinase |
Trypanosoma cruzi | TcCLB.507241.30 | arginine kinase |
Toxoplasma gondii | TGME49_231610 | ATP:guanido phosphotransferase, C-terminal catalytic domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.4560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.4560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.4560 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.4560 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_231610 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from enzyme inhibition (ECO:0000184) | Trypanosoma cruzi | 135961 221616 | ||
Annotator: | millerja@u.washington.edu. | Comment: | . | References: | 14693520 | |
growth (GO:0040007) | decreased (PATO:0000468) | amastigote (BTO:0000062) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 135961 221616 | |
Annotator: | millerja@u.washington.edu. | Comment: | . | References: | 14693520 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Compound | Source | Reference |
---|---|---|
Curated by TDRTargets | References | |
Curated by TDRTargets | References |
Target | Type | Source | Notes |
---|---|---|---|
TcCLB.507241.30 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Trypanosoma cruzi ( 1 ) |
13 literature references were collected for this gene.