Detailed view for TcCLB.511903.90

Basic information

TDR Targets ID: 42486
Trypanosoma cruzi, Galactose oxidase, central domain/Kelch motif containing protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.8899 | Length (AA): 392 | MW (Da): 44552 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01344   Kelch motif
PF13415   Galactose oxidase, central domain
PF13418   Galactose oxidase, central domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 328 1zgk (A) 325 596 19.00 0 1 0.83 -0.28
37 336 1zgk (A) 328 604 20.00 0 1 0.95 0.03
8 322 5a10 (A) 7 348 18.00 0 1 0.895971 0.18
9 304 5gq0 (B) 8 323 29.00 0 1 1.0129 -0.05
27 221 3ii7 (A) 374 555 32.00 0.0019 1 0.611249 0.99

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127972)

Species Accession Gene Product
Babesia bovis BBOV_II002080   kelch repeat/BTB/POZ domain containing protein
Cryptosporidium hominis Chro.30407   hypothetical protein
Cryptosporidium parvum cgd3_3600   hypothetical protein
Dictyostelium discoideum DDB_G0281209   hypothetical protein
Dictyostelium discoideum DDB_G0272386   Kelch repeat-containing protein
Dictyostelium discoideum DDB_G0282667   Kelch repeat-containing protein
Dictyostelium discoideum DDB_G0268110   Kelch repeat-containing protein
Dictyostelium discoideum DDB_G0292070   hypothetical protein
Dictyostelium discoideum DDB_G0268696   hypothetical protein
Drosophila melanogaster Dmel_CG3711   CG3711 gene product from transcript CG3711-RE
Giardia lamblia GL50803_15054   Kelch repeat-containing protein
Homo sapiens ENSG00000099949   leucine-zipper-like transcription regulator 1
Leishmania braziliensis LbrM.24.2170   hypothetical protein, conserved
Leishmania donovani LdBPK_242180.1   Kelch motif/Galactose oxidase, central domain containing protein, putative
Leishmania infantum LinJ.24.2180   hypothetical protein, conserved
Leishmania major LmjF.24.2090   hypothetical protein, conserved
Leishmania mexicana LmxM.24.2090   hypothetical protein, conserved
Mus musculus ENSMUSG00000022761   leucine-zipper-like transcriptional regulator, 1
Neospora caninum NCLIV_014230   hypothetical protein
Plasmodium berghei PBANKA_1323800   kelch domain-containing protein, putative
Plasmodium knowlesi PKNH_1221600   kelch domain-containing protein, putative
Plasmodium vivax PVX_117450   kelch domain-containing protein
Plasmodium yoelii PY01757   Drosophila melanogaster LP01394p
Plasmodium yoelii PY01915   hypothetical protein
Trypanosoma brucei gambiense Tbg972.8.6190   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.6140   Galactose oxidase, central domain/Kelch motif containing protein, putative
Trypanosoma congolense TcIL3000_8_5980   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511071.10   Galactose oxidase, central domain/Kelch motif containing protein, putative
Trypanosoma cruzi TcCLB.511903.90   Galactose oxidase, central domain/Kelch motif containing protein, putative
Toxoplasma gondii TGME49_286240   kelch repeat protein, putative
Toxoplasma gondii TGME49_298600   leucine zipper-like transcriptional regulator
Theileria parva TP04_0343   hypothetical protein
Trichomonas vaginalis TVAG_270740   kelch repeat protein, putative
Trichomonas vaginalis TVAG_145810   kelch repeat protein, putative
Trichomonas vaginalis TVAG_135930   kelch repeat protein, putative
Trichomonas vaginalis TVAG_027650   kelch repeat protein, putative
Trichomonas vaginalis TVAG_492570   kelch repeat protein, putative
Trichomonas vaginalis TVAG_025730   guanine nucleotide exchange factor, putative
Trichomonas vaginalis TVAG_127010   kelch repeat protein, putative
Trichomonas vaginalis TVAG_493050   kelch repeat domain, putative
Trichomonas vaginalis TVAG_097900   host cell factor C1, putative
Trichomonas vaginalis TVAG_007480   kelch repeat protein, putative
Trichomonas vaginalis TVAG_061200   kelch domain containing 3/peas, putative
Trichomonas vaginalis TVAG_388840   kelch repeat protein, putative
Trichomonas vaginalis TVAG_180560   kelch repeat protein, putative
Trichomonas vaginalis TVAG_421420   kelch repeat domain, putative
Trichomonas vaginalis TVAG_099410   tea3, putative
Trichomonas vaginalis TVAG_163700   kelch repeat domain, putative
Trichomonas vaginalis TVAG_451250   kelch repeat protein, putative
Trichomonas vaginalis TVAG_218270   kelch repeat domain, putative
Trichomonas vaginalis TVAG_222850   kelch repeat protein, putative
Trichomonas vaginalis TVAG_106690   kelch domain containing 3/peas, putative
Trichomonas vaginalis TVAG_194180   kelch repeat protein, putative
Trichomonas vaginalis TVAG_275350   kelch repeat protein, putative
Trichomonas vaginalis TVAG_341280   kelch repeat domain, putative
Trichomonas vaginalis TVAG_404230   kelch repeat protein, putative
Trichomonas vaginalis TVAG_073700   Rho/RAC guanine nucleotide exchange factor, putative
Trichomonas vaginalis TVAG_462380   kelch repeat protein, putative
Trichomonas vaginalis TVAG_411780   kelch domain containing protein, putative
Trichomonas vaginalis TVAG_071930   kelch repeat domain, putative
Trichomonas vaginalis TVAG_033030   kelch repeat protein, putative
Trichomonas vaginalis TVAG_070490   kelch repeat domain, putative

Essentiality

TcCLB.511903.90 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6140 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.6140 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.6140 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.6140 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1323800 Plasmodium berghei Dispensable plasmo
TGME49_298600 Toxoplasma gondii Probably non-essential sidik
TGME49_286240 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.511903.90 (Trypanosoma cruzi), Galactose oxidase, central domain/Kelch motif containing protein, putative
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