Detailed view for PF3D7_0522500

Basic information

TDR Targets ID: 4256
Plasmodium falciparum, 50S ribosomal protein L17, apicoplast, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 11.3226 | Length (AA): 166 | MW (Da): 19695 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01196   Ribosomal protein L17

Gene Ontology

Mouse over links to read term descriptions.
GO:0005762   mitochondrial large ribosomal subunit  
GO:0005622   intracellular  
GO:0005840   ribosome  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 138 2aw4 (N) 1 116 38.00 0 1 1.27 0.41
33 138 1gd8 (A) 15 117 40.00 0 1 1.4 -1.72
49 165 5dm6 (K) 3 115 43.00 0 1 1.27572 -0.79
54 166 4wfa (K) 4 122 45.00 0 1 1.18572 -0.36
60 166 1gd8 (A) 14 117 39.00 0 1 1.22048 -1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, early schizont, Ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile late schizont, late trophozoite. PlasmoDB
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_127423)

Species Accession Gene Product
Arabidopsis thaliana AT3G54210   50S ribosomal protein L17
Arabidopsis thaliana AT5G64650   large subunit ribosomal protein L17
Arabidopsis thaliana AT5G09770   ribosomal protein L17 family protein
Babesia bovis BBOV_III003930   50S ribosomal subunit protein L17, putative
Brugia malayi Bm1_42730   hypothetical protein
Candida albicans CaO19.6129   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL8 (YJL063C) large subunit protein L8 (E. coli L17)
Candida albicans CaO19.13548   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL8 (YJL063C) large subunit protein L8 (E. coli L17)
Caenorhabditis elegans CELE_Y54E10A.7   Protein MRPL-17
Chlamydia trachomatis CT_506   50S ribosomal protein L17
Dictyostelium discoideum DDB_G0281435   ribosomal protein L17, mitochondrial
Drosophila melanogaster Dmel_CG13880   mitochondrial ribosomal protein L17
Escherichia coli b3294   50S ribosomal subunit protein L17
Homo sapiens ENSG00000158042   mitochondrial ribosomal protein L17
Loa Loa (eye worm) LOAG_03663   hypothetical protein
Mycobacterium leprae ML1956c   PROBABLE 50S RIBOSOMAL PROTEIN L17 RPLQ
Mus musculus 27397   mitochondrial ribosomal protein L17
Mycobacterium tuberculosis Rv3456c   50S ribosomal protein L17 RplQ
Mycobacterium ulcerans MUL_0849   50S ribosomal protein L17
Neospora caninum NCLIV_062370   At5g09770, related
Oryza sativa 4327382   Os01g0839300
Oryza sativa 4334555   Os03g0815400
Plasmodium berghei PBANKA_1237200   50S ribosomal protein L17, apicoplast, putative
Plasmodium falciparum PF3D7_0522500   50S ribosomal protein L17, apicoplast, putative
Plasmodium knowlesi PKNH_1010400   50S ribosomal protein L17, apicoplast, putative
Plasmodium yoelii PY00041   ribosomal protein L17, putative
Saccharomyces cerevisiae YJL063C   mitochondrial 54S ribosomal protein YmL8
Schistosoma japonicum Sjp_0217230   IPR000456,Ribosomal protein L17,domain-containing
Schistosoma mansoni Smp_174980   mitochondrial ribosomal protein L17
Schmidtea mediterranea mk4.020572.00   39S ribosomal protein L17, mitochondrial
Toxoplasma gondii TGME49_217590   50S ribosomal protein L17, putative
Treponema pallidum TP0213   50S ribosomal protein L17
Theileria parva TP03_0011   40S ribosomal protein L17, putative
Wolbachia endosymbiont of Brugia malayi Wbm0317   50S ribosomal protein L17

Essentiality

PF3D7_0522500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3294 Escherichia coli essential goodall
CELE_Y54E10A.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y54E10A.7 Caenorhabditis elegans larval arrest wormbase
CELE_Y54E10A.7 Caenorhabditis elegans slow growth wormbase
PBANKA_1237200 Plasmodium berghei Essential plasmo
TGME49_217590 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0522500 (Plasmodium falciparum), 50S ribosomal protein L17, apicoplast, putative
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